公开(公告)号：US20160282273A1

公开(公告)日：2016-09-29

申请号：US15080256

申请日：2016-03-24

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Xiaohong Bi ,  Zhiyong Wang

IPC: G01N21/65 ,  A61B5/00 ,  G02B6/35

CPC classification number: G02B6/3504 ,  A61B5/0075 ,  A61B5/4504 ,  A61B2562/0233 ,  G01N21/49 ,  G01N21/65 ,  G01N2201/0846 ,  G02B6/00 ,  G02B6/3578

Abstract: Apparatus and method for optical spectroscopy and/or imaging with a variable fiber offset. An optical probe includes one or more first optical fibers, one or more second optical fibers, and one or more actuators. The first optical fibers are to deliver light to an object. The second optical fibers are to collect light emitted from the object. The actuators are configured to change a distance between the first optical fibers and the second optical fiber while the object is being illuminated by light emitted from the first optical fibers.

Abstract translation: 用于具有可变光纤偏移的光学光谱和/或成像的装置和方法。 光学探头包括一个或多个第一光纤，一个或多个第二光纤以及一个或多个致动器。 第一光纤是将光传送到物体上。 第二光纤是收集从物体发射的光。 致动器构造成在物体被从第一光纤发射的光照射时改变第一光纤和第二光纤之间的距离。

公开(公告)号：US20160113507A1

公开(公告)日：2016-04-28

申请号：US14919565

申请日：2015-10-21

Applicant: Parsin Haji Reza ,  Roger Zemp

Inventor： Parsin Haji Reza ,  Roger Zemp

IPC: A61B5/00 ,  G01N21/17

CPC classification number: A61B5/0095 ,  G01N21/1702 ,  G01N21/1717 ,  G01N2021/1706 ,  G01N2021/1725 ,  G01N2201/06113 ,  G01N2201/08 ,  G01N2201/0846

Abstract: A photoacoustic remote sensing system (PARS) for imaging a subsurface structure in a sample has an excitation beam configured to generate ultrasonic signals in the sample at an excitation location; an interrogation beam incident on the sample at the excitation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic signals; an optical system that focuses at least one of the excitation beam and the interrogation beam with a focal point that is below the surface of the sample; and a detector that detects the returning portion of the interrogation beam.

Abstract translation: 用于对样品中的地下结构进行成像的光声遥感系统（PARS）具有被配置为在激发位置处在样品中产生超声波信号的激发束; 入射在激发位置处的样品上的询问光束，询问光束从样品返回的指示所生成的超声信号的部分; 光学系统，其将至少一个激发光束和询问光束聚焦在低于样品表面的焦点; 以及检测器，其检测询问光束的返回部分。

公开(公告)号：US20160084766A1

公开(公告)日：2016-03-24

申请号：US14861570

申请日：2015-09-22

Applicant: Praveen Cheriyan Ashok ,  Gajendra Pratap Singh ,  Kishan Dholakia

Inventor： Praveen Cheriyan Ashok ,  Gajendra Pratap Singh ,  Kishan Dholakia

IPC: G01N21/65 ,  G01N21/64 ,  B01L3/00

CPC classification number: G01N33/146 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2300/16 ,  G01J3/0218 ,  G01N21/05 ,  G01N21/64 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/651 ,  G01N2201/0846

Abstract: A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.

Abstract translation: 一种拉曼光谱检测装置，包括至少一个微流体样品通道; 用于激发拉曼信号的至少一个激励波导和用于收集拉曼信号的至少一个收集波导。 激发波导的输出和收集波导的输入直接位于微流体样品通道中。

公开(公告)号：US20150268216A1

公开(公告)日：2015-09-24

申请号：US14599901

申请日：2015-01-19

Applicant: Sandia Corporation

Inventor： Marcus Alexander Chavez ,  Timothy T. Covert ,  Michael David Willis

IPC: G01N33/22 ,  G01P3/36 ,  G01N21/77 ,  G01D5/26

CPC classification number: G01N33/227 ,  G01D5/268 ,  G01N21/17 ,  G01N21/45 ,  G01N2201/06113 ,  G01N2201/0846 ,  G01N2201/088 ,  G01P3/36

