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    Methods, devices, kits and compositions for detecting roundworm, whipworm, and hookworm
    85.
    发明授权
    Methods, devices, kits and compositions for detecting roundworm, whipworm, and hookworm 有权
    用于检测蛔虫，鞭虫和钩虫的方法，装置，试剂盒和组合物

    公开(公告)号：US08895294B2

    公开(公告)日：2014-11-25

    申请号：US13788532

    申请日：2013-03-07

    Applicant: IDEXX Laboratories, Inc. ,  Divergence, Inc.

    Inventor： David Allen Elsemore ,  Jinming Geng ,  Laurie A. Flynn ,  Michael Crawford

    IPC: G01N33/53 ,  C12M1/34 ,  G01N33/68

    CPC classification number: G01N33/56966 ,  G01N33/5308 ,  G01N33/6893 ,  G01N2333/43526 ,  G01N2333/4353 ,  G01N2469/10

    Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

    Abstract translation: 本文公开了用于检测样品中一种或多种蠕虫类抗原的存在或不存在的方法，装置，试剂盒和组合物。 本发明的方法，装置，试剂盒和组合物可以用于确认来自哺乳动物的粪便样品中蛔虫，鞭虫和/或钩虫的存在或不存在，并且还可以区分一种或多种蠕虫感染。 可以确定哺乳动物中蛔虫，鞭虫和/或钩虫的存在或不存在，例如，为了选择治疗哺乳动物和/或为了确定哺乳动物是否已经除去的目的的最佳过程 的治疗后的感染已经开始。

    Methods for Detecting Symmetrical Dimethylarginine
    86.
    发明申请
    Methods for Detecting Symmetrical Dimethylarginine 有权
    检测对称二甲基精氨酸的方法

    公开(公告)号：US20140242723A1

    公开(公告)日：2014-08-28

    申请号：US14192956

    申请日：2014-02-28

    Applicant: IDEXX Laboratories, Inc.

    Inventor： Murthy V.S.N. Yerramilli ,  Mahalakshmi Yerramilli ,  Michael Atkinson ,  Kwok Kam Yeung

    IPC: G01N33/53 ,  G01N33/543

    CPC classification number: G01N33/53 ,  C07C279/12 ,  C07K16/44 ,  G01N33/54366 ,  G01N33/6812

    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.

    Abstract translation: 检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。 类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。 抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。

    Liposomal analgesic formulation and use
    87.
    发明申请
    Liposomal analgesic formulation and use 有权
    脂质体镇痛剂配方及用途

    公开(公告)号：US20040121987A1

    公开(公告)日：2004-06-24

    申请号：US10327575

    申请日：2002-12-20

    Applicant: IDEXX Laboratories, Inc.

    Inventor： Douglas I. Hepler

    IPC: A61K031/685 ,  A61K031/355 ,  A61K031/195 ,  A61K009/127

    CPC classification number: A61K9/0017 ,  A61K9/127 ,  A61K31/195 ,  A61K31/355 ,  A61K31/685 ,  A61K45/06

    Abstract: A liposome formulation containing about 1% diclofenac is an effective topical anti-inflammatory topical treatment for lameness in horses. More particularly it has been discovered that a formulation containing vitamin E, phospholipid and diclofenac salt such as the sodium or potassium salt is a highly effective topical anti-inflammatory formulation that is particularly effective in treating lameness in horses.

    Abstract translation: 含有约1％双氯芬酸的脂质体制剂是马跛行的有效局部抗炎局部治疗。 更具体地，已经发现，含有维生素E，磷脂和双氯芬酸盐（例如钠盐或钾盐）的制剂是高效的局部抗炎制剂，其特别有效地治疗马的跛足。

    Methods and devices for the detection of pathogenic microorganisms and their antimicrobial susceptibility
    88.
    发明申请
    Methods and devices for the detection of pathogenic microorganisms and their antimicrobial susceptibility 有权
    用于检测病原微生物及其抗菌药物敏感性的方法和装置

    公开(公告)号：US20040005653A1

    公开(公告)日：2004-01-08

    申请号：US10340569

    申请日：2003-01-09

    Applicant: Idexx Laboratories, Inc.

    Inventor： Chun-Ming Chen ,  Charles Carpenter ,  Haoyi Gu ,  Ali Naqui ,  Gary Madsen ,  Thomas O'Connor JR. ,  Katherine Jean Esty

    IPC: C12Q001/04 ,  C12M001/34

    CPC classification number: B01L3/50853 ,  B01L2300/045 ,  B01L2300/0809 ,  C12Q1/04 ,  C12Q1/18

    Abstract: The present invention provides devices and methods for determining the presence or absence of pathogens in a biological sample and for the concurrent determination of the antimicrobial susceptibility of pathogens present. The devices and methods of the present invention are able to make the determinations without pre-selection of target bacteria. Instead, all organisms from the sample are applied to the device. In wells where one or more antimicrobial agents are present only pathogens resistant to the antimicrobial agent grow. This allows the user to determine the presence of target pathogens and concurrently determine the resistance patterns of the organisms without the need to subculture the organisms. The present invention also provides methods of performing a business service of performing the determinations described above, and kits containing the devices and descriptions of the methods.

    Abstract translation: 本发明提供用于确定生物样品中病原体的存在或不存在以及同时测定存在的病原体的抗微生物易感性的装置和方法。 本发明的装置和方法能够在不预先选择目标细菌的情况下进行测定。 相反，将来自样品的所有生物体施加到装置上。 在存在一种或多种抗微生物剂的孔中，只有抗微生物剂抗性的病原体生长。 这允许用户确定目标病原体的存在并且同时确定生物体的抗性模式，而不需要传代培养生物体。 本发明还提供了执行上述确定的业务服务的方法，以及包含所述设备的方法和所述方法的描述的套件的方法。

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