公开(公告)号：US08956545B2

公开(公告)日：2015-02-17

申请号：US13809703

申请日：2011-07-08

Applicant: Hyung Il Jung ,  Kwang Lee ,  Sin Kil Cho ,  Young Dook Byeon

Inventor： Hyung Il Jung ,  Kwang Lee ,  Sin Kil Cho ,  Young Dook Byeon

IPC: C25F3/00 ,  A61M5/00 ,  A61M37/00 ,  A61B5/1486 ,  A61F9/007 ,  B29D23/00 ,  A61K9/00 ,  B81C1/00 ,  B29C41/08 ,  B29C41/36 ,  B29C41/38 ,  G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  B29L31/00

CPC classification number: A61M5/00 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/685 ,  A61F9/00781 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C41/08 ,  B29C41/36 ,  B29C41/38 ,  B29D23/00 ,  B29L2031/7544 ,  B81B2201/055 ,  B81C1/00111 ,  G01N33/49

Abstract: The present invention relates to a method for fabricating a hollow microneedle having a variable appearance. The method makes it possible to vary the length of the microneedle, the outer and inner diameters of the upper and lower parts thereof, the aspect ratio, the sharpness, and the structural bending rate thereof, in accordance with the purposes of the same. Accordingly, the appearance of the hollow microneedles according to the present invention can be varied with flexibility according to various purposes, such as the transferring of medication and the taking of a blood sample, and to various factors, such as the target part for the medication transfer, the depth of the medication transfer, and the amount and viscosity of the medication. Thus, the microneedle can be used as a multi-purpose device for transferring medication.

Abstract translation: 本发明涉及具有可变外观的中空微针的制造方法。 该方法根据其目的，可以改变微针的长度，其上部和下部的外径和内径，纵横比，锐度和结构弯曲率。 因此，根据本发明的中空微针的外观可以根据各种目的的灵活性而变化，例如药物的转移和血液样品的摄取，以及各种因素，例如药物的目标部分 转移，药物转移的深度以及药物的量和粘度。 因此，微针可以用作用于转移药物的多用途装置。

公开(公告)号：US08771781B2

公开(公告)日：2014-07-08

申请号：US12599394

申请日：2007-10-18

Applicant: Seiji Tokumoto ,  Toshiyuki Matsudo ,  Tetsuji Kuwahara

Inventor： Seiji Tokumoto ,  Toshiyuki Matsudo ,  Tetsuji Kuwahara

IPC: A61M3/00 ,  B05D1/18

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C1/00206

Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).

Abstract translation: 本发明提供了一种涂布微针的方法，通过该方法，安装在微针装置上的微针以可批量生产的方式精确且容易地被涂布。 在该方法中，将具有多个微针（21）的微针装置（22）安装在工作台（23）上，同时具有多个孔（24）的掩模板（25）固定到框架构件（26） ），并且使用刮刀（28）在掩模板（25）上沿箭头A的方向将涂布溶液（27）用涂布溶液填充孔（24）。 在用涂布溶液（27）填充孔（24）之前或之后，将微针（21）插入孔（24）中以涂覆微针（21）。

公开(公告)号：US20120132613A1

公开(公告)日：2012-05-31

申请号：US13118171

申请日：2011-05-27

Applicant: Rajmohan Bhandari ,  Sandeep Negi ,  Florian Solzbacher ,  Richard A. Normann

Inventor： Rajmohan Bhandari ,  Sandeep Negi ,  Florian Solzbacher ,  Richard A. Normann

IPC: B44C1/22 ,  H01B13/00

CPC classification number: B81C1/00111 ,  A61M2037/0053 ,  A61N1/0551 ,  B81B2201/055 ,  Y10T428/24479

Abstract: Methods for wafer-scale fabrication of needle arrays can include mechanically modifying a wafer to produce a plurality of vertically-extending columns. The columns are etched to round and reshape the columns into substantially uniformly shaped needles. Needle arrays having needle width non-uniformity of less than about 3% and length non-uniformity of less than about 2% can be produced.

Abstract translation: 用于晶圆尺寸制造针阵列的方法可以包括机械地改变晶片以产生多个垂直延伸的柱。 将柱蚀刻成圆形并将柱重新形成基本均匀成形的针。 可以制造具有小于约3％的针宽不均匀性和小于约2％的长度不均匀性的针阵列。

公开(公告)号：US20110223542A1

公开(公告)日：2011-09-15

申请号：US12866717

申请日：2009-02-05

Applicant: Mark Anthony Fernance Kendall

Inventor： Mark Anthony Fernance Kendall

IPC: G03F7/20

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61K9/0097 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  H01J37/32009 ,  H01J37/3244 ,  H01J2237/334

Abstract: A method of producing projections on a patch including providing a mask on a substrate and etching the substrate using an etchant and a passivant to thereby control the etching process and form the projections, wherein the passivant does not include oxygen.

