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81.
公开(公告)号:US20230295280A1
公开(公告)日:2023-09-21
申请号:US17267672
申请日:2019-10-11
Applicant: Tokyo University of Science Foundation
Inventor: Yoichiro IWAKURA , Rikio YABE
CPC classification number: C07K16/18 , A61P19/02 , C07K14/78 , G01N33/68 , G01N2333/78
Abstract: Provided are: a maturation suppressor for dendritic cells, said maturation suppressor inhibiting the binding of TARM1 protein to collagen protein to thereby suppress the maturation of dendritic cells; a maturation suppression method for dendritic cells, said method comprising using the maturation suppressor; a pharmaceutical composition containing the maturation suppressor as an active ingredient; a method for screening a maturation suppressor for dendritic cells; and a method for screening a therapeutic component for a disease mediated by dendritic cells.
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公开(公告)号:US20230115206A1
公开(公告)日:2023-04-13
申请号:US17960314
申请日:2022-10-05
Inventor: Tomohito NAKAMORI , Keisuke MATSUYAMA , Takuya KUROSAKA , Hiroshi GOTODA , Natsumi KIKUTA
Abstract: A sign detection device is provided with a plurality of sensors, a data acquisition unit, a calculation unit, and a detection unit. The plurality of sensors are respectively disposed at a plurality of positions of a detection target to measure a physical parameter at each positions.
The data acquisition unit is configured to acquire time-series change data of the physical parameters from the plurality of sensors. The calculation unit is configured to calculate dynamic network information representing a time change of a complex network structure including a parameter indicating a correlation between the physical parameters at any two positions of the plurality of positions, on the basis of the time-series change data. The detection unit is configured to detect a sign of sudden change vibration of the detection target, on the basis of the dynamic network information.-
公开(公告)号:US20230070704A1
公开(公告)日:2023-03-09
申请号:US17799750
申请日:2021-02-15
Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION
Inventor: Satoshi Iriyama , Maki Kihara
Abstract: In an encryption authentication system, a service server transmits the third encryption information to a user terminal, in a case where the service server receives a request from the user terminal. The user terminal calculates fourth encryption information and transmits the fourth encryption information to an encryption server. The encryption server and the calculation server cooperate with each other to calculate encryption information as a collation target and transmit the encryption information to the service server. The service server obtains a coincidence degree between the first plaintext information included in the encryption information as the collation target and the second plaintext information, by a collation function using a third encryption key and a second encryption key used to calculate registration encryption information, and transmits an authentication result corresponding to the coincidence degree to the user terminal.
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公开(公告)号:US20220384116A1
公开(公告)日:2022-12-01
申请号:US17886548
申请日:2022-08-12
Applicant: DENSO CORPORATION , TOKYO UNIVERSITY OF SCIENCE FOUNDATION
Inventor: YOSHIHIRO KOZAWA , NORIYUKI MATSUSHITA , KAZUHIKO KANO , YUMI TANAKA , HIROKI OTSUKA , YUSUKE EDANO
Abstract: A power generator includes a power generating unit and at least one of a power storage unit or an output unit that is electrically connected to the power generating unit. The power generating unit includes an electret having a first charged surface and a second charged surface that are charged with opposite polarities, a first electrode formed on the first charged surface, and a second electrode formed on the second charged surface. The electret is formed by polarizing an electret material that includes an inorganic dielectric having a bandgap energy of 4 eV or more. At least one of the first electrode or the second electrode are partially disposed on the corresponding charged surface such that at least one of the first charged surface or the second charged surface has a portion as a current collecting surface exposed outward.
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85.
公开(公告)号:US20220313647A1
公开(公告)日:2022-10-06
申请号:US17629457
申请日:2020-09-25
Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION
Inventor: Akiyoshi SAITOH , Yuya TERASHIMA , Kouji MATSUSHIMA , Yoshitake SANO
IPC: A61K31/27 , A61K31/145 , A61P25/24 , A61P25/28
Abstract: Disclosed is a novel measure that is effective in therapy etc. of psychiatric or neurological disorders or symptoms, such as anxiety or depressive disorders, and is unlikely to cause problems such as dependence and adverse effects and is highly safe. The present invention provides an agent for treating, preventing, or ameliorating psychiatric or neurological disorders or symptoms, wherein the agent contains any of the followings as an active ingredient: (1) disulfiram, (2) a metal complex of diethyldithiocarbamate, (3) a disulfide capable of generating diethyldithiocarbamate in the body, (4) a pharmaceutically acceptable salt of (1), (2), or (3), and (5) a solvate of (1), (2), (3), or (4).
