公开(公告)号：US20180008550A1

公开(公告)日：2018-01-11

申请号：US15684086

申请日：2017-08-23

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Kazunori Kataoka ,  Akihiro Kishimura ,  Yasutaka Anraku ,  Akinori Goto

IPC: A61K9/51 ,  C08G69/10 ,  A61K9/10 ,  B01J13/14 ,  C08L77/04 ,  C08G69/40

CPC classification number: A61K9/5146 ,  A61K9/10 ,  A61K9/5123 ,  B01J13/14 ,  C08G69/10 ,  C08G69/40 ,  C08L77/04

Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.

公开(公告)号：US09862942B2

公开(公告)日：2018-01-09

申请号：US14411892

申请日：2013-06-17

Applicant: Japan Science and Technology Agency

Inventor： Tetsuya Yomo ,  Tomoaki Matsuura ,  Haruka Soga ,  Hajime Watanabe ,  Satoshi Fujii

IPC: C12N15/11 ,  C12P21/02 ,  C12N15/10 ,  C12Q1/68

CPC classification number: C12N15/11 ,  C12N15/102 ,  C12N15/1034 ,  C12P21/02 ,  C12Q1/686

Abstract: The objective of the present invention is to improve the efficiency of screening/selection of a membrane protein in molecular evolutionary engineering (for example, an enzyme evolutionary method).The above-described objective is achieved by providing a unilamellar liposome comprising: (a) a DNA comprising a promoter sequence, a translational initiation sequence, and a sequence encoding a membrane protein; (b) an RNA polymerase; (c) a ribonucleotide; and (d) a cell-free protein synthesis system. In one aspect of the present invention, the membrane protein is a transporter, and the unilamellar liposome further comprises (e) a factor that binds to a ligand transported by the membrane protein.

公开(公告)号：US09840540B2

公开(公告)日：2017-12-12

申请号：US14443503

申请日：2013-11-08

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Hideaki Tanaka

IPC: C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K14/47 ,  C12N15/90

CPC classification number: C07K14/47 ,  C07K2319/73 ,  C12N15/902

Abstract: According to an artificial bioparticle characterized in that a leucine zipper is integrated in each N terminal of an MVP constituting a waist of a vault and a method of manufacturing an artificial bioparticle in which a leucine zipper gene is integrated and expressed in a side to be an N terminal of an MVP gene, a novel artificial bioparticle including a vault of which large internal space can effectively be made use of, which can be used as a nanocapsule applicable to a drug delivery system (DDS), and a method of manufacturing the same are provided.

公开(公告)号：US09825232B2

公开(公告)日：2017-11-21

申请号：US14767032

申请日：2013-08-21

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Takanori Fukushima ,  Yoshiaki Shoji ,  Fumitaka Ishiwari ,  Tsuyoshi Sekitani ,  Takao Someya

IPC: H01L51/00 ,  C07C69/712 ,  C07C43/21 ,  C07C43/215 ,  H01L51/05 ,  C07C43/225 ,  C07C69/734 ,  H01L49/02

CPC classification number: H01L51/0055 ,  C07C43/21 ,  C07C43/215 ,  C07C43/225 ,  C07C69/712 ,  C07C69/734 ,  C07C2603/86 ,  C07C2603/90 ,  H01L28/40 ,  H01L51/005 ,  H01L51/0558

Abstract: The present invention provides a high-performance, highly homogeneous, highly stable electronic device by forming an extremely uniform interface between an insulator and an organic semiconductor, as well as an electronic apparatus using the same. The present invention relates to an electronic device which contains, as a component, an organic thin film in which a geometric two-dimensional arrangement is formed regularly by interdigitating skeletal structures of a positive three-pronged shape of triptycene and by adding a first molecule extending out of one plane of a two-dimensional molecular structure of the triptycene skeletal structure. The invention also relates to an electronic apparatus and the like which contains the electronic device in the interior of the electronic apparatus.

公开(公告)号：US09797046B2

公开(公告)日：2017-10-24

申请号：US14396462

申请日：2013-04-25

Applicant: Japan Science and Technology Agency

Inventor： Takatoki Yamamoto ,  Ryuji Hatsuki

IPC: H01L21/302 ,  C23F1/02 ,  H01L21/3213 ,  C09K13/00 ,  C23F1/16 ,  C23F3/03 ,  C23F3/06

CPC classification number: C23F1/02 ,  C09K13/00 ,  C23F1/16 ,  C23F3/03 ,  C23F3/06 ,  H01L21/32134

Abstract: Provided are a method for etching a metal or metal oxide without using a reagent, etc., that affects the environment, a method for smoothing a surface of a metal or metal oxide on an atomic level, and a method for patterning on an atomic level. Etching of a metal or metal oxide, or smoothing of a surface of a metal or metal oxide is possible using ozone water in which only ozone is dissolved. Patterning can also be performed by providing a metal that does not dissolve in the ozone water as a resist on a metal or metal oxide that can be etched by ozone water in which only ozone is dissolved, and etching using the ozone water.

公开(公告)号：US09796677B2

公开(公告)日：2017-10-24

申请号：US15100866

申请日：2014-12-09

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu Kanai ,  Yohei Soma ,  Tadamasa Arai ,  Takushi Araya

IPC: A61K31/44 ,  A61K31/505 ,  C07D213/81 ,  C07D239/28 ,  C07D239/30

CPC classification number: C07D213/81 ,  C07D239/30

Abstract: Provided is a novel compound which has an excellent Aβ aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by the formula (1) or a salt thereof, wherein Z represents CH or N; A and B are the same or different and each represents —CH2—, —O—, —S—, or —NH—; R1 and R2 are the same or different and each represents a branched alkyl group, a branched alkenyl group, an optionally substituted aromatic hydrocarbon group, an optionally substituted aralkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aromatic heterocyclic group; and R3 represents a branched alkyl group, a branched alkenyl group, an optionally substituted cycloalkyl group, or an optionally substituted aralkyl group.

