公开(公告)号：US20240083955A1

公开(公告)日：2024-03-14

申请号：US18482262

申请日：2023-10-06

Applicant: Spiber Inc. ,  Kojima Industries Corporation

Inventor： Junichi Sugahara ,  Keisuke Morita ,  Hiroyuki Nakamura

IPC: C07K14/435 ,  D01D10/00 ,  D01F4/02

CPC classification number: C07K14/43518 ,  D01D10/00 ,  D01F4/02

Abstract: The present invention relates to a highly contracted artificial fibroin fiber including a modified fibroin, in which a contraction percentage defined by the following equation exceeds 7%.


Contraction percentage={1−(length of contracted artificial fibroin fiber/length of artificial fibroin fiber before being brought into contact with water after spinning)}×100 (%)

公开(公告)号：US11851684B2

公开(公告)日：2023-12-26

申请号：US16649804

申请日：2018-09-28

Applicant: Spiber Inc.

Inventor： Masahiro Murakami

IPC: C12N5/10 ,  C12N15/11 ,  C12P21/02

CPC classification number: C12N5/10 ,  C12N15/111 ,  C12P21/02

Abstract: Disclosed is an expression cassette comprising, in a 5′ to 3′ direction of a sense strand, a promoter, and a first nucleic acid, a terminator and a second nucleic acid operably linked to the promoter, wherein the first nucleic acid and the second nucleic acid each contain at least one gene.

公开(公告)号：US20230248020A1

公开(公告)日：2023-08-10

申请号：US18009023

申请日：2021-06-08

Applicant: Spiber Inc.

Inventor： Yu Chun Chuang ,  Arin Naidu

IPC: A23J3/22 ,  A23J3/04 ,  A23L13/40 ,  A23J3/28 ,  C07K14/435

CPC classification number: A23J3/227 ,  A23J3/04 ,  A23L13/424 ,  A23J3/28 ,  C07K14/43586

Abstract: The present invention relates to a meat-like food composition containing: at least one raw material selected from the group consisting of a meat raw material and a meat substitute composition raw material; and a sheet containing a purified protein.

公开(公告)号：US11692015B2

公开(公告)日：2023-07-04

申请号：US16633589

申请日：2018-07-25

Applicant: Spiber Inc. ,  Riken

Inventor： Keisuke Morita ,  Yunosuke Abe ,  Takehisa Maekawa ,  Koichi Kotaka ,  Junichi Sugahara ,  Keiji Numata

IPC: C07K14/435 ,  C12N15/63 ,  D01F4/02

CPC classification number: C07K14/43518 ,  C12N15/63 ,  D01F4/02

Abstract: The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A)nmotif-REP]m or Formula 2: [(A)nmotif-REP]m−(A)n motif, in which the domain sequence has an amino acid sequence with a reduced content of a glutamine residue equivalent to an amino acid in which one or a plurality of glutamine residues in REP are deleted or substituted with other amino acid residues, as compared with a naturally occurring fibroin.

公开(公告)号：US20230095432A1

公开(公告)日：2023-03-30

申请号：US17795749

申请日：2021-01-29

Applicant: Spiber Inc.

Inventor： Yu Chun Chuang ,  Li Jiang ,  Arin Naidu

IPC: A23J3/14 ,  A23J3/22 ,  C07K14/415 ,  C07K14/435

Abstract: To provide a meat substitute composition having a texture and sensory properties closer to those of real meat than a meat substitute composition in the related art, the present disclosure provides meat substitute composition containing a polypeptide that satisfies the following (1) or (2):
(1) number of amino acid residues is 150 or more, an alanine residue content is 12 to 40%, and a glycine residue content is 11 to 55%; or
(2) an amino acid residue content of at least one type selected from the group consisting of serine, threonine, and tyrosine, an alanine residue content, and a glycine residue content account for 56% or more altogether.

公开(公告)号：US20220235099A1

公开(公告)日：2022-07-28

申请号：US17614058

申请日：2020-05-28

Applicant: Spiber Inc.

