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公开(公告)号：US20220275035A1
公开(公告)日：2022-09-01
申请号：US17672346
申请日：2022-02-15
Inventor： Peter Ulrichts , Christophe Blanchetot , Torsten Dreier , Johannes de Haard , E. Sally Ward Ober , Nicolas G. H. Ongenae
Abstract: Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions.
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公开(公告)号：US20220273779A1
公开(公告)日：2022-09-01
申请号：US17295152
申请日：2019-11-18
Inventor： Marc I. DIAMOND , Kenneth DROMBOSKY , Dailu CHEN , Victor MANON , Xiaohua LIU , Hamid MIRZAEI , Jaime VAQUER-ALICEA , Hilda MIRBAHA , Lukasz A. JOACHIMIAK
Abstract: The disclosure provides methods and compositions for treating and diagnosing tauopathies. More specifically, the disclosure relates to the identification of epitopes on tau and their use as vaccines or as reagents to generate monoclonal antibodies that can be used for both diagnosis and treatment of tau-related diseases.
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公开(公告)号：US11431470B2
公开(公告)日：2022-08-30
申请号：US16996061
申请日：2020-08-18
Applicant: The Board of Regents of The University of Texas System , The Regents of the University of California , Microsoft Technology Licensing, LLC
Inventor： Xiaoqian Jiang , Miran Kim , Yongsoo Song , Kristin Lauter
Abstract: A method, system and computer program product for performing computations on sensitive data while guaranteeing privacy. A service provider receives a first and a second ciphertext from a medical provider that homomorphically encrypts matrices A and B, respectively, using an encryption key, where the matrices A and B include medical data encoded as vectors. The service provider performs a homomorphic matrix multiplication on the first and second ciphertexts without decrypting the first and second ciphertexts. An encrypted result from the performed homomorphic matrix multiplication on the first and second ciphertexts is generated and transmitted to the medical provider to decrypt which matches a result of performing a matrix multiplication on unencrypted matrices A and B thereby enabling computations to be performed on the medical data in a secure manner.
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公开(公告)号：US11426448B2
公开(公告)日：2022-08-30
申请号：US16410789
申请日：2019-05-13
Applicant: NORTHWESTERN UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventor： Carol Podlasek , Samuel I. Stupp , Kevin McVary , Dan Harrington
IPC: A61K38/18 , A61P15/10 , C07K14/47 , A61K38/00 , C07K14/475
Abstract: Provided herein is technology relating to compositions comprising sonic hedgehog protein and therapeutic uses thereof. In particular, the technology relates to compositions comprising a hedgehog protein and one or more peptide amphiphiles for use in methods of treating or preventing stress urinary incontinence and/or erectile dysfunction in a subject.
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公开(公告)号：US11419691B2
公开(公告)日：2022-08-23
申请号：US16495028
申请日：2018-06-28
Inventor： Daniel H. Kim , Dong Suk Shin , Taeho Jang , Yongman Park , Jeihan Lee , Hongmin Kim , Kihoon Nam , Seokyung Han
Abstract: The disclosure provides a surgical apparatus comprising: a steerable member that is bendable and comprises a plurality of bending segments with channels therein; and a plurality of bending actuation wires that are arranged to pass through the steerable member and cause the steerable member to bend, the steerable member comprising at least one outwardly opening lumen through which the bending actuation wires pass.
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Patent Agency Ranking
86.发明申请公开(公告)号：US20220249874A1
公开(公告)日：2022-08-11
申请号：US17597508
申请日：2020-07-13
Inventor： Xuejun GU , David PARSONS
IPC: A61N5/10
Abstract: The present disclosures describes a remotely controlled stereotactic radiotherapy system. The system may include a gamma-ray irradiation system for radioablation of a target region of human tissue, the system having an irradiating unit configured to produce a radiation field, and a processor remote from the gamma-ray irradiation system configured to control the dosage and position of the radiation field applied to the target region.
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公开(公告)号：US11377491B2
公开(公告)日：2022-07-05
申请号：US16475223
申请日：2018-01-02
Inventor： X. Charlene Liao , Qiang Liu , Zhiqiang An , Ningyan Zhang , Xun Gui , Chengcheng Zhang , Mi Deng , Jingjing Xie
Abstract: The present disclosure is directed to antibodies binding to LAIR 1 and their treating cancer, inflammation, immune-related diseases or transplantation.
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公开(公告)号：US20220204995A1
公开(公告)日：2022-06-30
申请号：US17458044
申请日：2021-08-26
Applicant: The Board of Trustees of the Leland Stanford Junior University , Board of Regents of the University of Texas System
Inventor： Mark A. Kay , Matthew Porteus , Jenny Barker , Josh Checketts , Richard Voit , Adi Barzel
Abstract: Compositions and methods are provided for integrating one or more genes of interest into cellular DNA without substantially disrupting the expression of the gene at the locus of integration, i.e., the target locus. These compositions and methods are useful in any in vitro or in vivo application in which it is desirable to express a gene of interest in the same spatially and temporally restricted pattern as that of a gene at a target locus while maintaining the expression of the gene at the target locus, for example, to treat disease, in the production of genetically modified organisms in agriculture, in the large scale production of proteins by cells for therapeutic, diagnostic, or research purposes, in the induction of iPS cells for therapeutic, diagnostic, or research purposes, in biological research, etc. Reagents, devices and kits thereof that find use in practicing the subject methods are also provided.
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公开(公告)号：US11365250B2
公开(公告)日：2022-06-21
申请号：US16767152
申请日：2018-11-29
Inventor： Bruce Beutler , Evan Nair-Gill , Xue Zhong , Jinglei Zhang , Pingping Wang
IPC: C07K16/28
Abstract: The present disclosure generally relates to compositions and methods for cancer immunotherapy, as well as hematopoietic recovery following cancer treatment such as chemotherapy or irradiation.
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90.发明授权公开(公告)号：US11326263B2
公开(公告)日：2022-05-10
申请号：US16353183
申请日：2019-03-14
Inventor： Brian Dennis , Krishnan Rajeshwar , Norma Tacconi , Wilaiwan Chanmanee , Homayon Homayoni , Ghazaleh Ghadimkhani
IPC: C25B3/25 , B01J23/72 , B01J37/34 , B01J35/00 , B01J35/02 , H01M14/00 , C25B11/051 , C25B11/057 , C25B11/091 , C25B13/08 , C25B15/08 , H01G9/20 , B01D69/02 , B01D69/12 , B01D71/02 , B01D71/36 , B01D71/80
Abstract: The present disclosure relates to nanocomposites of CuO/Cu2O and continuous flow solar reactors. The nanocomposites can be utilized as a photocatalyst and can be incorporated into photoelectrochemical devices. The described devices, systems, and methods can be used for converting CO2 into one or more alcohols and other small organics with the use of solar energy and electricity. Other embodiments are described.
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