公开(公告)号：US20230003515A1

公开(公告)日：2023-01-05

申请号：US17942813

申请日：2022-09-12

Applicant: The Boeing Company ,  FemtoMetrix, Inc.

Inventor： Jeffrey H. Hunt ,  Jianing Shi ,  John Paul Changala

IPC: G01B11/24 ,  G01J3/10 ,  G01J3/44 ,  G01N21/63 ,  G01N21/65

Abstract: Surface sensing methods for imaging a scanned surface of a sample via sum-frequency vibrational spectroscopy are disclosed herein. The methods include exposing a sampled location of the scanned surface to a visible light beam and exposing the sampled location to a tunable infrared beam such that the tunable infrared beam is at least partially coincident with the visible light beam. The methods also include varying a frequency of the tunable infrared beam an inducing optical resonance within an imaged structure that extends at least partially within the sampled location. The methods further include receiving at least a portion of an emitted light beam from the sampled location and scanning the visible light beam and the runnable infrared beam across the scanned portion of the scanned surface. The methods also include generating an image of the scanned portion of the scanned surface based upon the receiving and the scanning.

公开(公告)号：US11536664B2

公开(公告)日：2022-12-27

申请号：US17705325

申请日：2022-03-27

Applicant: KING FAISAL UNIVERSITY

Inventor： Chawki Awada ,  Mohammed Ba Abdullah

IPC: G01J3/44 ,  G01N21/65

Abstract: The method for detecting a biomolecule by surface-enhanced Raman spectroscopy is a spectroscopic method of detecting a virus in a biological sample. A target substrate is prepared by depositing nanoparticles of a metal on a substrate of silicon nanowires. The nanoparticles may be gold, silver or a combination thereof. The far-field Raman spectra of at least one biomolecule associated with the virus are obtained. The biological fluid sample to be tested is then applied on the target substrate, and the surface-enhanced Raman spectroscopy spectra of the biological fluid sample on the target substrate are obtained. The far-field Raman spectra of the at least one biomolecule are compared against the surface-enhanced Raman spectroscopy spectra of the biological fluid sample on the target substrate.

公开(公告)号：US11513075B2

公开(公告)日：2022-11-29

申请号：US16478859

申请日：2017-10-12

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Akira Takahashi ,  Shunsuke Matsuda ,  Takayuki Miyashita ,  Mitsuharu Miwa

IPC: G01J3/44 ,  G01N21/64 ,  A61B5/00 ,  G01N21/27

Abstract: An observation device is an observation device observing an observation target and includes: an emission light source that generates emission light; a projection light source that generates projection light; a scanning mirror that scans the emission light and the projection light toward the observation target along the same optical path; a light guide optical system that guides detection target light generated in the observation target in accordance with emission of the emission light without it passing through the scanning mirror; an optical detector that detects the detection target light guided by the light guide optical system; and a control unit that controls an intensity of the projection light on the basis of a result of the detection of the detection target light.

公开(公告)号：US20220373392A1

公开(公告)日：2022-11-24

申请号：US17763957

申请日：2020-10-28

Applicant: TimeGate Instruments Oy

Inventor： Lauri Kurki ,  Ilkka Alasaarela ,  Jussi Tenhunen

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/14 ,  G01J3/26 ,  G01J3/18

Abstract: An apparatus for measuring time-resolved optical spectrum includes a light source, a sensor for collecting, forming, manipulating and measuring the intensity of the optical radiation, and a controller coupled to the light source and sensor. The sensor includes at least one optical delay element to provide a time delay to a first portion of the optical radiation. The sensor arrangement further includes an optical spectral disperser to split the delayed first portion and the second portion of the optical radiation into dispersed radiation having a plurality of wavelengths, and a sensor element configured to receive each wavelength of the dispersed radiation on a different spatial region, and measure the light intensity associated with each wavelength of the dispersed radiation. The controller collects the light intensity associated with each wavelength of the dispersed radiation measured by the sensor element to form a time-resolved optical spectrum.

公开(公告)号：US11499919B2

公开(公告)日：2022-11-15

申请号：US17204956

申请日：2021-03-18

Applicant: Ali Bavali ,  Alireza Mashhadi ,  Amir Jafargholi ,  Mohsen Hashemi ,  Farzad Mokhtari

Inventor： Ali Bavali ,  Alireza Mashhadi ,  Amir Jafargholi ,  Mohsen Hashemi ,  Farzad Mokhtari

IPC: G01N21/64 ,  G01J3/44 ,  G01N33/02 ,  G01N23/20016

Abstract: A method for determining sucrose concentration in honey. The method includes preparing a sample of honey, stimulating the sample by emitting a first laser beam on the sample in a first stimulation direction, detecting a fluorescence spectrum from a first fluorescence emission emitted from the sample in a first detection direction, detecting a first pair of fluorescence peaks and a second pair of peak wavelengths in the fluorescence spectrum, and determining a sucrose concentration based on one of the first pair and the second pair utilizing a database. The database includes a plurality of predetermined sucrose concentrations associated with the first pair or the second pair.

