公开(公告)号：US20180306759A1

公开(公告)日：2018-10-25

申请号：US16016866

申请日：2018-06-25

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER

IPC: G01N30/20 ,  G01N30/32 ,  G01N35/10 ,  G01N30/24 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/32 ,  G01N35/1097 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/207

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

公开(公告)号：US20180246070A1

公开(公告)日：2018-08-30

申请号：US15903166

申请日：2018-02-23

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： Lauryn E. DeGreeff ,  Christopher J. Katilie

IPC: G01N30/12 ,  G01N30/20 ,  G01N30/30

CPC classification number: G01N30/12 ,  C07C69/96 ,  G01N30/06 ,  G01N30/20 ,  G01N30/30 ,  G01N2030/025 ,  G01N2030/042 ,  G01N2030/067 ,  G01N2030/126 ,  G01N2030/201

Abstract: A method of detecting an analyte by: providing a derivatizing agent that is reactive with the analyte; delivering the derivatizing agent into a chamber; delivering a sample of a gas suspected of containing the analyte into the chamber before or after delivering the derivatizing agent, while the chamber is maintained at a temperature that retains the derivatizing agent and any analyte and that allows reaction between the derivatizing agent and any analyte in the chamber to form a derivatized analyte; warming the chamber to cause evaporation of any derivatized analyte; and delivering the derivatized analyte in the chamber into a gas chromatograph column.

公开(公告)号：US20180224006A1

公开(公告)日：2018-08-09

申请号：US15877679

申请日：2018-01-23

Applicant: Micromeritics Instrument Corporation

Inventor： Graham Robert Killip

IPC: F16K11/074 ,  G01N30/20 ,  G01N30/38

CPC classification number: F16K11/0743 ,  G01N30/20 ,  G01N30/34 ,  G01N30/38 ,  G01N2030/201 ,  G01N2030/347 ,  Y10T137/86823 ,  Y10T137/87249 ,  G01N2030/202

Abstract: A blend valve assembly including a plurality of ports, a stator having at least one fluid flow path defined therein that extends between at least one port of the plurality of ports in communication with the primary fluid media and at least one port of the plurality of ports in communication with an intake of a testing device, and a rotor comprising at least one fluid flow path defined therein. The rotor is movable between a series of positions such that the blend valve assembly is operable to provide the intake of the testing device with only the primary fluid media and to provide the intake of the testing device with a blend of the primary fluid media and the secondary fluid media.

公开(公告)号：US20170343518A1

公开(公告)日：2017-11-30

申请号：US15608903

申请日：2017-05-30

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann

IPC: G01N30/06 ,  G01N30/20 ,  G01N30/22

CPC classification number: G01N30/06 ,  F16K11/074 ,  G01N30/20 ,  G01N30/22 ,  G01N30/32 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

公开(公告)号：US09816971B2

公开(公告)日：2017-11-14

申请号：US14824440

申请日：2015-08-12

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Sylvain Cormier

IPC: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202

Abstract: Described are a method and a system for injecting a sample into a flow of a liquid chromatography system. The method includes combining a flow of a sample and a flow of a mobile phase to create a diluted sample in the system flow. The volumetric flow rate of the sample is controlled to be at a value that yields a desired dilution ratio for the diluted sample. The particular value at which the volumetric flow rate is maintained can be determined from the desired value of the dilution ratio and the volumetric flow rate of the mobile phase. System embodiments include a syringe that can be used to provide a sample solution at a controllable volumetric flow rate for combination with a high pressure mobile phase.

公开(公告)号：US20170176400A1

公开(公告)日：2017-06-22

申请号：US15129543

申请日：2014-10-22

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Sang-Won LEE ,  Hangyeore LEE

IPC: G01N30/46 ,  G01N30/20

CPC classification number: G01N30/468 ,  B01D15/1864 ,  G01N30/08 ,  G01N30/20 ,  G01N2030/009 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: A dual online liquid chromatography device according to an embodiment of the present invention comprises: a first pump for injecting a first solvent or a mixed solution containing the first solvent and a second solvent; a second pump for injecting the first solvent or the mixed solution containing the first and second solvents; a specimen intake valve connected to the first pump and a specimen injector for injecting a specimen; a column selection valve connected to the second pump and the specimen intake valve; and a dual column valve including a plurality of ports, one side of which is connected to the column selection valve and an opposite side of which is connected to a first column and a second column.

公开(公告)号：US09649634B2

公开(公告)日：2017-05-16

申请号：US14993540

申请日：2016-01-12

Applicant: SHIMADZU CORPORATION

Inventor： Tomoyuki Yamazaki

IPC: B01L99/00 ,  B01L3/00 ,  G01N30/18 ,  G01N30/20

CPC classification number: B01L3/563 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2200/0689 ,  B01L2300/0832 ,  G01N30/18 ,  G01N2030/201 ,  G01N2030/202

Abstract: Provided is a mechanism for connecting columns and needles, including: a base member 60 on which needles 61a and 61b with their tips directed upward are provided; and a column rack 10 having column holders for holding columns 10a and 10b in an upright position while allowing all upward shift of the columns, with an opening provided below each column holder. With the needles 61a and 61b positioned directly below the openings, the base member 60 is elevated until its upper surface comes in contact with the bottom of the column rack 10, whereby the needles 61a and 61b are inserted through the openings into the columns 20a and 20b. When the base member 60 is in contact with the column rack 10, the columns 20a and 20b are pushed by the needles 61a and 61b to a higher position within the column rack 10 than their original position.

