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    Synthetic apelin mimetics for the treatment of heart failure
    74.
    发明授权
    Synthetic apelin mimetics for the treatment of heart failure 有权
    用于治疗心力衰竭的合成apelin模拟物

    公开(公告)号：US08673848B2

    公开(公告)日：2014-03-18

    申请号：US13747621

    申请日：2013-01-23

    Applicant: Frédéric Zecri ,  Andrei Golosov ,  Philipp Grosche ,  Kayo Yasoshima ,  Hongjuan Zhao ,  Qi-Ying Hu ,  Hidetomo Imase ,  David Thomas Parker

    Inventor： Frédéric Zecri ,  Andrei Golosov ,  Philipp Grosche ,  Kayo Yasoshima ,  Hongjuan Zhao ,  Qi-Ying Hu ,  Hidetomo Imase ,  David Thomas Parker

    IPC: C07K7/08 ,  C07K7/60 ,  C07K7/56

    CPC classification number: A61M16/0816 ,  A61K38/00 ,  A61K38/10 ,  A61M16/0066 ,  A61M16/201 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2205/35 ,  A61M2205/502 ,  C07K7/08 ,  C07K7/56 ,  C07K7/60

    Abstract: The invention provides a synthetic polypeptide of Formula I′: or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

    Abstract translation: 本发明提供式I'的合成多肽：或其酰胺，酯或其盐，其中X1，X2，X3，X4，X5，X6，X7，X8，X9，X10，X11，X12和X13被定义 这里。 多肽是APJ受体的激动剂。 本发明还涉及制备本发明多肽的方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，Brugada综合征，室性心动过速，动脉粥样硬化 ，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，保水，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（ 包括晒伤）和先兆子痫。 本发明还提供药理活性剂和药物组合物的组合。

    Ventilation Mask with Integrated Piloted Exhalation Valve And Method of Ventilating a Patient Using the Same
    75.
    发明申请
    Ventilation Mask with Integrated Piloted Exhalation Valve And Method of Ventilating a Patient Using the Same 有权
    具有综合引导呼气阀的通气面罩及使用该呼气阀的患者通气方法

    公开(公告)号：US20130255684A2

    公开(公告)日：2013-10-03

    申请号：US13431827

    申请日：2012-03-27

    Applicant: Breathe Technologies, Inc.

    Inventor： Todd W. Allum ,  Joseph Cipollone ,  George A. Kassanis

    IPC: A61M16/06 ,  A61M16/00 ,  A61M16/20

    CPC classification number: A61M16/208 ,  A61M16/0003 ,  A61M16/0605 ,  A61M16/0622 ,  A61M16/0666 ,  A61M16/0833 ,  A61M16/0858 ,  A61M16/0875 ,  A61M16/1045 ,  A61M16/201 ,  A61M16/207 ,  A61M2016/0027 ,  A61M2205/3334

    Abstract: In accordance with the present invention, there is provided a mask for achieving positive pressure mechanical ventilation (inclusive of CPAP, ventilator support, critical care ventilation, emergency applications), and a method for a operating a ventilation system including such mask. The mask of the present invention includes a piloted exhalation valve that is used to achieve the target pressures/flows to the patient. The pilot for the valve may be pneumatic and driven from the gas supply tubing from the ventilator. The pilot may also be a preset pressure derived in the mask, a separate pneumatic line from the ventilator, or an electro-mechanical control. Additionally, the valve can be implemented with a diaphragm or with a flapper.

    Abstract translation: 根据本发明，提供了一种用于实现正压机械通气（包括CPAP，呼吸机支架，重要护理通气，紧急应用）的面罩，以及用于操作包括这种面罩的通风系统的方法。 本发明的掩模包括用于实现目标压力/流向患者的导向呼气阀。 阀门的先导阀可以是气动的，并且来自呼吸机的气体供应管道驱动。 驾驶员也可以是在面罩中产生的预设压力，来自呼吸机的独立气动管路或机电控制。 此外，阀可以用隔膜或挡板来实现。

    VOLUME-ADJUSTABLE MANUAL VENTILATION DEVICE
    77.
    发明申请
    VOLUME-ADJUSTABLE MANUAL VENTILATION DEVICE 审中-公开

    公开(公告)号：US20130125894A1

    公开(公告)日：2013-05-23

    申请号：US13740060

    申请日：2013-01-11

    Applicant: ArtiVent Corporation

    Inventor： Ian Loren Halpern

    IPC: A61M16/00

    CPC classification number: A61M16/0078 ,  A61M16/0003 ,  A61M16/0084 ,  A61M16/06 ,  A61M16/0616 ,  A61M16/107 ,  A61M16/20 ,  A61M16/201 ,  A61M16/208 ,  A61M2016/0027 ,  A61M2205/3331 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583

    Abstract: Disclosed is a manually operable volume-adjustable ventilation device. The device includes a reservoir with an inlet mechanism, an outlet mechanism, and a volume adjuster configured to move a volume adjustment limit of the reservoir and change an expressed maximum volume of the reservoir. The reservoir has a body having a plurality of movable walls defining an enclosed volume. The reservoir has an uncompressed state and a compressed state. The walls of the reservoir are movable with respect to each other, such that moving the walls expresses the volume adjustment limit of the reservoir. The walls can be operably connected by movable structures configured such that two adjacent walls are configured to rotate around substantially orthogonal axes with respect to each other when the reservoir moves from an uncompressed to a compressed state. In some embodiments, the movable structures can be hinges, such as snap-fit assembly hinges. Methods of ventilating a patient that involve the device are also disclosed.

