Abstract:
A colorimetric optical sensor device includes a broadband light source configured to emit a light that is exposed to a fluid in a vessel. At least a portion of the light is reflected off of the fluid and received by an optical spectrometer. The optical spectrometer analyzes at least a portion of the received light to determine a main wavelength of the light. A controller correlates the main wavelength to a corresponding hematocrit or free hemoglobin concentration and generates an output indicative of the hematocrit or the free hemoglobin concentration of the fluid. The hematocrit or free hemoglobin concentration information may be used by a separation assembly in which the colorimetric optical sensor device may be incorporated to modify a separation procedure in which the monitored fluid is to be separated or is a component or constituent of a previously separated biological fluid.
Abstract:
Systems and methods are provided for separating blood into two or more components. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case, which allows for fluid separation by two different methods. Depending on the separation procedure to be carried out, the fluid flow circuit paired with the blood separation device may include only one separation chamber configured to be mounted to the centrifugal separator or spinning membrane separator drive unit or two separation chambers, with one being mounted to the centrifugal separator and the other to the spinning membrane separator drive unit. The system may be used to separate and collect any combination of red blood cells, plasma, and platelets.
Abstract:
The present disclosure relates to systems and methods for the separation of blood into blood products and, more particularly, to systems and methods that permit automated recovery of white blood cells after producing a leukocyte-reduced blood product.
Abstract:
System, apparatus and method for opening a heat-bonded connection formed between two hollow, flexible thermoplastic conduits. A pressure difference is created between the inside of at least one of the conduits and the ambient atmosphere sufficient to cause expansion of a wall of the tubing conduit in the vicinity of a frangible portion at least partially blocking the connection to disrupt the frangible portion and reduce the blocking.
Abstract:
Certain examples describe systems and methods for increasing plasma extracted from donor blood. An example method includes receiving blood extracted from a donor connected to a blood collection machine. The example method includes filtering the blood using a filtration device to remove at least a portion of plasma included in the blood to separate the plasma removed from remaining blood. The example method includes routing the plasma removed for collection. The example method includes re-filtering the remaining blood using a or the filtration device to remove additional plasma from the remaining blood. The example method includes routing the additional plasma removed for collection.
Abstract:
A fluid processing device includes a detection assembly having a light source, an adjustment system, and a light detector. The light source is associated with a component of the fluid processing device, provided in an initial position with respect to said component of the fluid processing device, and configured to emit a light. The adjustment system is associated with the light source and configured to adjust the position of the light source. The light detector is configured to receive at least a portion of the light from the light source and generate a signal indicative of the amount of light received by the light detector. The fluid processing device further includes a controller configured to receive the signal from the light detector and control the adjustment system to move the light source to a monitoring position based at least in part on the signal.
Abstract:
A blood processing device includes a pump system, a valve system, a separator and a controller configured to execute a plasma collection stage of a blood processing procedure by actuating the pump system and the valve system to convey blood from a blood source into the separator, actuating the separator to separate the blood into at least plasma and red blood cells, in a transfusion plasma collection step actuating the pump system and the valve system to convey a first volume of separated plasma out of the separator along a first flow path for transfusion plasma collection, and in a fractionation plasma collection step of the plasma collection stage, actuating the pump system and valve system to convey a second volume of the separated plasma out of the separator along a second flow path for fractionation plasma collection.
Abstract:
A fluid processing device includes a controller, a centrifuge configured to receive and rotate a continuous-flow centrifuge chamber, a pump system, an optical detection assembly, and a pressure sensor. The controller executes a priming procedure in which a priming fluid is conveyed into the centrifuge chamber while the chamber is being rotated by the centrifuge, which moves air out of the chamber via a low-g outlet conduit. Upon detecting priming fluid exiting the centrifuge chamber via the low-g outlet conduit, the chamber is rotated at a higher rate to attempt to move any remaining air out of the chamber via the low-g outlet conduit. The controller then determines, based on signals from the optical detection assembly and pressure sensor, whether there is any air remaining in the centrifuge chamber. If so, the rotational rate is alternately decreased and increased until all the air has been cleared from the centrifuge chamber.
Abstract:
A biological fluid processing system and a method of executing a biological fluid processing procedure is disclosed. The biological fluid processing system includes a processing device, a scanner, and a data management system. The processing device includes a display screen and a controller which operates the processing device to implement a biological fluid processing procedure having a plurality of steps. The controller displays an image on the display screen. The scanner interacts with the device screen to retrieve data from the image and transmit the data to the data management system. The scanner and/or the data management system transmit a signal to the controller based on the data. The controller initiates at least one step of the biological fluid processing procedure upon receiving the signal.
Abstract:
A biological fluid processing device includes pump and valve systems, a centrifuge and a controller. The controller is configured to operate the pump and valve systems to convey buffy coat into the centrifuge, operate the centrifuge at a first rotation rate to separate the buffy coat into platelets and red blood cells, operate the pump and valve systems to convey a first portion of the separated platelets from the centrifuge for collection, and operate the pump and valve systems to convey the separated red blood cells from the centrifuge for collection. The controller is further configured to operate the centrifuge at one or more second rotation rates lower than the first rotation rate, operate the pump and valve systems to convey the collected red blood cells into the centrifuge, and operate the pump and valve systems to convey a second portion of the platelets from the centrifuge for collection.