公开(公告)号：US09611942B2

公开(公告)日：2017-04-04

申请号：US14002401

申请日：2012-03-01

Applicant: Michael Schubert ,  Reinhard Busch ,  Michael Nader

Inventor： Michael Schubert ,  Reinhard Busch ,  Michael Nader

IPC: G01N30/20 ,  F16K11/00 ,  F16K11/074 ,  G01N35/10 ,  G01N30/26

CPC classification number: F16K11/00 ,  F16K11/0743 ,  G01N30/20 ,  G01N30/26 ,  G01N35/1097 ,  G01N2030/201 ,  G01N2030/202 ,  Y10T137/86493

Abstract: The invention relates to a valve, in particular a sample injection valve, for a device (1) for synthesizing, analyzing, and/or separating, comprising at least three liquid connections (3′, 4′, 5′, 6′, 7′, 7″), a housing (8) as a valve part, and a valve body (9) as another valve part for selectively connecting the liquid connections (3′, 4′, 5′, 6′, 7′, 7″) by means of at least one flow channel (10, 11, 12) bounded at least partially by sealing surfaces (10′, 11′, 12′) between the housing (8) and the valve body (9), wherein the housing (8) and/or the valve body (9) are supported in such a way as to be movable relative to each other. In order to create a one-way valve, at least one valve part (8 or 9) adjacent to the sealing surface (10′, 11′, 12′) and made of a plastic material can be plastically deformed according to a relative position (9′), in particular of the valve body (9), in order to be able to withstand the elevated pressure loads in the flow channel (10, 11, 12) in a liquid-tight manner in the relative position (9′), in particular of the valve body (9).

公开(公告)号：US08944102B1

公开(公告)日：2015-02-03

申请号：US13414210

申请日：2012-03-07

Applicant: Daniel R. Wiederin ,  Nathan Saetveit

Inventor： Daniel R. Wiederin ,  Nathan Saetveit

IPC: F16K11/074 ,  G01N1/00 ,  G01N30/20

CPC classification number: F16K11/0743 ,  G01N2030/201 ,  G01N2030/202 ,  H01J49/0495 ,  H01J49/105 ,  Y10T137/86863

Abstract: Valve assemblies are described that provide bursts of gas between fluids to furnish separation between the fluids. A valve assembly includes a first valve member having ports configured to connect to an external loop, an output, and a vent, and ports configured to receive a first fluid, a second fluid, and a pressurized gas. The valve assembly further includes a second valve member coupled adjacent the first valve member having channels configured to connect the external loop to the second fluid for charging the external loop with the second fluid, and to connect the external loop to the output for supplying the second fluid from the external loop to the output. The second valve member also has one or more channels for receiving a burst of the pressurized gas via a port of the first valve member and supplying the pressurized gas to the output and/or to the external loop.

Abstract translation: 描述了在流体之间提供气体脉冲以提供流体之间的分离的阀组件。 阀组件包括具有构造成连接到外部回路，输出端口和通气口的端口的第一阀构件以及被配置为接收第一流体，第二流体和加压气体的端口。 所述阀组件还包括与所述第一阀构件相邻的第二阀构件，所述第二阀构件具有被配置为将所述外部回路连接到所述第二流体的通道，以使所述外部回路与所述第二流体充电，以及将所述外部回路连接到所述输出端， 流体从外部回路输出。 第二阀构件还具有一个或多个通道，用于经由第一阀构件的端口接收加压气体的爆裂并将加压气体供应到输出端和/或外部回路。

公开(公告)号：US20140338431A1

公开(公告)日：2014-11-20

申请号：US14454563

申请日：2014-08-07

Applicant: Dionex Softron GmbH

Inventor： Hermann Hochgraeber

IPC: G01N30/20 ,  G01N35/10 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/32 ,  G01N35/1097 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/207

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

Abstract translation: 使用具有废物口，两个样品回路端口和两个高压端口的注射阀进行液相色谱法的样品注射方法。 一个高压端口可以连接到泵，另一个高压端口可以连接到色谱柱。 样品回路连接到一端的一个样品回路端口和另一端的样品输送装置的泵体积。 样品回路的一部分可以分开，以便于在样品回路中接收样品流体。 控制单元控制喷射阀和样品输送装置。 样品注射器允许将样品装载到样品环中，然后在将样品注入色谱柱之前加压至操作压力。 样品回路也可以与操作压力隔离，以便于循环的减压。