BIOSENSING DEVICES AND METHODS OF USING AND PREPARING THE SAME
    74.
    发明申请
    BIOSENSING DEVICES AND METHODS OF USING AND PREPARING THE SAME 审中-公开
    生物传感装置及其使用和制备方法

    公开(公告)号:US20170058310A1

    公开(公告)日:2017-03-02

    申请号:US15120446

    申请日:2014-02-19

    Abstract: A biosensing device, as well as methods of forming a biosensing device and detecting presence of a biofilm are disclosed. The biosensing device may include a substrate, at least one radiation source on the substrate, at least one radiation detector on the substrate, and at least one reflector arranged on the substrate such that radiation emitted from the at least one radiation source is reflected toward the at least one radiation detector. The at least one radiation detector may be configured to detect an intensity of the radiation reflected from the at least one reflector. A biofilm growth on a portion of the at least one reflector may cause a change in the intensity of the radiation reflected from the at least one reflector relative to radiation reflected from the reflector in the absence of the biofilm growth.

    Abstract translation: 公开了一种生物传感装置,以及形成生物传感装置和检测生物膜存在的方法。 生物传感装置可以包括衬底,衬底上的至少一个辐射源,衬底上的至少一个辐射检测器和布置在衬底上的至少一个反射器,使得从至少一个辐射源发射的辐射朝向 至少一个辐射检测器。 所述至少一个辐射检测器可以被配置为检测从所述至少一个反射器反射的辐射的强度。 在不存在生物膜生长的情况下,至少一个反射器的一部分上的生物膜生长可导致从至少一个反射器反射的辐射的强度相对于从反射器反射的辐射的变化。

    SENSOR
    75.
    发明申请
    SENSOR 有权
    传感器

    公开(公告)号:US20160343775A1

    公开(公告)日:2016-11-24

    申请号:US15156953

    申请日:2016-05-17

    Abstract: According to one embodiment, a sensor includes a light emitter and a light sensor. The light emitter includes a first electrode, a second electrode, and a first light emitting layer. The second electrode is light-transmissive. The first light emitting layer is provided between the first electrode and the second electrode. The light sensor includes a third electrode, a fourth electrode, a fifth electrode, a first photoelectric conversion layer, and a second photoelectric conversion layer. the fourth electrode is light-transmissive. The fifth electrode is provided between the third electrode and the fourth electrode. The fifth electrode is light-transmissive. The first photoelectric conversion layer is provided between the third electrode and the fifth electrode. The second photoelectric conversion layer is provided between the fourth electrode and the fifth electrode.

    Abstract translation: 根据一个实施例,传感器包括光发射器和光传感器。 光发射器包括第一电极,第二电极和第一发光层。 第二电极是透光的。 第一发光层设置在第一电极和第二电极之间。 光传感器包括第三电极,第四电极,第五电极,第一光电转换层和第二光电转换层。 第四电极是透光的。 第五电极设置在第三电极和第四电极之间。 第五电极是透光的。 第一光电转换层设置在第三电极和第五电极之间。 第二光电转换层设置在第四电极和第五电极之间。

    Plasmonic dark field and fluorescence microscopy
    77.
    发明授权
    Plasmonic dark field and fluorescence microscopy 有权
    等离子体暗场和荧光显微镜

    公开(公告)号:US09304234B2

    公开(公告)日:2016-04-05

    申请号:US13418097

    申请日:2012-03-12

    Abstract: Plasmonic condensers for generating surface plasmon at an evanescent wave surface can include a substrate layer, a metal layer comprising the evanescent wave surface; and a media layer disposed between the metal layer and the substrate layer. The media layer can be active or passive and can include a source of radiation that interacts with the metal layer to create surface plasmons that are not substantially optically detectable as far field radiation until an interfering object is brought into proximity with the evanescent wave surface. When an interfering object such as a sample or specimen is brought into proximity with the evanescent wave surface, it causes coupling of at least some of the surface plasmons into propagating radiation detectable by an objective lens. Systems, methods, and the like are disclosed, as are features of a plasmonic meta-materials illuminator.

    Abstract translation: 用于在ev逝波表面产生表面等离子体激元的等离子体冷凝器可以包括基底层,包含ev逝波面的金属层; 以及设置在金属层和基底层之间的介质层。 介质层可以是有源的或无源的,并且可以包括与金属层相互作用的辐射源,以产生表面等离子体,这些表面等离激元不是远场光辐射,直到干扰物体接近于ev逝波面。 当诸如样品或样品的干扰物体与ev逝波表面接近时,其使至少一些表面等离子体激元耦合到由物镜可检测的传播辐射。 公开了系统,方法等,以及等离子体激元间材料照明器的特征。

    ILLUMINATION DEVICE
    78.
    发明申请
    ILLUMINATION DEVICE 有权
    照明装置

    公开(公告)号:US20150293339A1

    公开(公告)日:2015-10-15

    申请号:US14437508

    申请日:2013-10-22

    Abstract: An illumination device for an optical device, a microscope or a macroscope includes a first illumination source configured to emit light which is directed via an illumination beam path onto an object to be illuminated that is arranged in an object plane. At least one second illumination source is positionable in the illumination beam path, and is transparent or semitransparent as well as self-luminous. The at least one second illumination source is configured to allow light emitted from the first illumination source to pass through at least in part. The object plane having the object to be illuminated is configured to be illuminated both by the first and by the at least one second illumination source.

    Abstract translation: 用于光学装置,显微镜或宏观显微镜的照明装置包括:第一照明源,被配置为发射经由照明光束路径引导到被布置在物体平面中的被照射物体上的光。 至少一个第二照明源可定位在照明光束路径中,并且是透明的或半透明的以及自发光的。 至少一个第二照明源被配置为允许从第一照明源发射的光至少部分地通过。 具有被照明物体的物体被配置为由第一照明源和至少一个第二照明光源照亮。

    Apparatus and Method for Differentiating Multiple Fluorescence Signals by Excitation Wavelength
    79.
    发明申请
    Apparatus and Method for Differentiating Multiple Fluorescence Signals by Excitation Wavelength 审中-公开
    通过激发波长区分多个荧光信号的装置和方法

    公开(公告)号:US20150293024A1

    公开(公告)日:2015-10-15

    申请号:US14741319

    申请日:2015-06-16

    Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.

    Abstract translation: 提供一种用于通过激发波长区分多个可检测信号的装置和方法。 该装置可以包括可以例如在一个井中的样品保留区域中的样品发射相应的激发光波长或波长范围的光源。 样品可以包含两种或更多种可检测的标记,例如荧光染料,其中当荧光染料在靶组分存在下被激发时,其能够产生增加的可检测的发射。 可检测标记物可以具有与其它可检测标记物的范围重叠的激发波长范围和/或发射波长范围。 可以设置检测器,用于检测在至少一个其他标记的重叠波长范围内从第一标记发射的发射波长或波长范围。

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