公开(公告)号：US20220313647A1

公开(公告)日：2022-10-06

申请号：US17629457

申请日：2020-09-25

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Akiyoshi SAITOH ,  Yuya TERASHIMA ,  Kouji MATSUSHIMA ,  Yoshitake SANO

IPC: A61K31/27 ,  A61K31/145 ,  A61P25/24 ,  A61P25/28

Abstract: Disclosed is a novel measure that is effective in therapy etc. of psychiatric or neurological disorders or symptoms, such as anxiety or depressive disorders, and is unlikely to cause problems such as dependence and adverse effects and is highly safe. The present invention provides an agent for treating, preventing, or ameliorating psychiatric or neurological disorders or symptoms, wherein the agent contains any of the followings as an active ingredient: (1) disulfiram, (2) a metal complex of diethyldithiocarbamate, (3) a disulfide capable of generating diethyldithiocarbamate in the body, (4) a pharmaceutically acceptable salt of (1), (2), or (3), and (5) a solvate of (1), (2), (3), or (4).

公开(公告)号：US20230220022A1

公开(公告)日：2023-07-13

申请号：US18092737

申请日：2023-01-03

Applicant: The University of Tokyo ,  ONO PHARMACEUTICAL CO., LTD. ,  TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Kouji MATSUSHIMA ,  Satoshi UEHA ,  Shungo DESHIMARU ,  Chang-Yu CHEN ,  Shoji YOKOCHI ,  Yoshiro ISHIWATA ,  Shiro SHIBAYAMA

IPC: C07K14/47 ,  A61P35/00 ,  A61K38/00

CPC classification number: C07K14/47 ,  A61P35/00 ,  A61K38/00

Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.

公开(公告)号：US20220356462A1

公开(公告)日：2022-11-10

申请号：US17625918

申请日：2020-07-10

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Kouji MATSUSHIMA ,  Satoshi UEHA ,  Shigeyuki SHICHINO ,  Satoru ITO ,  Hiroyasu AOKI

IPC: C12N15/10 ,  C12Q1/6874

Abstract: A nucleic acid amplification method using a solid-phase carrier according to the present invention comprises: capturing a target nucleic acid comprising mRNA on a solid-phase carrier; carrying out complementary-strand synthesis on the solid phase; carrying out exonuclease treatment to degrade and remove unreacted target- capturing nucleic acid on the solid phase; and then carrying out mRNA degradation and homopolymer addition by TdT reaction in the presence of a chain-terminating nucleotide triphosphate. According to the method of the present invention, cDNA can be stably and highly efficiently amplified even from a small amount of sample even in cases where the ratio of the amount of enzyme to the DNA substrate on the solid phase is excessive, where the reaction time is excessive, and/or where reagents show lot-to-lot variation. Further, the amplification method of the present invention can broaden the range of applications of techniques in which analysis using a specific-binding molecule labeled with an oligonucleic acid such as a DNA-labeled antibody and analysis of transcripts are carried out simultaneously.