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公开(公告)号：US09371369B2
公开(公告)日：2016-06-21
申请号：US14168973
申请日：2014-01-30
Applicant: Amunix Operating Inc.
Inventor： Volker Schellenberger , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , Wayne To , Jeffrey L. Cleland
IPC: A61K38/16 , A61K38/18 , C07K14/61 , C07K14/46 , C07K14/545 , C07K14/00 , C07K14/605 , C07K14/745 , C07K14/47
CPC classification number: C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
Abstract: The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的生物活性蛋白质的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及使用这些组合物治疗葡萄糖相关疾病，代谢疾病 ，凝血障碍和生长激素相关的疾病和病症。
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2.发明授权Binding fusion proteins, binding fusion protein-drug conjugates, XTEN-drug conjugates and methods of making and using same 有权结合融合蛋白，结合融合蛋白 - 药物偶联物，XTEN-药物共轭物及其制备和使用方法公开(公告)号：US09249211B2
公开(公告)日：2016-02-02
申请号：US13631361
申请日：2012-09-28
Applicant: Amunix Operating Inc.
Inventor： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething
CPC classification number: C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
Abstract: The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸重组多肽（XTEN）连接的靶向部分，结合融合蛋白 - 药物共轭组合物和XTEN-药物共轭组合物的结合融合蛋白组合物，编码组合物和载体的分离的核酸和含有该重组多肽的宿主细胞 以及使用这些组合物治疗疾病，病症和病症的方法。
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3.发明申请公开(公告)号：US20150344862A1
公开(公告)日：2015-12-03
申请号：US14710077
申请日：2015-05-12
Applicant: Amunix Operating Inc.
Inventor： Volker SCHELLENBERGER , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
IPC: C12N9/64
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子IX凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20150037359A1
公开(公告)日：2015-02-05
申请号：US14381199
申请日：2013-02-27
Applicant: AMUNIX OPERATING, INC.
Inventor： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
CPC classification number: A61K38/24 , A61K47/64 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07K5/0205
Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
Abstract translation: 本发明涉及延伸的重组多肽（XTEN）组合物，包含与用于与药理活性有效载体缀合的交联剂连接的XTEN和XTEN的缀合物组合物，制备高度纯化的XTEN的方法，制备XTEN-接头和XTEN-有效载体缀合物的方法 以及使用XTEN-交联剂和XTEN-有效载体组合物的方法。
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公开(公告)号：US20190153115A1
公开(公告)日：2019-05-23
申请号：US15753716
申请日：2016-08-26
Applicant: AMUNIX OPERATING INC.
Inventor： Volker SCHELLENBERGER , Fan YANG , Desiree THAYER , Bee-Cheng SIM , Chia-Wei WANG
Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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Patent Agency Ranking
公开(公告)号：US10000543B2
公开(公告)日：2018-06-19
申请号：US15365792
申请日：2016-11-30
Applicant: Amunix Operating Inc.
Inventor： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-wei Wang , Nathan Geething , Jeffrey L. Cleland
IPC: C07K14/605 , A61K38/00
CPC classification number: C07K14/605 , A23V2200/328 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N15/70 , C12P21/02 , Y10S514/866
Abstract: The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of glucose regulating peptide-related diseases, disorders, and conditions.
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公开(公告)号：US09938331B2
公开(公告)日：2018-04-10
申请号：US14970723
申请日：2015-12-16
Applicant: Amunix Operating Inc.
Inventor： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Nathaniel C. Gordon , Andreas Crameri , Mikhail Popkov
IPC: C07K1/00 , A61K38/24 , C07K14/00 , C07K14/56 , C07K7/06 , C07K7/08 , C07K14/415 , C12N15/10 , G01N33/68 , C07K14/47 , C07K14/53 , C07K14/61 , C07K14/535 , A61K38/00
CPC classification number: C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
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公开(公告)号：US09758776B2
公开(公告)日：2017-09-12
申请号：US15163603
申请日：2016-05-24
Applicant: Amunix Operating Inc.
Inventor： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
IPC: A61K38/36 , C07K14/745 , C12N9/64 , C07K14/00 , C12N15/70
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
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公开(公告)号：US20170247676A1
公开(公告)日：2017-08-31
申请号：US15427763
申请日：2017-02-08
Applicant: Amunix Operating Inc.
Inventor： Volker SCHELLENBERGER , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
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公开(公告)号：US20170240614A1
公开(公告)日：2017-08-24
申请号：US15434477
申请日：2017-02-16
Applicant: Eli Lilly and Company , Amunix Operating Inc.
Inventor： David Bruce BALDWIN , John Michael BEALS , Andrew Ihor KORYTKO , Bryant Rhodius McLAUGHLIN , Volker SCHELLENBERGER
CPC classification number: C07K14/72 , A61K38/179 , A61K38/1796 , A61K38/28 , A61K47/64 , C07K14/62 , C07K14/71 , C07K2319/31
Abstract: The present invention relates to the field of medicine and the treatment of diabetes or hyperglycemia within that field. More particularly, the invention relates to a compound that lowers blood glucose, pharmaceutical compositions containing such a compound, and therapeutic uses of such a compound.
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