Abstract: Sensor systems including an interferometer system are disclosed herein. In a general embodiment, the sensor system includes an optical fiber that is embedded into a sample, where the optical fiber has a reflective tip. The optical fiber is optically coupled to a sensor and a detector of the laser interferometer system. The sensor system further includes a computing device or circuit that is configured to receive electrical signals generated by the detector. The laser source is configured to emit light, which is coupled into the optical fiber. The light travels through the optical fiber until the light reaches the reflective tip, where it is reflected back through the optical fiber. The detector is impacted by the reflected light, and generates an electrical signal based upon the reflected light. The computing device generates a value that is indicative of a behavior of the sample based upon the electrical signal.

Abstract translation: 本文公开了包括干涉仪系统的传感器系统。 在一般实施例中，传感器系统包括嵌入样品中的光纤，其中光纤具有反射尖端。 光纤光学耦合到传感器和激光干涉仪系统的检测器。 传感器系统还包括被配置为接收由检测器产生的电信号的计算设备或电路。 激光源被配置为发射光，其耦合到光纤中。 光线穿过光纤直到光到达反射尖端，在那里它被光纤反射回来。 检测器受到反射光的影响，并根据反射光产生电信号。 计算设备基于电信号产生指示样本的行为的值。

公开(公告)号：US20150247794A1

公开(公告)日：2015-09-03

申请号：US14631917

申请日：2015-02-26

Applicant: ASL Analytical, Inc.

Inventor： Jonathon Todd Olesberg ,  Mark Allen Arnold ,  Gary Wray Small ,  Edwin John Koerperick ,  Christine Esther Evans

IPC: G01N21/359 ,  G01N21/3577

CPC classification number: C12Q3/00 ,  G01N21/314 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/51 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/399 ,  G01N2201/067 ,  G01N2201/0846

Abstract: A system and method for continuous, real-time process monitoring and control by means of near-infrared (NIR) spectroscopy provides analysis of static or flowing fluid streams which may range from clear to highly optically dense, including fluids primarily of aqueous composition. A NIR source passes through a wavelength selector to select one or more spectral segments, which are passed through the fluid stream at a fluid sampling interface and received at a sensor. A wavelength reference material is positioned in the optical path for calibration. Quantification of a plurality of characteristics or parameters of a fluid and suspended solids or cells contained therein may be performed. An all-solid-state implementation of the optical system ensures high robustness in laboratory and industrial settings.

Abstract translation: 通过近红外（NIR）光谱进行连续，实时过程监测和控制的系统和方法提供了静态或流动的流体流的分析，其可以从清楚到高度光密度，包括主要是含水组成的流体。 NIR源通过波长选择器以选择一个或多个光谱段，其在流体采样接口处通过流体流并在传感器处接收。 波长参考材料位于用于校准的光路中。 可以对包含在其中的流体和悬浮固体或细胞的多个特征或参数进行定量。 光学系统的全固态实现确保了实验室和工业环境中的高稳定性。

公开(公告)号：US20150247791A1

公开(公告)日：2015-09-03

申请号：US14631914

申请日：2015-02-26

Applicant: ASL Analytical, Inc.

