Method and arrangement for the production of particles
    72.
    发明授权
    Method and arrangement for the production of particles 有权
    生产颗粒的方法和布置

    公开(公告)号:US08585943B2

    公开(公告)日:2013-11-19

    申请号:US12745072

    申请日:2008-12-01

    CPC classification number: B01J2/06 A61K9/1688 B01J2/04 B01J4/002 B01J19/26

    Abstract: A method for producing particles, from a substance, having predetermined size and/or morphology characteristics. The method consists of mixing within a spray nozzle a solution stream containing the substance in dissolved or dispersed form with a supercritical fluid stream. Spraying the mixture through a nozzle into a particle collecting chamber and there separating the particles. The characteristic feature is an additional step, providing a make-up agent (modifier) to the fluid stream, possibly combined with recycling of the fluid and/or performing the method essentially simultaneously in several spray nozzles. Additional features are also a production system comprising functions for performing the method above and the introduction of the make-up agent, recycling of the fluid and performing several runs essentially simultaneously in the same production system. Also a pharmaceutical formulation in which particles produced according to the method has been used for its manufacture.

    Abstract translation: 从具有预定尺寸和/或形态特征的物质制备颗粒的方法。 该方法包括在喷雾喷嘴内混合含有溶解或分散形式的物质与超临界流体流的溶液流。 将混合物通过喷嘴喷射到颗粒收集室中,并分离颗粒。 该特征是额外的步骤,为流体流提供补充剂(改性剂),可能与流体的再循环相结合,和/或在几个喷嘴中基本上同时进行该方法。 附加特征也是包括用于执行上述方法的功能和补充剂的引入,流体的再循环以及在同一生产系统中基本上同时执行几个运行的功能的生产系统。 还有一种药物制剂,其中根据该方法生产的颗粒已被用于其制造。

    APPARATUS AND METHOD FOR THE PRODUCTION OF TRISILYAMINE
    74.
    发明申请
    APPARATUS AND METHOD FOR THE PRODUCTION OF TRISILYAMINE 有权
    装置和方法生产三硝胺

    公开(公告)号:US20130224097A1

    公开(公告)日:2013-08-29

    申请号:US13847174

    申请日:2013-03-19

    Applicant: Voltaix, Inc.

    Inventor: Gary D. Miller

    Abstract: There is described an apparatus, a tubular laminar flow, plug flow reactor, for making silylamines and particularly trisilylamine (TSA) in high yields from ammonia gas and a monohalosilane gas. The apparatus can be a tubular flow reactor comprising a first portion of the reactor defining a gas entry zone, a second portion of the reactor defining a reaction zone and a third portion of the reactor defining a separation zone, the reaction zone providing a reactant contacting region. Trisilylamine can be recovered in the separation zone in a cold trap collection vessel.

    Abstract translation: 描述了用于从氨气和一卤硅烷气体高产率制备甲硅烷基胺,特别是三甲硅烷(TSA)的装置,管状层流,活塞流反应器。 该装置可以是管式流动反应器,其包括反应器的第一部分,限定气体进入区,反应器的第二部分限定反应区,反应器的第三部分限定了分离区,反应区提供反应物接触 地区。 三甲胺可以在冷阱收集容器中的分离区中回收。

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