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    Reducing optical interference in a fluidic device
    87.
    发明授权
    Reducing optical interference in a fluidic device 有权

    公开(公告)号：US11442061B2

    公开(公告)日：2022-09-13

    申请号：US15951769

    申请日：2018-04-12

    Applicant: Labrador Diagnostics LLC

    Inventor： Ian Gibbons ,  Michael O'Connell

    IPC: G01N33/53 ,  B01L3/00 ,  G01N33/536

    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces interference with an optical signal which is indicative of the presence of an analyte in a bodily sample.

    DEVICES, METHODS AND SYSTEMS FOR REDUCING SAMPLE VOLUME
    89.
    发明申请
    DEVICES, METHODS AND SYSTEMS FOR REDUCING SAMPLE VOLUME 有权

    公开(公告)号：US20220258154A1

    公开(公告)日：2022-08-18

    申请号：US17514466

    申请日：2021-10-29

    Applicant: Labrador Diagnostics LLC

    Inventor： Xinwei Sam Gong ,  Daniel L. Young ,  William Westrick

    IPC: B01L3/00 ,  G01N35/00 ,  G01N21/64 ,  G01N21/27 ,  G01N21/03

    Abstract: Devices, methods and systems are provided for reducing the sample volume required for analysis. Inserts placed within a sample container, and substitute sample containers having smaller volume sample chambers are provided. Methods are provided for detection and quantification of target substances in reduced volume samples. Methods include placing a small-volume of sample in a small-volume insert. Methods include diluting a small-volume sample, and placing the diluted sample in a small-volume insert. Methods include reducing the volume of sample, and: increasing illumination; increasing dye concentration or amount; increasing the amount of an enzyme substrate; increasing the amounts, concentration, or labeling of antibodies for detection; increasing optical detector sensitivity; increasing the path length of light passing through the sample; decreasing the separation between sample and detector; altering the wavelength, or polarization, or number of wavelengths, passing through the sample; increasing electronic amplification of electrical signals; altering assay temperature; and other alterations.

    METHODS AND DEVICES FOR IMPROVED SIGNAL DETECTION FROM BIOLOGICAL SAMPLES
    90.
    发明申请
    METHODS AND DEVICES FOR IMPROVED SIGNAL DETECTION FROM BIOLOGICAL SAMPLES 有权

    公开(公告)号：US20220228976A1

    公开(公告)日：2022-07-21

    申请号：US17533510

    申请日：2021-11-23

    Applicant: Labrador Diagnostics LLC

    Inventor： Toan Huynh

    IPC: G01N21/33 ,  G01N33/49

    Abstract: Methods and devices are provided to provide clean signals even in the presence of spectral interference. At least some of these methods can be applied for cases when interfering signals are to be accounted for. These cases include, but are not limited to, hemolysis detection, icterus detection, and assays. They can be implemented in with data collected with spectrophotometers, instruments that can collect absorbance values at the few wavelengths of interest, and, in the case of the method based on background subtraction, simple imaging setups with only two filters (such as but not limited to narrow-band and wide-band) per absorption peak of interest.

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