Abstract translation: 一种在贴片上制造突起的方法，包括在基片上提供掩模，并使用蚀刻剂和钝化剂蚀刻基底，从而控制蚀刻工艺并形成突起，其中钝化剂不包括氧。

公开(公告)号：US20110193270A1

公开(公告)日：2011-08-11

申请号：US13025861

申请日：2011-02-11

Applicant: Yung-Chieh Tan

Inventor： Yung-Chieh Tan

IPC: B29C59/00 ,  B29B7/72

CPC classification number: B29C44/385 ,  B01D39/00 ,  B26F1/26 ,  B26F1/28 ,  B26F3/004 ,  B29C31/042 ,  B29C33/0033 ,  B29C39/24 ,  B29C39/26 ,  B29C39/42 ,  B29C41/12 ,  B29C41/36 ,  B29C41/38 ,  B29C2793/0045 ,  B29L2031/14 ,  B29L2031/737 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00373 ,  B82Y30/00

Abstract: Methods of and devices for making pores, nozzles, and slits are described. In some embodiments, the methods create pattern in the molded substrate by controlling the location and direction of a controlled flow stream through molding plates. The molding plate contains a predefined pattern that is able to be used to create the desired pattern in the molding plate.

Abstract translation: 描述了制造孔，喷嘴和狭缝的方法和装置。 在一些实施例中，该方法通过控制通过模制板的受控流动流的位置和方向在模制基底中产生图案。 成型板包含能够用于在模制板中产生所需图案的预定图案。

公开(公告)号：US07906273B2

公开(公告)日：2011-03-15

申请号：US11798884

申请日：2007-05-17

Applicant: Chien-Chung Fu

Inventor： Chien-Chung Fu

IPC: G03F7/00

CPC classification number: B29C35/0894 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C2035/0827 ,  B81B2201/055 ,  B81C1/00111

Abstract: A method of manufacturing a hollow micro-needle structure includes the steps of: disposing a first mask layer and a second mask layer respectively aside a first substrate and aside a rear surface of the first substrate, wherein the first substrate is transparent to predetermined light; forming a photoresist layer on the front surface of the first substrate and the first mask layer; providing the predetermined light to illuminate the first substrate in a direction from the rear surface to the front surface so as to expose the photoresist layer to form an exposed portion and an unexposed portion; and removing the unexposed portion to form the micro-needle structure, which is formed by the exposed portion. The micro-needle structure has an inclined sidewall and a through hole surrounded by the inclined sidewall.

Abstract translation: 一种中空微针结构体的制造方法，其特征在于，包括：将第一掩模层和第二掩模层分别配置在第一基板的外侧，将第一基板的背面放置在第一基板的背面， 在所述第一基板和所述第一掩模层的前表面上形成光致抗蚀剂层; 提供所述预定光以在从所述后表面到所述前表面的方向上照亮所述第一基板，以暴露所述光致抗蚀剂层以形成暴露部分和未曝光部分; 并且去除未曝光部分以形成由暴露部分形成的微针结构。 微针结构具有倾斜侧壁和由倾斜侧壁包围的通孔。

公开(公告)号：US20100193997A1

公开(公告)日：2010-08-05

申请号：US11916468

申请日：2006-06-08

Applicant: Franklyn L. Frederickson ,  Dennis E. Ferguson

Inventor： Franklyn L. Frederickson ,  Dennis E. Ferguson

IPC: B29C33/42 ,  B29C59/02 ,  B29C35/08

CPC classification number: B81C99/009 ,  B29C33/00 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111

Abstract: The present invention is directed to a method of forming a mold for use in making molded articles having a plurality of microprojections. Additionally, the present invention provides a method of forming a molded article having a plurality of microprojections. In one aspect, a mold workpiece is provided, a tool having a tip with a shape corresponding to the microprojection, wherein the hardness of the tool is greater than that of the mold workpiece, is pressed into the mold workpiece and removed, thereby creating a mold with a microprojection cavity suitable for use in making the molded article.

