公开(公告)号：US11442038B2

公开(公告)日：2022-09-13

申请号：US16007624

申请日：2018-06-13

Applicant: Agilent Technologies, Inc.

Inventor： Bruce R. Boeke ,  Martin Chris Foster ,  Thomas J. Kurt ,  Scott Stueckradt ,  Steven J. Lasky

IPC: G01N27/447 ,  G01N35/04

Abstract: The invention is an improved multiplex capillary electrophoresis instrument or module with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. An additional mechanical stage moves the array from side-to-side. The x-z stage, coupled with the additional array stage allows the system to sample all wells of a 384 well plate with a 96-capillary array. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress.

公开(公告)号：US20220283129A1

公开(公告)日：2022-09-08

申请号：US17631924

申请日：2020-07-30

Applicant: Agilent Technologies, Inc.

Inventor： Dwight Robert Stoll ,  Konstantin Shoykhet ,  Thomas Ortmann ,  Stephan Buckenmaier ,  Sascha Lege

IPC: G01N30/46

Abstract: A fluid processing apparatus includes a first fluid processing unit and a second fluid processing unit. A fluid unit is fluidically coupled to the first fluid processing unit and includes a first buffering unit configured for buffering fluid, and/or a mask flow source configured for providing a mask fluid or a flow thereof. A first coupling point is fluidically coupled between the first fluid processing unit and the fluid unit. A modulation unit is configured, selectively, for withdrawing fluid from the first coupling point, or for transferring withdrawn fluid into the second fluid processing unit. The apparatus may be utilized for chromatography.

公开(公告)号：US20220242896A1

公开(公告)日：2022-08-04

申请号：US17613463

申请日：2020-06-06

Applicant: Agilent Technologies, Inc.

Inventor： Francis T. Haxo

IPC: C07H7/033 ,  G01N33/58

Abstract: The present invention provides methods and kits to improve the signal from sialic acids labeled with the dye 1, 2-diamino-4, 5-methylenedioxybenzene (“DMB”). The methods include labeling the sialic acids with DMB in an aqueous solution comprising the amino acid glycine, with pH adjusted to 1.5-3.2 by an acid, such as phosphoric acid or hydrochloric acid, and a reductant.

公开(公告)号：US20220220852A1

公开(公告)日：2022-07-14

申请号：US17607363

申请日：2019-04-30

Applicant: Agilent Technologies, Inc.

Inventor： Ronald J. Forni

IPC: F01C21/02 ,  F04C18/02 ,  F04C29/02 ,  F04C27/00

Abstract: A vacuum scroll pump having an inlet portion having a pump inlet, and an exhaust portion having a pump outlet; a frame; a stationary scroll plate fixed to the frame and comprising a stationary plate comprising at least one stationary scroll blade; an orbiting scroll plate comprising an orbiting plate comprising at least one orbiting scroll blade projecting axially from a front side of the orbiting plate toward the stationary plate; a drive mechanism supported by the frame and operatively connected to the orbiting scroll plate so as to cause the orbiting scroll plate to orbit about a longitudinal axis of the vacuum scroll pump and thereby pump a process gas; a double-sided thrust bearing supporting the orbiting scroll plate; and a bellows which isolates the process gas from the drive mechanism.

公开(公告)号：US20220214334A1

公开(公告)日：2022-07-07

申请号：US17606915

申请日：2020-04-30

Applicant: Agilent Technologies, Inc.

Inventor： Andres Guerrero Navarro

IPC: G01N33/533 ,  G01N30/06

Abstract: The present invention provides methods to improve the sensitivity of detecting glycosylamines released from glycoconjugates, such as glycoproteins or glycopeptides, by enzymatic digestion when labeling them with amine-reactive dyes.

公开(公告)号：US11355327B2

公开(公告)日：2022-06-07

申请号：US16719812

申请日：2019-12-18

Applicant: Agilent Technologies, Inc.

Inventor： Cristian Maccarrone ,  Chiara Paolini ,  Enrica Carbonero ,  Paolo Manassero

IPC: H01J41/12

Abstract: An ion pump with a housing enclosing an interior, a gas inlet having a through-hole extending into the interior of the ion pump, at least one cathode, at least one anode positioned in proximity to the at least one cathode, a magnet disposed on an opposite side of the at least one cathode from the anode, and a blocking shield disposed between the gas inlet and the at least one cathode. The blocking shield is electrically connected to the at least one anode. An associated method installs the blocking shield by inserting components of the blocking shield assembly through the gas inlet, and assembling (inside the interior of the ion pump) the inserted components to form the blocking shield.

公开(公告)号：US20220170471A1

公开(公告)日：2022-06-02

申请号：US17540199

申请日：2021-12-01

Applicant: Agilent Technologies, Inc.

Inventor： Federico Terminio ,  Simone Cau

IPC: F04D19/04

Abstract: A vacuum pump includes a housing, a rotatable shaft extending in an axial direction within the housing, a first pumping arrangement including a first stator arrangement and a first rotor arrangement, and a second pumping arrangement including a second stator arrangement and a second rotor arrangement. The vacuum pump further includes a spacer arranged between the first pumping arrangement and the second pumping arrangement. The spacer is coupled between the first stator arrangement and the second stator arrangement and is configured to provide a defined elasticity in the axial direction allowing an elastic deformation of the spacer in the axial direction.

公开(公告)号：US11346822B2

公开(公告)日：2022-05-31

申请号：US16409463

申请日：2019-05-10

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Daniel Thielsch

IPC: G01N30/20 ,  B01D15/14 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36 ,  G01N30/32

Abstract: A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

公开(公告)号：US11342169B2

公开(公告)日：2022-05-24

申请号：US16842988

申请日：2020-04-08

Applicant: Agilent Technologies, Inc.

Inventor： Michael Schoessow

IPC: H01J49/02 ,  H03F3/45 ,  H01J49/40 ,  H01J49/42

Abstract: In one embodiment, a power source for providing high-voltage radio-frequency (RF) energy to an instrument such as a mass spectrometer includes an RF power amplifier having an output, an oscillating RF signal generator configured to provide first and second RF signals respectively oscillating at first and second frequencies to the RF power amplifier, and a step-up circuit for magnifying the RF power amplifier output. The step-up circuit includes an LC resonator network tuned to the first and second frequencies, and an output for providing the magnified voltage to a rod assembly of the mass spectrometer.

公开(公告)号：US20220154263A1

公开(公告)日：2022-05-19

申请号：US17588023

申请日：2022-01-28

Applicant: Agilent Technologies, Inc.

Inventor： Steen Hauge Matthiesen

IPC: C12Q1/6841 ,  C12Q1/6832

Abstract: The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.