    MOUTHPIECE FOR CONTROLLED DELIVERY OF A BREATHING GAS
    78.
    发明申请
    MOUTHPIECE FOR CONTROLLED DELIVERY OF A BREATHING GAS 有权
    用于控制输送呼吸气体的方法

    公开(公告)号：US20130068229A1

    公开(公告)日：2013-03-21

    申请号：US13429705

    申请日：2012-03-26

    Applicant: Stefan SCHÄTZL

    Inventor： Stefan SCHÄTZL

    IPC: A61M16/20 ,  A61M16/00

    CPC classification number: A61M16/206 ,  A61M16/0057 ,  A61M16/0488 ,  A61M16/049 ,  A61M16/0875 ,  A61M16/20 ,  A61M16/201 ,  A61M2210/0625 ,  A61M2210/0637 ,  A61M2210/0643 ,  A62B9/06

    Abstract: The present invention relates to a mouthpiece for controlled delivery of a breathing gas including oxygen, preferably an increased ratio of oxygen with respect to ambient air, to the respiratory tracts of a user comprising a valve having two modes; a closed default mode, which substantially impedes any flow of the breathing gas through the valve; and an active open mode, which allows for a substantial flow of the breathing gas through the valve, wherein the open mode can be activated by the user manipulating the valve with his/her mouth. The invention also relates to the use of such a valve in a device for delivery of breathing gas and further to an apparatus for controlled delivery of the breathing gas to the respiratory tracts of a user. Finally, the invention also relates to a method for controlled delivery of the breathing gas to the respiratory tracts of a user.

    Abstract translation: 本发明涉及一种用于将包括氧的呼吸气体（优选氧气相对于环境空气的增加的比例）控制递送给包括具有两种模式的阀的使用者的呼吸道的接口管; 闭合的默认模式，其基本上阻止呼吸气体通过阀的任何流动; 以及主动打开模式，其允许呼吸气体通过阀的大量流动，其中打开模式可以由使用者用他/她的嘴操纵阀门来启动。 本发明还涉及这种阀在用于输送呼吸气体的装置中的用途，并且还涉及用于将呼吸气体控制输送到使用者呼吸道的装置。 最后，本发明还涉及用于将呼吸气体控制输送到使用者呼吸道的方法。

    System and method for guidance of anesthesia, analgesia and amnesia
    79.
    发明授权
    System and method for guidance of anesthesia, analgesia and amnesia 有权
    麻醉，止痛和健忘症指导系统和方法

    公开(公告)号：US08352023B2

    公开(公告)日：2013-01-08

    申请号：US13036730

    申请日：2011-02-28

    Applicant: Erwin R. John ,  Leslie S. Prichep

    Inventor： Erwin R. John ,  Leslie S. Prichep

    IPC: A61B5/04

    CPC classification number: A61B5/4821 ,  A61B5/01 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/024 ,  A61B5/04012 ,  A61B5/048 ,  A61B5/04845 ,  A61B5/08 ,  A61B5/4839 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/7275 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B5/746 ,  A61M5/00 ,  A61M5/1407 ,  A61M5/142 ,  A61M5/1723 ,  A61M16/01 ,  A61M16/06 ,  A61M16/0683 ,  A61M16/12 ,  A61M16/18 ,  A61M16/201 ,  A61M2016/0661 ,  A61M2202/048 ,  A61M2210/0618 ,  A61M2230/10

    Abstract: Described is a method and system which includes a first set of digital data generated by amplifying and digitizing brain waves of a patient before and after administration of initial doses of interventional agents to the patient and a second set of digital data generated by amplifying and digitizing brain waves of the patient during a medical procedure. In addition, the system includes a microprocessor computing separate trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure as a function of a comparison of the first and second sets of digital data, the indices including a Depth Index (DI), a Memory Index (MI) and Pain Index (PI), the DI corresponding to a depth of anesthesia of the patient, the PI corresponding to a sensitivity of the patient to pain and the MI corresponding to an ability of the patient to form and store memories. The system also includes a display outputting the trajectories for the at least two different indices of anesthetic state of the patient to a user for consideration in formulating subsequent dosages of the interventional agents to be administered to the patient.

    Abstract translation: 描述了一种方法和系统，其包括通过在向患者施用初始剂量的介入药剂之前和之后放大和数字化患者的脑波而产生的第一组数字数据和通过放大和数字化脑产生的第二组数字数据 在医疗过程中患者的波浪。 此外，该系统包括微处理器，用于根据第一和第二组数字数据的比较来计算在医疗过程期间患者的麻醉状态的至少两个不同指数的分离轨迹，所述指数包括深度指数 （DI），记忆指数（MI）和疼痛指数（PI），DI对应于患者的麻醉深度，PI对应于患者对疼痛的敏感性和对应于患者能力的MI 形成和存储回忆。 该系统还包括向用户输出用于患者的至少两个不同麻醉状态指标的轨迹的显示器，以便在制定待给予患者的介入剂的后续剂量时考虑。

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