Inventor： Hironari Kamikubo ,  Yugo Hayashi ,  Takehiro Sato

IPC: C07K14/435 ,  D01F4/02

Abstract: Provided is a structural protein microbody that functions as a core for forming a protein nanofiber. There is provided a structural protein microbody including a structural protein, in which the structural protein microbody satisfies at least two of the following (i) to (iii): (i) a peak is present within a range of 480 to 500 nm in a fluorescence intensity measurement by thioflavin T staining; (ii) a peak is present in a region where Q is 0.15 or less in a modified Kratky plot of small angle X-ray scattering (SAXS); and (iii) the structural protein microbody is an aggregate of two or more structural protein molecules.

公开(公告)号：US11286286B2

公开(公告)日：2022-03-29

申请号：US16491633

申请日：2018-03-05

Applicant: Spiber Inc. ,  Kojima Industries Corporation

Inventor： Takashi Morinaga ,  Takehisa Maekawa

IPC: D01D5/06 ,  D01D5/14 ,  D01D7/00 ,  D01D10/02 ,  D01F4/00 ,  D02J1/22 ,  D02J13/00 ,  D04H3/015 ,  D06B3/04 ,  D06M11/05 ,  D06M11/84 ,  F26B13/00 ,  F26B13/12 ,  C07K14/435 ,  D01F4/02 ,  D06M101/10

Abstract: The present invention relates to a method for manufacturing a protein fiber, including an extension and contraction step of contracting or extending a protein raw fiber containing a protein by bringing the protein raw fiber into contact with a liquid or vapor; and a drying step of drying the protein raw fiber that has undergone the extension and contraction step while adjusting a length of the protein raw fiber to an arbitrary length.

公开(公告)号：US20220074077A1

公开(公告)日：2022-03-10

申请号：US17279081

申请日：2019-09-27

Applicant: Spiber Inc.

Inventor： Yunosuke Abe ,  Masato Matsuo ,  Shota Togashi

IPC: D01F4/02 ,  D01D11/00

Abstract: The present invention provides a modified fibroin fiber having a shrinkage history of being irreversibly shrunk after spinning, the modified fibroin fiber containing modified fibroin, wherein a fiber diameter of a raw material fiber before being irreversibly shrunk exceeds 25 μm.

公开(公告)号：US20210395317A1

公开(公告)日：2021-12-23

申请号：US17279564

申请日：2019-09-30

Applicant: Spiber Inc.

Inventor： Yunosuke Abe ,  Hirotada Ando ,  Koichi Kotaka

IPC: C07K14/435 ,  C07K14/47 ,  D01D5/06 ,  D01F4/00 ,  D01F4/02

Abstract: Disclosed is a method for producing a protein fiber, the method including: bringing a spinning dope containing a protein and an organic solvent into contact with a coagulation liquid to coagulate the protein, wherein a content of the protein in the spinning dope is more than 10% by mass based on a total amount of the spinning dope, and the coagulation liquid contains water or an aqueous solution of pH 0.25 or more and pH 10.00 or less.

公开(公告)号：US11174572B2

公开(公告)日：2021-11-16

申请号：US16326081

申请日：2017-07-24

Applicant: RIKEN ,  SPIBER INC.

Inventor： Keiji Numata ,  Kousuke Tsuchiya ,  Junichi Sugahara ,  Takaoki Ishii ,  Hongfang Chi

IPC: D01F4/02 ,  D01F4/00 ,  D01D1/02 ,  A61L27/22 ,  D01D5/16 ,  D01F1/10 ,  D01F6/68

Abstract: Provided are a composite molding composition such as a composite film and a composite fiber that have properties such as an improved tensile strength, strain and toughness as a result of blending a peptide or polyamino acid having a β-sheet structure with a natural or artificially modified fibroin-derived protein; a method for producing such composite molding composition; and a method for improving the physical properties of a composite molding composition containing a fibroin-derived protein.