Inventor： Edwin John Koerperick ,  Jonathon Todd Olesberg ,  Christine Esther Evans ,  Mark Allen Arnold ,  Gregory Allan Brower

IPC: G01N21/03 ,  G01N21/359

CPC classification number: G01N21/05 ,  A61M1/3693 ,  A61M1/3696 ,  G01N15/1404 ,  G01N21/0332 ,  G01N21/359 ,  G01N2021/0321 ,  G01N2021/0364 ,  G01N2021/054 ,  G01N2201/0846

Abstract: An optical apparatus with a single-use, disposable fluid flow cartridge and cell and associated optical interface is employed in determining characteristics of a fluid and/or suspended materials or cells contained therein which are introduced into the apparatus. The optical interface communicates electromagnetic radiation from an optical instrument through the fluid within the cell and to an appropriate sensor within the optical instrument. The interaction of the electromagnetic radiation with the fluid is measured by the signal generated by the sensor. Fluid present within the cell may be static or flowing, allowing both discrete sample measurements and monitoring of continuous processes.

Abstract translation: 使用具有一次性一次性流体流动筒和细胞和相关联的光学界面的光学装置来确定被引入到装置中的流体和/或其中包含的悬浮材料或细胞的特性。 光学接口将来自光学仪器的电磁辐射通过细胞内的流体传递到光学仪器内的适当的传感器。 通过传感器产生的信号来测量电磁辐射与流体的相互作用。 存在于电池内的流体可以是静态的或流动的，允许离散的样品测量和连续过程的监测。

公开(公告)号：US09057637B2

公开(公告)日：2015-06-16

申请号：US12445865

申请日：2007-10-16

Applicant: Gert Krammer

Inventor： Gert Krammer

IPC: G01J1/04 ,  G01N15/06 ,  G01F23/292 ,  G01D5/353 ,  G01N21/00 ,  G01N21/41

CPC classification number: G01F23/292 ,  G01D5/35303 ,  G01N21/00 ,  G01N21/4133 ,  G01N2201/0846

Abstract: A method and a device for optically determining state variables inside a container (1) for liquefied gases. In the method and device, light emitted by an illumination unit (2) travels within an optical waveguide (7, 9) to a contact point (33) with the content of the container (1) and is partially reflected there, the intensity of the reflected light is measured by an image sensor (4), and a state variable is determined from the intensity. In order to create a comprehensive “image” of the state variables in the container and of the container content, several optical waveguides (29, 29′) are guided to contact points (33) which are distributed within the container (1) and form measurement points (9.1, 9.2, 9.3, . . . , 9.n). Locally assigned state variables (refractive index, density, temperature, etc.) of the container content are determined from the measured values obtained at the measurement points (9.1, 9.2, 9.3, . . . , 9.n) and are evaluated along with the spatial coordinates of the measurement points (9.1, 9.2, 9.3, . . . , 9.n) in the container (1).

Abstract translation: 一种用于光学地确定用于液化气体的容器（1）内的状态变量的方法和装置。 在该方法和装置中，由照明单元（2）发射的光在容器（1）的内容物的光波导（7,9）内移动到接触点（33），并在其上部分反射， 反射光由图像传感器（4）测量，并根据强度确定状态变量。 为了创建容器和容器内容中的状态变量的综合“图像”，几个光波导（29,29'）被引导到分配在容器（1）内的接触点（33）并形成 测量点（9.1，9.2，9.3，...，9.n）。 从测量点（9.1,9.2,9.3，...，9.n）获得的测量值确定容器含量的局部分配状态变量（折射率，密度，温度等），并与 容器（1）中的测量点（9.1,9.2,9.3，...，9.n）的空间坐标。

公开(公告)号：US20150125345A1

公开(公告)日：2015-05-07

申请号：US14396388

申请日：2013-03-12

Applicant: AVL EMISSION TEST SYSTEMS GMBH

Inventor： Norbert Kreft

IPC: G01N21/76 ,  G01N33/00

CPC classification number: G01N21/766 ,  G01N33/0037 ,  G01N2201/0636 ,  G01N2201/0806 ,  G01N2201/084 ,  G01N2201/0846 ,  Y02A50/245

Abstract: A device for determining a concentration of at least one gas in a sample gas stream includes an analysis chamber, a detector, and a connecting channel. The analysis chamber is configured to have the sample gas stream and a reaction gas stream be introduced therein. The sample gas stream and the reaction gas stream are mixed to a gas mixture which reacts so as to emit an optical radiation. The detector is configured to measure the optical radiation. The connecting channel is configured to connect the analysis chamber to the detector. The connecting channel is configured as a light conductor extending from the analysis chamber to the detector.

