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1.发明申请公开(公告)号：US20150344862A1
公开(公告)日：2015-12-03
申请号：US14710077
申请日：2015-05-12
Applicant: Amunix Operating Inc.
Inventor： Volker SCHELLENBERGER , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
IPC: C12N9/64
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子IX凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20180125988A1
公开(公告)日：2018-05-10
申请号：US15525819
申请日：2015-11-11
Applicant: AMUNIX OPERATING INC.
Inventor： Fan YANG , Volker SCHELLENBERGER , Sheng DING , Desiree THAYER , Chia-Wei WANG
CPC classification number: A61K47/551 , A61K47/6803 , A61K47/6855 , A61P35/00 , C07K14/00 , C07K2319/00 , C07K2319/01 , C07K2319/30 , C07K2319/50 , C07K2319/70 , C12N9/6421 , C12N15/70 , G01N2030/027
Abstract: The present disclosure provides drug conjugate compositions, and compositions and methods for preparing and using the same. In some embodiments, the present invention relates to targeted conjugate compositions comprising cysteine-containing domains (CCD) linked to targeting moieties, extended recombinant polypeptides (XTEN)and peptide cleavable moieties, with pharmacologically active payload drugs cross-linked to cysteine residues, resulting in compositions that can be cleaved by proteases associated with target tissues. The invention also provides methods of making the targeted conjugate compositions and methods of using the targeted conjugate compositions.
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公开(公告)号：US20160362672A1
公开(公告)日：2016-12-15
申请号：US15163603
申请日：2016-05-24
Applicant: Amunix Operating Inc.
Inventor： Volker SCHELLENBERGER , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
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公开(公告)号：US20190153115A1
公开(公告)日：2019-05-23
申请号：US15753716
申请日：2016-08-26
Applicant: AMUNIX OPERATING INC.
Inventor： Volker SCHELLENBERGER , Fan YANG , Desiree THAYER , Bee-Cheng SIM , Chia-Wei WANG
Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
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Patent Agency Ranking
公开(公告)号：US20170247676A1
公开(公告)日：2017-08-31
申请号：US15427763
申请日：2017-02-08
Applicant: Amunix Operating Inc.
Inventor： Volker SCHELLENBERGER , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
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公开(公告)号：US20170240614A1
公开(公告)日：2017-08-24
申请号：US15434477
申请日：2017-02-16
Applicant: Eli Lilly and Company , Amunix Operating Inc.
Inventor： David Bruce BALDWIN , John Michael BEALS , Andrew Ihor KORYTKO , Bryant Rhodius McLAUGHLIN , Volker SCHELLENBERGER
CPC classification number: C07K14/72 , A61K38/179 , A61K38/1796 , A61K38/28 , A61K47/64 , C07K14/62 , C07K14/71 , C07K2319/31
Abstract: The present invention relates to the field of medicine and the treatment of diabetes or hyperglycemia within that field. More particularly, the invention relates to a compound that lowers blood glucose, pharmaceutical compositions containing such a compound, and therapeutic uses of such a compound.
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公开(公告)号：US20160376344A1
公开(公告)日：2016-12-29
申请号：US15163561
申请日：2016-05-24
Applicant: Amunix Operating Inc.
Inventor： Volker SCHELLENBERGER , Pei-Yun CHANG , Fatbardha VARFAJ , John KULMAN , Tongyao LIU , Garabet G. TOBY , Haiyan JIANG , Robert PETERS , Deping WANG , Baisong MEI , Joshua SILVERMAN , Chia-Wei WANG , Benjamin SPINK , Nathan GEETHING
IPC: C07K14/755 , C07K14/00
CPC classification number: C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
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公开(公告)号：US20160199454A1
公开(公告)日：2016-07-14
申请号：US14912047
申请日：2014-08-14
Applicant: BIOGEN MA INC. , AMUNIX OPERATING INC.
Inventor： Tongyao LIU , Pei-Yun CHANG , John KULMAN , Volker SCHELLENBERGER , Haiyan JIANG , Robert T. PETERS , Ekta Seth CHHABRA
IPC: A61K38/37 , A61K9/00 , C07K14/00 , C07K14/755
Abstract: The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.
Abstract translation: 本发明提供了包含因子VIII（FVIII）多肽和XTEN多肽的嵌合蛋白。 FVIII多肽可以对血管性血友病因子（VWF）具有降低的亲和力。 适当大小的XTEN多肽在特定位置插入FVIII多肽中，以延长FVIII多肽的半衰期。 本发明还包括核苷酸，载体，宿主细胞和使用嵌合蛋白的方法，例如治疗出血疾病和病症。
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公开(公告)号：US20150038421A1
公开(公告)日：2015-02-05
申请号：US14317888
申请日：2014-06-27
Applicant: Amunix Operating Inc.
Inventor： Volker SCHELLENBERGER , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
IPC: C07K14/755 , C07K14/00
CPC classification number: C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
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