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公开(公告)号：US20170348400A1
公开(公告)日：2017-12-07
申请号：US15400645
申请日：2017-01-06
Inventor： Steven W. Dow , Daniel P. Regan , Amanda Guth , Leah Mitchell
IPC: A61K39/00 , A61K31/4178 , A61K31/404 , A61K31/437 , A61K39/39 , A61K45/06
CPC classification number: A61K39/0005 , A61K31/404 , A61K31/4178 , A61K31/437 , A61K39/39 , A61K45/06 , A61K2039/55511 , A61K2300/00
Abstract: Provided are methods of enhancing an immune response and methods for reducing the recruitment of monocytes to a lymph node by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an antigen. The invention also provides relate methods for amplifying vaccine immunity by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an vaccine. The invention also provides related methods of inhibiting tumor growth and metastasis by administering to an individual with cancer an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an anti-tumor preparation. In addition, related compositions comprising an ARB or a compound of Formula (I) and an antigen, vaccine, or anti-tumor preparation are provided.
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公开(公告)号：US20170281754A1
公开(公告)日：2017-10-05
申请号：US15476723
申请日：2017-03-31
Inventor： Steven Dow , Michael R. Lappin , William H. Wheat , Lyndah Chow , Daniel P. Regan , Thomas J. Anchordoquy
IPC: A61K39/39
Abstract: The disclosed compositions and methods relate to an immunogenic composition that, in certain aspects, comprise cationic liposomes; a mixture of toll like receptor 3 (TLR3) and toll like receptor 9 (TLR9) ligands; and a cellular adhesion agent, and methods of using such compositions. In certain aspects, disclosed compositions are administered to a mammal to induce a non-specific innate immune response at mucosal surfaces. In further aspects, disclosed compositions are administered to a mammal in conjunction with an antigen to enhance the immune response of the mammal to the antigen.
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公开(公告)号：US20170226583A1
公开(公告)日：2017-08-10
申请号：US15121024
申请日：2015-01-21
Inventor： John H. Newman , Rizwan Hamid , John A. Phillips , Joy Cogan , Timothy N. Holt
CPC classification number: C12Q1/6883 , C07K16/28 , C07K2317/34 , C12Q2600/118 , C12Q2600/124 , C12Q2600/156 , G01N33/5308
Abstract: Provided herein are methods and compositions for determining the susceptibility of cattle to High Altitude Pulmonary Hypertension. Also provide are kits and reagents for performing such methods.
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公开(公告)号：US20170212044A1
公开(公告)日：2017-07-27
申请号：US15478982
申请日：2017-04-04
Inventor： Kevin Lear , Timothy Erickson
CPC classification number: G01N21/4133 , G01M11/33 , G01N33/1833 , G01N2021/4166 , G01N2201/0873 , G02B6/028 , G02B6/12004 , G02B6/1221 , G02B6/4291 , G02B27/56 , G02B2006/12123 , G02B2006/12138 , Y02A20/206
Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.
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公开(公告)号：US09692083B2
公开(公告)日：2017-06-27
申请号：US13956320
申请日：2013-07-31
Inventor： Amy L. Prieto , Derek C. Johnson , Matthew T. Rawls
IPC: B05D3/02 , H01M10/056 , H01M10/0525 , H01M10/0585
CPC classification number: H01M10/056 , B05D3/0254 , H01M10/0525 , H01M10/0585
Abstract: Methods are described for forming insulating hybrid organic-inorganic solid electrolytes on conducting electrodes that are active materials in Li-ion batteries by electrochemical deposition, and for forming second conducting electrodes on the solid electrolytes using aqueous slurries, whereby Li-ion battery cells having solid electrolytes are generated. X-ray photoelectron spectroscopy is utilized for determining that the solid electrolytes are defect and pinhole free.
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Patent Agency Ranking
公开(公告)号：US20170176311A1
公开(公告)日：2017-06-22
申请号：US15443620
申请日：2017-02-27
Inventor： Arun K. KOTA , Sanli MOVAFAGHI , Shantanu JATHAR
Abstract: A tunable superomniphobic surface with flower-like TiO2 nanostructures was fabricated into a device with precisely tailored surface energy domains that can sort droplets by surface tension. This apparatus and method for droplet sorting will enable inexpensive and energy-efficient analytical devices for personalized point-of-care diagnostic platforms, lab-on-a-chip systems, fuel sensor applications, biochemical assays and biosensors.
