公开(公告)号：US20140127701A1

公开(公告)日：2014-05-08

申请号：US14110649

申请日：2012-04-06

Applicant: Mauro Aguanno ,  Damian Curtin ,  Damien King

Inventor： Mauro Aguanno ,  Damian Curtin ,  Damien King

IPC: G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/253 ,  G01N21/55 ,  G01N21/6452 ,  G01N21/6486 ,  G01N2201/0631 ,  G01N2201/0638

Abstract: Systems and methods are used to detect spectral and spatial information in a continuous flow PCR system. An incident beam of electromagnetic radiation is emitted using a laser. The incident beam is received from the laser and incident beam is transformed into an incident line of electromagnetic radiation using a line generator. The incident line is received from the line generator using a tube array that includes one or more transparent tubes in fluid communication with one or more micro-channels. Reflected electromagnetic radiation is received from the tube array and the reflected electromagnetic radiation is focused using an imaging lens. The focused reflected electromagnetic radiation is received from the imaging lens and a spectral intensity is detected from the focused reflected electromagnetic radiation using a spectrograph. The focused reflected electromagnetic radiation is received from the imaging lens and a location of the spectral intensity is detected using an imager.

Abstract translation: 系统和方法用于检测连续流PCR系统中的光谱和空间信息。 使用激光发射入射的电磁辐射光束。 从激光器接收入射光束，并且使用线发生器将入射光束变换成电磁辐射的入射线。 使用管阵列从线发生器接收入射线，该管阵列包括与一个或多个微通道流体连通的一个或多个透明管。 从管阵列接收反射的电磁辐射，并且使用成像透镜聚焦反射的电磁辐射。 从成像透镜接收聚焦的反射电磁辐射，并且使用光谱仪从聚焦的反射电磁辐射检测光谱强度。 从成像透镜接收聚焦的反射电磁辐射，并使用成像器检测光谱强度的位置。

公开(公告)号：US20130267799A1

公开(公告)日：2013-10-10

申请号：US13441467

申请日：2012-04-06

Applicant: Hannu Harjunmaa ,  Stevan Kun

Inventor： Hannu Harjunmaa ,  Stevan Kun

IPC: A61B5/1455 ,  A61B6/00

CPC classification number: A61B5/14532 ,  A61B5/0051 ,  A61B5/1455 ,  A61B5/6816 ,  A61B5/6826 ,  A61B2560/0431 ,  A61B2562/0233 ,  A61B2562/146 ,  F04C2270/041 ,  G01N21/1717 ,  G01N21/314 ,  G01N21/359 ,  G01N21/474 ,  G01N21/49 ,  G01N33/49 ,  G01N2021/3148 ,  G01N2021/4709 ,  G01N2021/475 ,  G01N2201/0221 ,  G01N2201/0631 ,  G01N2201/0636

Abstract: A method and apparatus for noninvasively measuring the concentration of a target analyte in a sample matrix using a fiberless transflectance probe is described. It includes directing a beam of electromagnetic radiation, consisting of at least two components of different wavelengths, to the sample matrix and conducting the backscattered radiation to a detector which outputs a signal indicative of the differential absorption of the two wavelengths in the sample matrix. The transflectance probe comprises a tapered tubular housing having an inner reflective surface, an optical rod having an outer reflective surface, and a detection window which serves as an interface between the probe and the surface of the sample matrix. The method and apparatus described are particularly useful in measuring the concentration of glucose in tissue containing blood.

公开(公告)号：US20130258076A1

公开(公告)日：2013-10-03

申请号：US13793079

申请日：2013-03-11

Applicant: DAINIPPON SCREEN MFG, CO., LTD.

Inventor： Hiroki FUJIMOTO ,  Masayoshi KOBAYASHI ,  Takashi MIYAKE ,  Sanzo MORIWAKI

IPC: H04N7/18

CPC classification number: H04N7/18 ,  G01N21/253 ,  G01N21/255 ,  G01N2201/0631 ,  G01N2201/0634 ,  G01N2201/067

Abstract: A preliminary image is obtained by irradiating illumination light, whose light quantity distribution is set at a standard state, to a specimen obtained by injecting fluid into a well from an illuminator capable of arbitrarily setting the light quantity distribution, for example, by a liquid crystal shutter, and a luminance distribution of the preliminary image is detected. As a result, luminance nonuniformity in the preliminary image is canceled by performing imaging with a light quantity distribution of illumination light to be incident on the well set such that an incident light amount is larger in a part with lower luminance.