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公开(公告)号:US20220313131A1
公开(公告)日:2022-10-06
申请号:US17642168
申请日:2020-09-10
Applicant: Lightnix, Inc. , Tokyo University of Science Foundation
Inventor: Noriyuki KOBAYASHI , Makiya NISHIKAWA , Kosuke KUSAMORI , Asuka SHIMOMURA , Moeka NISHIMURA
Abstract: A device which, in a shallow region including the epidermal layer or the dermal layer, can administer a target even in extremely small amounts. This includes a puncture needle which, in a flat puncture unit for puncturing the shallow region, has a groove and a through-hole which constitute a recess that extends through part of or the entire thickness of the puncture unit; and a casing which houses the puncture needle so as to allow the puncture needle to advance. By part or all of a flow agent containing the drug being arranged in the groove and the through-hole, the drug is positioned with respect to the puncture unit. The device is designed such that a flow agent in the amount of 10-1000 nL is dosed in the shallow region per puncture.
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87.
公开(公告)号:US20220306593A1
公开(公告)日:2022-09-29
申请号:US17633365
申请日:2020-08-25
Applicant: Tokyo University of Science Foundation
Inventor: Hideyo TAKAHASHI , Kosho MAKINO , Kaya GU , Yuki TANAKA
IPC: C07D279/34
Abstract: An enantiomer preparation method in which one enantiomer of a sulfoxide compound is selectively prepared, the sulfoxide compound having a sulfur atom of a sulfoxide group as an asymmetric center, the method including a step A for optically resolving an enantiomer mixture of a sulfoxide compound into one enantiomer and the other enantiomer; a step B for irradiating with light the other enantiomer obtained in step A or step C to racemize the enantiomer; and step C for optically resolving the enantiomer mixture of the sulfoxide compound obtained in step B into one enantiomer and the other enantiomer. A system for preparing an enantiomer which is used in the enantiomer preparation method.
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公开(公告)号:US11450445B2
公开(公告)日:2022-09-20
申请号:US16895704
申请日:2020-06-08
Inventor: Koji Arimitsu , Makoto Wakabayashi
IPC: G03F7/16 , G03F7/09 , G03F7/004 , G03F7/20 , G03F7/34 , H01B1/12 , H01B13/00 , H01L51/00 , C03C17/28 , H01B5/14
Abstract: A method for manufacturing an electroconductive pattern 40, provided with: a lamination step for laminating an acid generation film 10 containing an acid proliferation agent and a photoacid generator on a polymer film 20 containing an electroconductive polymer formed on a substrate 21; a masking step for masking the top of the acid generation film 10; a light irradiation step for irradiating the laminate from the acid-generation-film 10 side; a doping step for doping the electroconductive polymer with an acid generated and proliferated in the acid generation film 10 by the light irradiation; and a releasing step for releasing the acid generation film 10 from the polymer film 20. This method makes it possible to provide an electroconductive film and a method for manufacturing an electroconductive pattern in which photoacid generation and acid proliferation effects are utilized.
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公开(公告)号:US11145863B2
公开(公告)日:2021-10-12
申请号:US16463789
申请日:2017-11-20
Applicant: Tokyo University of Science Foundation
Inventor: Shinichi Komaba , Kei Kubota , Kuniko Chihara , Akihiro Katogi
IPC: H01M4/58 , C01G31/00 , H01M10/054 , C01B25/455 , C01B25/45 , H01M4/02
Abstract: Provided is the positive electrode active material for a potassium ion battery according to the embodiment comprises a compound represented by Formula (1), in which M represents at least one element selected from the group consisting of V, Fe, Co, Ni, and Mn, and x represents a number from 0 to 1; and is a positive electrode for a potassium ion battery comprising the positive electrode active material for a potassium ion battery according to the embodiment, or a potassium ion battery comprising the positive electrode for a potassium ion battery. KMOxPO4F1-x [Formula (1)].
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公开(公告)号:US10976306B2
公开(公告)日:2021-04-13
申请号:US15736089
申请日:2016-06-15
Applicant: Tokyo University of Science Foundation
Inventor: Etsuko Miyamoto , Masaaki Ozawa
IPC: G01N33/50 , C07D239/49 , C07K5/00 , C12Q1/02 , A61K38/00 , C12N9/00 , C07K14/47 , C12N9/76 , C12P21/06
Abstract: Provided are: a protein degradation inducing tag which is a molecule that has affinity with proteases and does not inhibit degradation of a protein by proteases; a protein degradation inducing molecule that is a conjugate of at least one protein degradation inducing tag and at least one protein binding molecule that binds to a protein; and a usage of those.
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