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公开(公告)号：US09618439B2
公开(公告)日：2017-04-11
申请号：US14614192
申请日：2015-02-04
Inventor： John Volckens , Gary Casuccio , Henry P. Lentz , Anthony Marchese , John T. Mastovich , Daniel David Miller-Lionberg , Judith Chun-Hsu Yang
CPC classification number: G01N15/0606 , G01N1/2202 , G01N1/2208 , G01N1/2247 , G01N1/2273 , G01N2001/2276 , G01N2015/0038
Abstract: A thermophoretic sampler includes a sample assembly into which a removable sample cartridge can be inserted. The sample cartridge holds a substrate that, upon insertion, is exposed to a sample chamber. Thermophoresis is induced in the sample chamber, causing nanoparticles to be deposited on the substrate.
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公开(公告)号：US20160222203A1
公开(公告)日：2016-08-04
申请号：US14917795
申请日：2014-09-10
Inventor： Susan P. James , Travis S. Bailey , Ketul C. Popat , David A. Prawel , Jackson T. Lewis , Richard L. Koch
CPC classification number: C08L43/04 , A61F2/16 , A61F2002/1681 , A61L27/48 , C08G77/388 , G02B1/043 , G02C7/049
Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.
Abstract translation: 本文提供了包含聚合物主体的聚合物材料; 和包含糖胺聚糖的客体分子; 其中所述客体分子设置在所述聚合物主体内，并且其中所述客体分子共价键合至至少一个其它客体分子。 在一些实施方案中，聚合物主体包含硅氧烷基聚合物。 在其它实施方案中，糖胺聚糖选自透明质酸及其衍生物。
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公开(公告)号：US20160131580A1
公开(公告)日：2016-05-12
申请号：US14924080
申请日：2015-10-27
Inventor： Kevin L. Lear , David S. Dandy , Matthew D. Stephens , Guangwei Yuan
IPC: G01N21/552 , G01N33/543 , G01N21/41
CPC classification number: G01N21/552 , G01N21/41 , G01N33/54373 , G01N2201/06113 , G01N2201/062 , G01N2201/08
Abstract: A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved.
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公开(公告)号：US09337514B2
公开(公告)日：2016-05-10
申请号：US14059148
申请日：2013-10-21
Inventor： Derek C. Johnson , Amy L. Prieto , Matthew Rawls , Daniel J. Bates , C. Michael Elliott
IPC: H01M10/0585 , H01M10/0525 , H01M2/14 , H01M2/16 , C25D11/00 , G01N27/26
CPC classification number: H01M10/0585 , C09D5/24 , C09D5/4407 , G01N17/02 , G01N27/26 , G01N27/48 , H01M2/145 , H01M2/1653 , H01M10/0525 , Y10T29/49115
Abstract: Methods for reductively polymerizing vinylic based monomers from a solution thereof onto the surface of an electrode material, resulting in thin, electrically insulating solid-polymer electrolyte coatings strongly bound to the surface of the electrode material, are described. The strong bond permits a second electrode to be coated directly onto the solid-polymer electrolyte, thereby incorporating the required components for a Li-ion battery cell. At least one initiator species, which is readily reduced by accepting an electron from the electrode material, is included in electropolymerization deposition solution for permitting the polymerization of vinylic species that would otherwise not electrochemically polymerize without damage to either the electrode material or to the solvents employed.
Abstract translation: 描述了将乙烯基类单体从其溶液还原聚合到电极材料的表面上的方法，导致与电极材料的表面强烈结合的薄的电绝缘的固体聚合物电解质涂层。 强键可以将第二电极直接涂覆在固体聚合物电解质上，从而将所需的组分用于锂离子电池。 至少一种引发剂物质通过从电极材料中接收电子而容易地还原，包括在电聚合沉积溶液中，用于允许不会电化学聚合而不损坏电极材料或所用溶剂的乙烯基物质的聚合 。
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