Abstract translation: 用于确定样品气流中的至少一种气体的浓度的装置包括分析室，检测器和连接通道。 分析室被构造成具有样品气流并且反应气流被引入其中。 将样品气流和反应气流混合到反应以发射光辐射的气体混合物中。 检测器被配置成测量光辐射。 连接通道被配置为将分析室连接到检测器。 连接通道被配置为从分析室延伸到检测器的光导体。

公开(公告)号：US08804125B2

公开(公告)日：2014-08-12

申请号：US13583612

申请日：2011-02-10

Applicant: Osamu Kashiwazaki ,  Naoki Izumiya ,  Yuichi Atarashi

Inventor： Osamu Kashiwazaki ,  Naoki Izumiya ,  Yuichi Atarashi

IPC: G01N21/00 ,  G01N21/55

CPC classification number: G01N21/553 ,  G01N21/31 ,  G01N21/55 ,  G01N21/75 ,  G01N2021/755 ,  G01N2021/7773 ,  G01N2201/0846

Abstract: In order to calculate and specify a valley wavelength easily and in a short period of time, a detection device for intermolecular interaction is disclosed that is equipped with a detector provided with a ligand, a white light source that irradiates the detector with white light, a spectrometer that detects the light reflected from the detector, and a control device that controls the white-light source and the spectrometer, wherein the aforementioned control device obtains a reflection spectrum by calculating the reflectivity over a fixed wavelength interval, approximates the aforementioned reflection spectrum as a high-dimensional function, selects a wavelength interval comprising the minimum reflectivity from the aforementioned high-dimensional function, approximates the aforementioned high-dimensional function with the aforementioned wavelength interval as a quadratic function of a lower order, and obtains a solution by which the aforementioned quadratic function is differentiated with respect to the wavelength and the value thereof becomes 0.

Abstract translation: 为了容易地并且在短时间内计算和指定谷波长，公开了一种分子间相互作用的检测装置，其具有配备有配体的检测器，用白光照射检测器的白色光源， 检测从检测器反射的光的光谱仪，以及控制白光源和光谱仪的控制装置，其中上述控制装置通过计算固定波长间隔的反射率来获得反射光谱，将上述反射光谱近似为 高维函数从上述高维函数中选择包含最小反射率的波长间隔，将上述具有上述波长间隔的高维函数近似为低次的二次函数，并获得解 上述二次函数是微分的 相对于波长，其值为0。

公开(公告)号：US20140178938A1

公开(公告)日：2014-06-26

申请号：US13936685

申请日：2013-07-08

Applicant: Forensic Science Service Limited ,  The Arizona Board of Regents acting for and on behalf of Arizona State University

Inventor： Frederic ZENHAUSERN ,  Alan NORDQUIST ,  Ralf LENIGK ,  Cedric HURTH ,  Jianing YANG ,  Xiaojia CHEN ,  Matthew ESTES ,  John LEE-EDGHILL ,  Nina MORAN ,  Andrew HOPWOOD ,  Pieris KOUMI ,  Zhi CAI

IPC: C12Q1/68

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/502738 ,  B01L7/52 ,  B01L7/525 ,  C12Q1/6806 ,  C25B9/00 ,  G01N1/10 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44791 ,  G01N2021/6484 ,  G01N2201/062 ,  G01N2201/0846 ,  Y10T436/143333

Abstract: A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.

Abstract translation: 提供了一种方法和设备结构，其使得能够相对于在其中提供诸如PCR的一系列过程的设备来收集和分离归档样本。 提供了一种室结构和使用方法，其中通过控制通过各种通道的相对阻力获得受控和精确的体积。