公开(公告)号：US20240156796A1

公开(公告)日：2024-05-16

申请号：US18278246

申请日：2022-02-25

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  NIPPON CHEMIPHAR CO., LTD.

Inventor： Akiyoshi SAITOH ,  Daisuke YAMADA ,  Eriko NAKATA

IPC: A61K31/444 ,  A61K31/439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61P25/22

CPC classification number: A61K31/444 ,  A61K31/439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61P25/22

Abstract: The present invention provides a pharmaceutical composition for the treatment or prevention of stress-related disorders, stress-induced anxiety disorders, or stress-related disorders or anxiety disorders associated with depression, the composition containing a selective δ-opioid receptor agonist as an active component, wherein the selective δ-opioid receptor agonist preferably also has a μ-opioid receptor antagonist action and a κ-opioid receptor antagonist action.

公开(公告)号：US20220313647A1

公开(公告)日：2022-10-06

申请号：US17629457

申请日：2020-09-25

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Akiyoshi SAITOH ,  Yuya TERASHIMA ,  Kouji MATSUSHIMA ,  Yoshitake SANO

IPC: A61K31/27 ,  A61K31/145 ,  A61P25/24 ,  A61P25/28

Abstract: Disclosed is a novel measure that is effective in therapy etc. of psychiatric or neurological disorders or symptoms, such as anxiety or depressive disorders, and is unlikely to cause problems such as dependence and adverse effects and is highly safe. The present invention provides an agent for treating, preventing, or ameliorating psychiatric or neurological disorders or symptoms, wherein the agent contains any of the followings as an active ingredient: (1) disulfiram, (2) a metal complex of diethyldithiocarbamate, (3) a disulfide capable of generating diethyldithiocarbamate in the body, (4) a pharmaceutically acceptable salt of (1), (2), or (3), and (5) a solvate of (1), (2), (3), or (4).