公开(公告)号：US11497403B2

公开(公告)日：2022-11-15

申请号：US16308306

申请日：2017-06-10

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Sinisa Vukelic ,  Gerard A. Ateshian

IPC: G01J3/44 ,  A61B5/00 ,  G01J3/02

Abstract: The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.

公开(公告)号：US20220299370A1

公开(公告)日：2022-09-22

申请号：US17613760

申请日：2020-05-27

Applicant: Wuxi Biologics Ireland Limited

Inventor： Jun HU ,  Gong CHEN ,  Yongjun QIN ,  Weichang ZHOU

IPC: G01J3/44 ,  C12M1/00 ,  G01N21/65

Abstract: A Raman spectroscopy integrated perfusion cell culture system for monitoring and auto-controlling perfusion cell culture, comprising: a bioreactor, comprising: (1) an interior chamber for receiving a cell culture, (2) a port for feeding nutrient materials from a feed reservoir into the interior chamber, (3) a port for auto-bleeding from the interior chamber, and (4) a port for continuously harvesting materials from the interior chamber with the help of a cell retention system; a Raman analyzer, comprising (i) one or more Raman probes which are immersed into the bioreactor and is configured to collect Raman spectrum in the bioreactor, and (ii) a host computer which is configured to receive the Raman spectrum collected and transferred by the Raman probe and turn it into values; and a controller in communication with the Raman analyzer, the feed reservoir and an auto-bleeding device, the controller being configured to receive the values from the Raman analyzer and compare them with preset parameters, based on results from comparing, the controller further being configured to control the feed reservoir for adjusting the feeding rate of nutrient materials into the bioreactor, and being configured to control the auto-bleeding device for auto-bleeding materials from the bioreactor. A process for monitoring and auto-controlling perfusion cell culture by using this system.

公开(公告)号：US11448551B2

公开(公告)日：2022-09-20

申请号：US17055069

申请日：2019-05-20

Applicant: GRINTECH GmbH

Inventor： Gregor Matz ,  Bernhard Messerschmidt

IPC: G01J3/02 ,  A61B5/00 ,  G01J3/44 ,  G01N21/65 ,  G02B6/02 ,  G02B6/024 ,  G02B26/10 ,  G02B27/12 ,  A61B1/00 ,  G02B27/10 ,  A61B1/06 ,  A61B1/07

Abstract: In an embodiment an optical arrangement includes a multicore fiber having at least a first fiber core configured to guide a first illumination light and a second fiber core configured to guide a second illumination light, wherein the multicore fiber comprises a fiber scanner configured to deflect the multicore fiber or the multicore fiber is followed by a mirror scanner; and a wavelength dispersive beam combiner configured to spatially superimpose the first illumination light and the second illumination light in an object space.

公开(公告)号：US11442019B2

公开(公告)日：2022-09-13

申请号：US16444597

申请日：2019-06-18

Applicant: VIRTUAL FLUID MONITORING SERVICES LLC

Inventor： Chris Morton ,  Scott Rudder

IPC: G01J3/44 ,  G01N21/65 ,  G01N1/42

Abstract: Systems, methods, and computer-program products for fluid analysis and monitoring are disclosed. Embodiments include a sampling system and an analytical system connected to the sampling system. A fluid may be routed through the sampling system and data may be collected from the fluid via the sampling system. The sampling system may process and transmit the data to the analytical system. The analytical system may include a command and control system to receive and store the data in a database and compare the data to existing data for the fluid in the database to identify conditions in the fluid. The system may further include a cooling system configured to enclose at least one member of the fluid analysis system. The cooling system encloses at least one member of the fluid analysis system including the excitation system, the detection system, the fluid inlet, the sample chamber, the Raman probe, and combinations thereof.

公开(公告)号：US11442011B2

公开(公告)日：2022-09-13

申请号：US17259232

申请日：2019-07-10

Applicant: SUGENTECH, INC.

Inventor： Sungrak Kim ,  Huije Lee ,  Hosung Sohn ,  Seungbum Yoo ,  Mi-Jin Sohn

IPC: G01J3/44 ,  G01N21/64

Abstract: A fluorescent standard strip, according to the present invention, is for testing the reliability of the fluorescence intensity of a fluorescent strip used for an analyzer, the fluorescent standard strip having an effect whereby, for devices using a fluorescent substance, the inter-device deviation in fluorescence intensity is reduced, fluorescent signal linearity per fluorescent concentration level is secured, and device reliability may be tested by periodically checking faults, errors, deviations, etc. of the devices. In addition, the fluorescent standard strip, according to the present invention, has an effect whereby, even in an environment and state where light is frequently irradiated, the reduction of fluorescence intensity according to time may be minimized, i.e., the same level of fluorescence intensity may be maintained for a long period.