公开(公告)号：US11813588B2

公开(公告)日：2023-11-14

申请号：US17146447

申请日：2021-01-11

Applicant: DIONEX CORPORATION

Inventor： Xiaodong Liu ,  Xiao Cui ,  Xuefei Sun

IPC: B01D15/20 ,  B01D15/32 ,  B01J20/289 ,  B01J20/32 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/238 ,  B01J20/287 ,  B01J20/30 ,  C07D493/04 ,  C07H1/06 ,  C07H15/224 ,  C08G77/392

CPC classification number: B01J20/287 ,  B01D15/20 ,  B01D15/325 ,  B01J20/289 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/328 ,  B01J20/3217 ,  B01J20/3272 ,  C07D493/04 ,  C07H1/06 ,  C07H15/224 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/238 ,  C08G77/392 ,  B01J2220/44 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58

Abstract: A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.

公开(公告)号：US20230272344A1

公开(公告)日：2023-08-31

申请号：US18099233

申请日：2023-01-19

Applicant: BIOLEGEND, INC.

Inventor： DHANESH GOHEL ,  HONG ZHANG ,  JOHN RANSOM

IPC: C12N5/0789 ,  G01N33/543 ,  C12N15/10 ,  G01N33/552 ,  B01J20/06 ,  B01J20/10 ,  B01J20/24 ,  B01J20/28 ,  C07K16/28 ,  C12N5/0783 ,  A61K35/28 ,  B01J20/32 ,  B03C1/015 ,  B03C1/28

CPC classification number: C12N5/0647 ,  A61K35/28 ,  B01J20/06 ,  B01J20/10 ,  B01J20/103 ,  B01J20/24 ,  B01J20/28007 ,  B01J20/28009 ,  B01J20/28021 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3236 ,  B01J20/328 ,  B01J20/3289 ,  B01J20/3293 ,  B03C1/015 ,  B03C1/28 ,  C07K16/2812 ,  C12N5/0637 ,  C12N15/1013 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/54346 ,  G01N33/552 ,  B03C2201/18 ,  B03C2201/26

Abstract: The methods of the invention employ targeted magnetic particles, preferably targeted nanomagnetic particles, and targeted buoyant particles such as buoyant microparticles and microbubbles. Among the benefits of the invention is the ability to combine targeted magnetic particles with differentially targeted buoyant particles to achieve separation of two or more specifically cell targeted populations during the same work flow.

公开(公告)号：US20190201812A1

公开(公告)日：2019-07-04

申请号：US16311750

申请日：2017-06-20

Applicant: CLEMSON UNIVERSITY

Inventor： R. Kenneth MARCUS ,  LIUWEI JIANG

IPC: B01D15/20 ,  B01J20/26 ,  B01J20/286 ,  B01J20/32 ,  B01J20/30 ,  B01J20/28

CPC classification number: B01D15/20 ,  B01D15/22 ,  B01D15/305 ,  B01D15/361 ,  B01D15/3804 ,  B01D63/02 ,  B01D67/0093 ,  B01D69/082 ,  B01D71/56 ,  B01D2323/38 ,  B01J20/264 ,  B01J20/28023 ,  B01J20/286 ,  B01J20/3078 ,  B01J20/3212 ,  B01J20/3278 ,  B01J20/328 ,  B01J39/26 ,  B01J41/20 ,  B01J47/127 ,  B01J2220/58 ,  G01N33/68

Abstract: Chromatography devices and methods for forming and using the devices are described. The devices include a polyimide-based support phase and a polymer grafted to a surface of the polyimide-based support phase. A microwave-assisted graft polymerization protocol is described to form the polymer at the surface of the support phase. Devices can be utilized in high-efficiency separation of macromolecules such as proteins.

公开(公告)号：US20180243724A1

公开(公告)日：2018-08-30

申请号：US15758012

申请日：2016-07-07

Applicant: Sartorius Stedim Biotech GmbH

Inventor： Louis Villain ,  Florian Taft ,  Jan Schwellenbach

IPC: B01J20/289 ,  C07K1/18 ,  B01J20/32 ,  C12N9/36 ,  B01D15/20

CPC classification number: B01J20/289 ,  B01D15/20 ,  B01D15/362 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3278 ,  B01J20/328 ,  B01J20/3293 ,  C07K1/16 ,  C07K1/18 ,  C12N9/2462

Abstract: The present invention relates to an adsorption medium, especially a chromatography medium, to a method for the production thereof, and to the use of the adsorption medium according to the invention or of an adsorption medium produced according to the invention for the purification of biomolecules.