公开(公告)号：US20170290821A1

公开(公告)日：2017-10-12

申请号：US15511930

申请日：2015-09-18

Applicant: Japan Science and Technology Agency

Inventor： Yoshihiro KAWAOKA ,  Tokiko WATANABE ,  Eiryo KAWAKAMI ,  Shinji WATANABE

IPC: A61K31/473 ,  A61K31/519 ,  C12N15/113 ,  C12Q1/68 ,  C12Q1/48

CPC classification number: A61K31/473 ,  A61K31/519 ,  A61K31/713 ,  A61K45/00 ,  C07K14/47 ,  C07K2319/43 ,  C12N9/12 ,  C12N15/09 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2760/16111 ,  C12N2760/16122 ,  C12Q1/485 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Y207/10002 ,  G01N33/50 ,  G01N33/5023 ,  G01N2333/11 ,  G01N2500/10

Abstract: The present invention provides an anti-influenza virus agent that targets biomolecules of host cells including human cells and a method of screening a candidate molecule for the anti-influenza virus agent. That is, the present invention is an anti-influenza virus agent that has an effect of suppressing expression or a function of a gene that encodes a protein having an effect of suppressing incorporation of an influenza virus vRNA or an NP protein into influenza virus-like particles in host cells and the gene is at least one selected from the group including JAK1 gene and the like.

公开(公告)号：US20170235285A1

公开(公告)日：2017-08-17

申请号：US15503245

申请日：2015-09-14

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Shun-ichi Azuma ,  Yuki Minami

IPC: G05B13/04

CPC classification number: G05B13/048 ,  G05B11/36 ,  G05B13/04

Abstract: A predicted value shaping system is provided for calculating a highly accurate control value by shaping of a predicted value. A prediction governor for calculating a control value (v) for controlling a controlled object includes: a result value acquisition unit (22) that acquires a previous target value of the controlled object, that is, a result value (r(t−1)); a predicted value acquisition unit (21) that acquires a predicted value (r (t)) obtained by predicting the target value of the controlled object (12); and a control value calculation unit (23) that calculates a control value (v(t)) for controlling the controlled object (12) by applying the result value (r(t−1)) and the predicted value (r (t)) to a predicted value shaping algorithm (G) to correct the predicted value (r̂(t). The predicted value shaping algorithm (G) uses parameters of a control model (P) of the controlled object (12).

公开(公告)号：US09732249B2

公开(公告)日：2017-08-15

申请号：US14940559

申请日：2015-11-13

Applicant: Japan Science and Technology Agency

Inventor： Atsushi Takahara ,  Motoyasu Kobayashi ,  Hirohmi Watanabe

IPC: C09D129/02 ,  C08F291/04 ,  C08F291/06 ,  C08F291/08 ,  C08F212/14 ,  C09D127/22 ,  C08F291/12 ,  C08F4/40 ,  C08J7/16 ,  C08F283/00 ,  C08G65/44 ,  C09D193/00 ,  C09D4/00 ,  C08F220/34 ,  C09D133/16 ,  C08G61/10 ,  C09D165/02

CPC classification number: C09D129/02 ,  C08F4/40 ,  C08F212/14 ,  C08F220/34 ,  C08F283/00 ,  C08F291/04 ,  C08F291/06 ,  C08F291/08 ,  C08F291/12 ,  C08F2438/01 ,  C08G61/10 ,  C08G65/44 ,  C08G2261/135 ,  C08G2261/1414 ,  C08G2261/312 ,  C08G2261/43 ,  C08G2261/76 ,  C08J7/16 ,  C09D4/00 ,  C09D127/22 ,  C09D133/16 ,  C09D165/02 ,  C09D193/00

Abstract: A novel material is provided herein which is suitable for use in a precursor of a polymer coating material that coats a polymer on a surface of a base material to provide the base material with surface modification and/or functionality assignment. A composite material characterized in that a compound having a polymerization initiation site containing a halogen group is incorporated in a crosslinked structure comprising a catechol derivative or a phenol derivative represented by the following formula (I). In the formula (I), R may be interrupted by an oxygen molecule and represents a hydrocarbon group with 2 to 20 carbons that has at least one double bond site, and A represents a hydrogen atom, a hydroxyl group, or an alkoxy group with 1 to 20 carbons.

公开(公告)号：US20170227538A1

公开(公告)日：2017-08-10

申请号：US15502652

申请日：2015-09-09

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Hiroyuki NOJI

IPC: G01N33/543

CPC classification number: G01N33/54393 ,  C12Q1/68 ,  G01N33/543

Abstract: Provided is a method to detect a target molecule, including a complex formation step of reacting a target molecule, a carrier modified with a first antibody which specifically binds to the target molecule, and two or more second antibodies which specifically bind to the target molecule, and are labeled with enzymes having a substrate cleaving activity and mutually different substrate specificities, to form a complex consisting of the first antibody, the target molecule and the second antibodies, on the carrier; and a detection step of reacting two or more substrates having cleavage sites by the enzymes, a fluorescent substance bound to one terminal side of each of the cleavage sites and a quencher bound to another terminal side thereof, wherein the fluorescent substances are mutually different in fluorescence wavelength, and the complex, to detect fluorescence emitted from the fluorescent substances.