Abstract translation: 通过将其光量分布设定为标准状态的照明光照射到能够从能够任意设定光量分布的照明装置将液体注入到井中而获得的试样，获得初步图像，例如通过液晶 快门，并且检测到初步图像的亮度分布。 结果，通过利用入射到套筒上的照明光的光量分布进行成像，使得入射光量在具有较低亮度的部分中较大，来抵消预备图像中的亮度不均匀性。

公开(公告)号：US20120087143A1

公开(公告)日：2012-04-12

申请号：US13376249

申请日：2011-04-28

Applicant: Andy Hill

Inventor： Andy Hill

IPC: F21V8/00 ,  F21V29/00 ,  F21V5/00

CPC classification number: G02B21/084 ,  F21W2131/406 ,  F21Y2115/10 ,  G01N21/8806 ,  G01N2021/8816 ,  G01N2021/8822 ,  G01N2201/0631 ,  G01N2201/0638 ,  G02B21/10 ,  G02B27/0927

Abstract: A ring light illuminator with annularly arranged light sources is disclosed. To each light source there corresponds a beam shaper comprising a light collector, a homogenizing means for light from the light source, and an imaging means for imaging an output of the homogenizing means into an area to be illuminated. The homogenizing means in embodiments is a rod, into which light from the light collector is directed. The end of the rod opposite the light collector is imaged by the imaging means into the area to be illuminated.

Abstract translation: 公开了一种具有环形布置的光源的环形照明器。 对于每个光源，对应于包括光收集器的光束整形器，用于来自光源的光的均匀化装置和用于将均匀化装置的输出成像到待照射区域的成像装置。 在实施例中的均质装置是一个杆，来自光收集器的光被引向该杆。 与光收集器相对的杆的端部通过成像装置成像到要照明的区域中。

公开(公告)号：US07928408B2

公开(公告)日：2011-04-19

申请号：US11345262

申请日：2006-02-01

Applicant: Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

Inventor： Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

IPC: G01N21/64

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source; an integrator for giving the light irradiated from the light source a uniform intensity distribution; a sample holder having a plurality of sample channels on which the samples are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

Abstract translation: 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 多通道荧光测量光学系统，其将光照射到多个样品通道上并检测从样品辐射的荧光，包括：光源; 用于给从光源照射的光均匀的强度分布的积分器; 具有多个样品通道的样品架，样品安装在样品通道上，其中采样由积分器发出的光退出; 以及在积分器和样品保持器之间的分束器，用于以预定比例分割入射光。 由于使用光纤束和光电二极管检测荧光图像的光强度，因此可以大大降低制造成本，并且可以使光学系统小型化。

公开(公告)号：US06796697B1

公开(公告)日：2004-09-28

申请号：US10140486

申请日：2002-05-07

Applicant: Chris Bragg ,  Daniel Scott ,  Eliezer Rosengaus

Inventor： Chris Bragg ,  Daniel Scott ,  Eliezer Rosengaus

IPC: F21V704

CPC classification number: G02B6/02 ,  G01N21/8806 ,  G01N21/9501 ,  G01N21/956 ,  G01N2021/8812 ,  G01N2201/0631 ,  G01N2201/0635 ,  G01N2201/0638 ,  G01N2201/0806 ,  G01N2201/0826 ,  G02B5/0252 ,  G02B5/32 ,  G02B6/04 ,  G02B6/4298

Abstract: An illumination delivery system provides a spatially and angularly uniform shaped beam output with sufficient intensity to illuminate a sample surface for defect inspection. Light is transmitted through a shaped fiber optic bundle, a homogenizer, a diffuser, and an optional focusing optics system.

Abstract translation: 照明传送系统提供具有足够强度的空间和角度均匀成形的光束输出，以照射样品表面进行缺陷检查。 光通过成形的光纤束，均质器，扩散器和可选的聚焦光学系统传输。