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    Bioabsorbable, biobeneficial polyester polymers for stent coatings
    81.
    发明申请
    Bioabsorbable, biobeneficial polyester polymers for stent coatings 有权
    用于支架涂层的生物可吸收，生物有益的聚酯聚合物

    公开(公告)号：US20070100123A1

    公开(公告)日：2007-05-03

    申请号：US11643331

    申请日：2006-12-20

    Applicant: Syed Hossainy ,  Stephen Pacetti

    Inventor： Syed Hossainy ,  Stephen Pacetti

    IPC: C08G63/02

    CPC classification number: A61L31/06 ,  A61L27/18 ,  C08G63/20 ,  C08G63/668 ,  C08G63/6854 ,  C08G63/6886 ,  C08L67/02 ,  C08L67/025 ,  C08L67/04 ,  C08L69/00 ,  C08L73/02 ,  C08L2666/20 ,  C08L2666/18

    Abstract: This disclosure covers polymers, some of which are useful in medical device applications. Some of these medical devices are implantable within a mammalian body, such as in a body lumen. The copolymers comprise at least one alcoholic moiety derived from a diol, triol, or polyol. Additionally, the copolymers comprise an acidic moiety, derived from a polycarboxylic acid, and a biobeneficial moiety. Some of these copolymers are biodegradable or bioerodable. Medical devices comprising these polymers and methods of making these polymers are within the scope of this disclosure.

    Abstract translation: 本公开内容涵盖聚合物，其中一些在医疗器械应用中是有用的。 这些医疗装置中的一些可植入哺乳动物体内，例如在体腔中。 共聚物包含至少一种衍生自二醇，三醇或多元醇的醇部分。 另外，共聚物包含衍生自多元羧酸的酸性部分和生物有益部分。 这些共聚物中的一些是可生物降解的或可生物侵蚀的。 包含这些聚合物的医疗装置和制备这些聚合物的方法在本公开的范围内。

    Polymeric coating for reducing the rate of release of a therapeutic substance from a stent
    83.
    发明申请
    Polymeric coating for reducing the rate of release of a therapeutic substance from a stent 审中-公开
    用于降低治疗物质从支架释放速率的聚合物涂层

    公开(公告)号：US20070016284A1

    公开(公告)日：2007-01-18

    申请号：US11526126

    申请日：2006-09-22

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: A61F2/06

    CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/08

    Abstract: A stent for delivery of a therapeutic agent is disclosed. The stent includes a polymer coating for reducing the rate of release of the therapeutic agent. The polymer has a crystalline structure wherein the polymer is capable of significantly maintaining the crystalline lattice structure while the therapeutic agent is released from the stent such that the aqueous environment to which the stent is exposed subsequent to the implantation of the stent does not significantly convert the crystalline lattice structure of the polymer to an amorphous structure.

    Abstract translation: 公开了用于递送治疗剂的支架。 支架包括用于降低治疗剂释放速率的聚合物涂层。 聚合物具有结晶结构，其中聚合物能够显着地保持结晶晶格结构，同时治疗剂从支架中释放，使得在支架植入之后支架暴露的水性环境不会显着地转化为 聚合物的晶格结构为非结晶结构。

    Amorphous poly(D,L-lactide) coating
    85.
    发明申请
    Amorphous poly(D,L-lactide) coating 有权
    无定形聚（D，L-丙交酯）涂层

    公开(公告)号：US20060246108A1

    公开(公告)日：2006-11-02

    申请号：US11117813

    申请日：2005-04-29

    Applicant: Stephen Pacetti ,  Syed Hossainy ,  David Gale

    Inventor： Stephen Pacetti ,  Syed Hossainy ,  David Gale

    IPC: A61F2/00 ,  C08L67/00

    CPC classification number: A61L31/10 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  C08L101/00 ,  C09D167/04 ,  C08L67/04 ,  C08L2666/02

    Abstract: Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    Abstract translation: 提供由包含由诸如内消旋-D，L-丙交酯的原料形成的无定形聚（D，L-丙交酯）的材料形成或涂覆的可植入装置。 可植入装置可用于治疗，缓解，预防或抑制动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，卵圆孔未闭，跛行， 静脉和人造移植物的吻合增殖，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

    Polymers of fluorinated monomers and hydrocarbon monomers
    86.
    发明申请
    Polymers of fluorinated monomers and hydrocarbon monomers 有权

    公开(公告)号：US20060134165A1

    公开(公告)日：2006-06-22

    申请号：US11021775

    申请日：2004-12-22

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: C08F214/18 ,  A61F13/00

    CPC classification number: A61L31/048 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  C08F214/18 ,  C08F295/00 ,  C09D127/16 ,  C08L27/12 ,  A61K31/10

    Abstract: A polymer of fluorinated monomers and hydrocarbon monomers is provided. It is also provided a polymer blend that contains a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. The polymer or polymer blend described herein and optionally a bioactive agent can form an implantable device such as a stent or a coating on an implantable device such as a drug-delivery stent, which can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    Blends of poly(ester amide) polymers
    88.
    发明申请
    Blends of poly(ester amide) polymers 有权
    聚（酯酰胺）聚合物的共混物

    公开(公告)号：US20060074191A1

    公开(公告)日：2006-04-06

    申请号：US10960381

    申请日：2004-10-06

    Applicant: Jessica DesNoyer ,  Stephen Pacetti ,  Lothar Kleiner

    Inventor： Jessica DesNoyer ,  Stephen Pacetti ,  Lothar Kleiner

    IPC: C08L77/00 ,  C08G69/48

    CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  C08L77/12 ,  C08L2666/14

    Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    Abstract translation: 本文提供了聚（酯酰胺）（PEA）聚合物共混物和含有PEA聚合物共混物的聚合物涂层。 PEA聚合物共混物在聚（酯酰胺苄酯）（PEA-Bz）或T N g N T T上方具有T N' 的聚（酯酰胺TEMPO）。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

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