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公开(公告)号：US08810907B2
公开(公告)日：2014-08-19
申请号：US13193759
申请日：2011-07-29
Applicant: Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
Inventor： Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
IPC: G02B21/06
CPC classification number: G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
Abstract: A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
Abstract translation: 显微镜系统和方法允许观察积聚在组织中的荧光物质。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。
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2.发明申请公开(公告)号：US20100097618A1
公开(公告)日：2010-04-22
申请号：US12380286
申请日：2009-02-25
Applicant: Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
Inventor： Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
CPC classification number: G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
Abstract: A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
Abstract translation: 显微镜系统和方法允许观察积聚在组织中的荧光物质。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。
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3.发明授权公开(公告)号：US08705042B2
公开(公告)日：2014-04-22
申请号：US13479453
申请日：2012-05-24
Applicant: Michael Haisch , Christoph Hauger , Harmut Wolf , Joachim Hug , Brigitta Schwarz , Gerhard Gaida , Andreas Raabe
Inventor： Michael Haisch , Christoph Hauger , Harmut Wolf , Joachim Hug , Brigitta Schwarz , Gerhard Gaida , Andreas Raabe
IPC: G01J3/45
CPC classification number: G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
Abstract: A microscopy system and a microscopy method are provided for observing a fluorescent substance accumulated in a tissue. The microscopy system comprises a filter allowing to observe the tissue at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series.
Abstract translation: 提供显微镜系统和显微镜方法来观察积聚在组织中的荧光物质。 显微镜系统包括允许在可见光和荧光的同时观察组织的过滤器。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。
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4.发明申请公开(公告)号：US20120249771A1
公开(公告)日：2012-10-04
申请号：US13479453
申请日：2012-05-24
Applicant: Michael Haisch , Christoph HAUGER , Hartmut WOLF , Joachim HUG , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
Inventor： Michael Haisch , Christoph HAUGER , Hartmut WOLF , Joachim HUG , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
IPC: H04N7/18
CPC classification number: G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
Abstract: A microscopy system and a microscopy method are provided for observing a fluorescent substance accumulated in a tissue. The microscopy system comprises a filter allowing to observe the tissue at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series.
Abstract translation: 提供显微镜系统和显微镜方法来观察积聚在组织中的荧光物质。 显微镜系统包括允许在可见光和荧光的同时观察组织的过滤器。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。
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5.发明申请公开(公告)号：US20120194663A1
公开(公告)日：2012-08-02
申请号：US13193759
申请日：2011-07-29
Applicant: Michael HAISCH , Christoph HAUGER , Hartmut WOLF , Joachim HUG , Schwarz Brigitta , Gerhard GAIDA , Andreas RAABE
Inventor： Michael HAISCH , Christoph HAUGER , Hartmut WOLF , Joachim HUG , Schwarz Brigitta , Gerhard GAIDA , Andreas RAABE
IPC: H04N7/18
CPC classification number: G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
Abstract: A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
Abstract translation: 显微镜系统和方法允许观察积聚在组织中的荧光物质。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相关荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。
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Patent Agency Ranking
6.发明申请Microscopy system, microscopy method, and a method of treating an aneurysm 审中-公开显微镜系统，显微镜法和治疗动脉瘤的方法公开(公告)号：US20080013166A1
公开(公告)日：2008-01-17
申请号：US11901764
申请日：2007-09-19
Applicant: Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
Inventor： Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
CPC classification number: G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
Abstract: A microscopy system and a microscopy method are provided for observing a fluorescent substance accumulated in a tissue. The microscopy system comprises a filter allowing to observe the tissue at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
Abstract translation: 提供显微镜系统和显微镜方法来观察积聚在组织中的荧光物质。 显微镜系统包括允许在可见光和荧光的同时观察组织的过滤器。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。
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公开(公告)号：US20050010099A1
公开(公告)日：2005-01-13
申请号：US10815226
申请日：2004-03-30
Applicant: Andreas Raabe , Niels Frielinghaus , Jens Witte
Inventor： Andreas Raabe , Niels Frielinghaus , Jens Witte
CPC classification number: A61B90/36 , A61B2090/364
Abstract: The invention relates to a method for registering an image data set for visualizing internal areas of the body. The method can include determining the relative position of an imaging device and of an external body part associated with an internal area of the body and producing an image data set for the internal area of the body by means of the imaging device. The spatial position of the external body part is determined and the image data of the internal area of the body are registered or assigned according to relative position, with respect to the spatial position of the external body part, on the basis of the relative positional information.