公开(公告)号：US20180008959A1

公开(公告)日：2018-01-11

申请号：US15543809

申请日：2016-01-12

Applicant: DIONEX CORPORATION

Inventor： Xiaodong LIU ,  Xiao CUI ,  Xuefei SUN

IPC: B01J20/287 ,  B01D15/20 ,  C07H15/234 ,  C07H15/232 ,  C07H15/23 ,  B01J20/32 ,  C07H1/06 ,  C07D493/04 ,  C07H15/238 ,  B01D15/32 ,  B01J20/289 ,  B01J20/30 ,  C08G77/392 ,  C07H15/224

CPC classification number: B01J20/287 ,  B01D15/20 ,  B01D15/325 ,  B01J20/289 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3272 ,  B01J20/328 ,  B01J2220/44 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58 ,  C07D493/04 ,  C07H1/06 ,  C07H15/224 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/238 ,  C08G77/392

Abstract: A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.

公开(公告)号：US09527059B2

公开(公告)日：2016-12-27

申请号：US14660153

申请日：2015-03-17

Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES

Inventor： Abuzar Kabir ,  Kenneth G. Furton

IPC: B01L3/00 ,  B01L99/00 ,  B01J20/32 ,  B01J20/286 ,  G01N1/40 ,  G01N1/02

CPC classification number: B01J20/3212 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3276 ,  B01J20/328 ,  B01J20/3285 ,  B01J2220/64 ,  G01N1/405 ,  G01N2001/027

Abstract: A field kit for collecting analytical samples has one or more dynamic fabric phase sorptive extraction (DFPSE) devices and/or fabric phase sorptive extraction (FPSE) devices and a plurality of containers for storing and transporting the DFPSEs and/or FPSEs that were used for sampling. The field kit has media for documenting information concerning the site, quantity, date, and/or other pertinent information concerning the sampling. Samples can be maintained within the kit for any required period of storage. Sampling can be done once or a plurality of times, such that an initial analysis can be carried out and analysis can be repeated using a portion of a FPSE or with a redundant FPSE that has been stored. The DFPSE device is a sampling device including a plurality of FPSEs, such that a number of different types of analytes can be sampled in different layers of the DFPSE. At least one external surface layer of the DFPSE is a barrier FPSE that restricts solids from underlying layers.

Abstract translation: 用于收集分析样品的现场试剂盒具有一个或多个动态织物相吸附萃取（DFPSE）装置和/或织物相吸附提取（FPSE）装置和用于储存和运输用于DFPSE和/或FPSE的DFPSE和/或FPSE的多个容器 采样。 现场工具包有媒体记录有关采样的站点，数量，日期和/或其他相关信息的信息。 样品可以保存在试剂盒中以保持任何所需的储存期。 可以进行一次或多次采样，使得可以执行初始分析并且可以使用FPSE的一部分或已经存储的冗余FPSE来重复分析。 DFPSE设备是包括多个FPSE的采样设备，使得可以在DFPSE的不同层中对多个不同类型的分析物进行采样。 DFPSE的至少一个外表面层是限制来自下层的固体的屏障FPSE。

公开(公告)号：US09018267B2

公开(公告)日：2015-04-28

申请号：US14254247

申请日：2014-04-16

Applicant: 3M Innovative Properties Company

Inventor： Simon K. Shannon ,  Catherine A. Bothof ,  Babu N. Gaddam ,  Jerald K. Rasmussen ,  Richard B. Ross

IPC: B01D15/08 ,  B01J39/18 ,  C08F20/56 ,  C08F271/02 ,  B01J20/286 ,  B01J20/32 ,  B01J39/16 ,  B01J41/12 ,  B01J20/26 ,  B01J20/287 ,  C07K1/22 ,  B01J39/20 ,  B01J41/14 ,  B01D15/38

CPC classification number: C07K17/08 ,  B01D15/08 ,  B01D15/3804 ,  B01D15/3809 ,  B01J20/264 ,  B01J20/286 ,  B01J20/287 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3255 ,  B01J20/3276 ,  B01J20/3278 ,  B01J20/328 ,  B01J39/17 ,  B01J39/18 ,  B01J39/20 ,  B01J41/12 ,  B01J41/14 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/62 ,  C07K1/22 ,  C08F271/02

Abstract: Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.