Abstract translation: 本发明涉及一种形成用于制造具有多个微喷射体的模制品的模具的方法。 另外，本发明提供了形成具有多个微喷射体的成型品的方法。 一方面，提供了模具工件，具有具有对应于微喷射体的形状的尖端的工具，其中刀具的硬度大于模具工件的硬度，被压入模具工件并移除，从而形成 具有适合用于制造模制品的微型喷射腔的模具。

公开(公告)号：US20100185162A1

公开(公告)日：2010-07-22

申请号：US12749001

申请日：2010-03-29

Applicant: Kazuhiko SHIOMITSU ,  Hiroshi Sugimura ,  Toshiaki Kurosu ,  Gaku Suzuki ,  Takao Tomono

Inventor： Kazuhiko SHIOMITSU ,  Hiroshi Sugimura ,  Toshiaki Kurosu ,  Gaku Suzuki ,  Takao Tomono

IPC: A61M5/00 ,  C23F1/00 ,  B28B11/08

CPC classification number: B44C1/227 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/42 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/0198

Abstract: The invention discloses a method of manufacturing a microneedle including the steps of forming an island etching mask having thickness distribution on a substrate, and processing the substrate into a needle by taking advantage of a difference in etching rates between the etching mask and the substrate. The invention enables to readily control a point angle and height of the manufactured needle.

Abstract translation: 本发明公开了一种制造微针的方法，包括以下步骤：在衬底上形成具有厚度分布的岛蚀刻掩模，并通过利用蚀刻掩模和衬底之间的蚀刻速率差来将衬底处理成针。 本发明能够容易地控制所制造的针的点角度和高度。

公开(公告)号：US20090239072A1

公开(公告)日：2009-09-24

申请号：US12313935

申请日：2008-11-26

Applicant: Yang Wei ,  Liang Liu ,  Shou-Shan Fan

Inventor： Yang Wei ,  Liang Liu ,  Shou-Shan Fan

IPC: D01F9/12 ,  H05B6/00

CPC classification number: C01B32/168 ,  B81B2201/055 ,  B81C1/00111 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/162 ,  C01B2202/02 ,  C01B2202/04 ,  C01B2202/06 ,  C01B2202/08 ,  C01B2202/34 ,  C01B2202/36 ,  Y10T428/2982

Abstract: A carbon nanotube needle comprising: an end portion and a broken end portion, the broken end portion comprising a single carbon nanotube tip. A method for manufacturing a carbon nanotube needle, the method comprising the steps of: (a) providing a carbon nanotube film comprising of a plurality of commonly aligned carbon nanotubes, a first electrode, and a second electrode; (b) fixing the carbon nanotube film to the first electrode and the second electrode, the carbon nanotube film extending from the first electrode to the second electrode; (c) treating the carbon nanotube film with an organic solvent to form at least one carbon nanotube string; and (d) applying a voltage to the carbon nanotube string until the carbon nanotube string snaps.

Abstract translation: 一种碳纳米管针，包括：端部和断端部，所述断端部包括单个碳纳米管尖端。 一种制造碳纳米管针的方法，所述方法包括以下步骤：（a）提供由多个共同排列的碳纳米管组成的碳纳米管膜，第一电极和第二电极; （b）将碳纳米管膜固定到第一电极和第二电极，碳纳​​米管膜从第一电极延伸到第二电极; （c）用有机溶剂处理碳纳米管膜以形成至少一个碳纳米管串; 和（d）向碳纳米管串施加电压，直到碳纳米管柱咬合为止。

公开(公告)号：US20090220710A1

公开(公告)日：2009-09-03

申请号：US12397197

申请日：2009-03-03

Applicant: Douglas Ray Sparks ,  Nader Najafi

Inventor： Douglas Ray Sparks ,  Nader Najafi

IPC: B32B1/08 ,  H01L21/50

CPC classification number: B81B1/002 ,  B01L3/5027 ,  B81B2201/0242 ,  B81B2201/055 ,  B81B2203/0323 ,  B81B2203/0338 ,  B81C1/00 ,  B81C1/00119 ,  B81C1/0019 ,  B81C1/00357 ,  B81C1/00468 ,  G01F1/84 ,  G01F1/8404 ,  G01F1/8409 ,  G01F1/844 ,  G01F1/8445 ,  Y10T428/13 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A process for producing a micromachined tube (microtube) suitable for microfluidic devices. The process entails isotropically etching a surface of a first substrate to define therein a channel having an arcuate cross-sectional profile, and forming a substrate structure by bonding the first substrate to a second substrate so that the second substrate overlies and encloses the channel to define a passage having a cross-sectional profile of which at least half is arcuate. The substrate structure can optionally then be thinned to define a microtube and walls thereof that surround the passage.

Abstract translation: 一种适用于微流体装置的微加工管（微管）的制造方法。 该方法需要各向同性蚀刻第一衬底的表面以在其中限定具有弓形横截面轮廓的通道，并且通过将第一衬底粘合到第二衬底来形成衬底结构，使得第二衬底覆盖并封闭沟道以限定 具有至少一半弧形的截面轮廓的通道。 衬底结构可任选地被减薄以限定围绕通道的微管及其壁。