Abstract translation: 本发明涉及一种用于注册用于可视化身体内部区域的图像数据集的方法。 该方法可以包括确定成像装置和与身体的内部区域相关联的外部身体部分的相对位置，并通过成像装置产生用于身体的内部区域的图像数据集。 确定外部身体部位的空间位置，根据相对位置信息，根据相对于外部身体部位的空间位置的相对位置登记或分配身体的内部区域的图像数据 。
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8.发明申请公开(公告)号：US20110168914A1
公开(公告)日：2011-07-14
申请号：US13072840
申请日：2011-03-28
Applicant: Michael HAISCH , Christoph HAUGER , Harmut WOLF , Joachim HUG , Schwarz BRIGITTA , Gerhard GAIDA , Andreas RAABE
Inventor： Michael HAISCH , Christoph HAUGER , Harmut WOLF , Joachim HUG , Schwarz BRIGITTA , Gerhard GAIDA , Andreas RAABE
CPC classification number: G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
Abstract: A microscopy system and method are provided allowing observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
Abstract translation: 提供了可以观察积聚在组织中的荧光物质的显微系统和方法。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。
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公开(公告)号：US07570987B2
公开(公告)日：2009-08-04
申请号：US10815226
申请日：2004-03-30
Applicant: Andreas Raabe , Niels Frielinghaus , Jens Witte
Inventor： Andreas Raabe , Niels Frielinghaus , Jens Witte
IPC: A61B5/05
CPC classification number: A61B90/36 , A61B2090/364
Abstract: The invention relates to a method for registering an image data set for visualizing internal areas of the body. The method can include determining the relative position of an imaging device and of an external body part associated with an internal area of the body and producing an image data set for the internal area of the body by means of the imaging device. The spatial position of the external body part is determined and the image data of the internal area of the body are registered or assigned according to relative position, with respect to the spatial position of the external body part, on the basis of the relative positional information.
Abstract translation: 本发明涉及一种用于注册用于可视化身体内部区域的图像数据集的方法。 该方法可以包括确定成像装置和与身体的内部区域相关联的外部身体部分的相对位置，并通过成像装置产生用于身体的内部区域的图像数据集。 确定外部身体部位的空间位置，根据相对位置信息，根据相对于外部身体部位的空间位置的相对位置登记或分配身体的内部区域的图像数据 。
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10.发明授权公开(公告)号：US08189201B2
公开(公告)日：2012-05-29
申请号：US12380286
申请日：2009-02-25
Applicant: Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
Inventor： Michael Haisch , Christoph Hauger , Hartmut Wolf , Joachim Hug , Schwarz Brigitta , Gerhard Gaida , Andreas Raabe
IPC: G01B11/02
CPC classification number: G02B27/0172 , A61B5/0066 , A61B5/0071 , A61B5/0086 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/4795 , G01N21/6428 , G01N21/6458 , G01N2021/1782 , G01N2021/6421 , G02B7/002 , G02B21/16 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/365 , G02B21/367 , G02B21/368 , G02B2027/0134 , G02B2027/0138 , G02B2027/014
Abstract: A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.
Abstract translation: 显微镜系统和方法允许观察积聚在组织中的荧光物质。 可以在可见光和荧光的同时观察组织。 可以观察到与可见光图像重叠的一系列先前记录的荧光图像。 可以自动确定一系列图像的结束。 可以在系列的这种自动确定的端部将热保护过滤器插入到照明系统的光束路径中。 此外，可以分析荧光图像以识别其相干荧光部分。 可以生成相干部分的外围线的表示，并且可以仅从相干部分获得深度轮廓数据。 用于激发荧光的照明光束可以被调制以改善荧光图像的对比度。
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