Abstract translation: 描述了含有从固体支持物延伸的接枝链的固体支持物的制品，制造这些制品的方法以及制品的各种用途。 更具体地，接枝链具有可与目标化合物反应或与其相互作用的官能团。 或者，接枝链上的官能团可以与改性剂反应，以提供可与目标化合物反应或与目标化合物相互作用的另一个基团。 接枝的链通过开环的吖内酯基团连接到固体支持物上。 该制品可用于纯化目标化合物或将目标化合物与样品中的其它分子分离。

公开(公告)号：US20150060342A1

公开(公告)日：2015-03-05

申请号：US14535461

申请日：2014-11-07

Applicant: EMD Millipore Corporation

Inventor： Anthony J. DiLeo ,  Justin McCue ,  Wilson Moya ,  Igor Quinones-Garcia ,  Neil P. Soice ,  Volkmar Thom ,  Sarah Yuan

IPC: B01D15/20 ,  B01D15/26 ,  B01D15/36

CPC classification number: B01D15/20 ,  B01D15/265 ,  B01D15/361 ,  B01J20/26 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/28042 ,  B01J20/28078 ,  B01J20/28097 ,  B01J20/286 ,  B01J20/3064 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/328 ,  B01J20/3282 ,  B01J20/3289 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/62

Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.

Abstract translation: 能够吸附过滤具有多孔自支撑基底和一种或多种多孔吸附聚合物涂层的多孔基底，其包含基底孔隙体积的约1至约80％。 所得到的底物具有良好的对流和扩散流量和容量。 底物可以是交联的，具有一个或多个捕获化学物质连接到其上，并且可用作用于选择性过滤所需物质（包括生物分子例如蛋白质和DNA片段）的色谱介质。

公开(公告)号：US08906132B2

公开(公告)日：2014-12-09

申请号：US13264216

申请日：2009-07-27

Applicant: Yeoung-Sang Yun ,  Sung Wook Won ,  Sun Beom Choi ,  Sok Kim ,  Juan Mao ,  In-Seob Kwak ,  Jiyeong Park ,  Myung Hee Song ,  Min A Bae ,  Shi Yn Lee ,  Sneha Krishnamurthy ,  Thi Phuong Thuy Pham ,  Chul Woong Cho

Inventor： Yeoung-Sang Yun ,  Sung Wook Won ,  Sun Beom Choi ,  Sok Kim ,  Juan Mao ,  In-Seob Kwak ,  Jiyeong Park ,  Myung Hee Song ,  Min A Bae ,  Shi Yn Lee ,  Sneha Krishnamurthy ,  Thi Phuong Thuy Pham ,  Chul Woong Cho

IPC: C22B11/00 ,  C08G73/10 ,  B82Y30/00 ,  B01J20/32 ,  C22B3/00 ,  B01J20/26 ,  C02F1/28 ,  C22B3/24 ,  C02F101/20 ,  C02F1/42

CPC classification number: B01J20/26 ,  B01J20/265 ,  B01J20/267 ,  B01J20/3206 ,  B01J20/3242 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/328 ,  B01J20/3282 ,  B01J45/00 ,  B01J2220/4868 ,  C02F1/286 ,  C02F1/288 ,  C02F2001/422 ,  C02F2101/20 ,  C22B3/24 ,  C22B11/042 ,  C22B11/044 ,  C22B11/046 ,  Y02P10/214 ,  Y02P10/234 ,  Y10S977/742

Abstract: The present invention relates to a surface-modified biomass which is crosslinked with an amine group-containing cationic polymer on the surface of a cell biomass, its preparation method, and a method for recovering valuable metals using the same. The surface-modified biomass of the present invention has an advantage of improving adsorption of and affinity with anionic pollutants as a result of further introducing a cationic functional group by crosslinking of the amine group-containing cationic polymer on the surface of the biomass. In addition, the method for recovering valuable metals with the present invention is environment-friendly, economical, and harmless to the human body.

Abstract translation: 本发明涉及在细胞生物质的表面与含胺基的阳离子聚合物交联的表面改性生物质，其制备方法和使用该生物质回收有价金属的方法。 本发明的表面改性生物质具有通过在生物质表面交联含胺基的阳离子聚合物进一步引入阳离子官能团，具有改善对阴离子污染物的吸附和亲和性的优点。 此外，本发明的回收贵金属的方法对人体是环境友好，经济，无害的。

公开(公告)号：US08679346B2

公开(公告)日：2014-03-25

申请号：US13199249

申请日：2011-08-24

Applicant: Yasuhiro Kagamihara

Inventor： Yasuhiro Kagamihara

IPC: B01D15/20 ,  B01D15/38 ,  B01D15/00 ,  G01N30/30

CPC classification number: B01J20/29 ,  B01D15/3833 ,  B01J20/286 ,  B01J20/3272 ,  B01J20/328 ,  G01N30/56 ,  G01N2030/027 ,  G01N2030/565

Abstract: An enantiomeric isomer separating agent includes a polysaccharide derivative supported by particles of a support by chemical bonding and has a concentration of eluted component (in terms of mass proportion), as determined through a liquid passing test of 20 ppm or lower.

Abstract translation: 对映异构体异构体分离剂包括通过化学键合由载体的颗粒负载的多糖衍生物，并且通过20ppm以下的液体通过试验确定了洗脱成分的浓度（以质量比计）。