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Patent Agency Ranking
公开(公告)号：US09706977B2
公开(公告)日：2017-07-18
申请号：US12519659
申请日：2007-12-21
CPC classification number: A61B8/08 , A61B5/0095 , A61B8/4281 , G01N29/0672 , G01N29/228 , G01N29/2418 , G01N2291/011 , G01N2291/015 , G01N2291/0237
Abstract: A thermoacoustic imaging apparatus comprises an electromagnetic radiation source, an acoustic signal detection probe and a radiation responsive acoustic signal generator outside the sample area. The detection probe arrangement detects both signals generated in the sample area in response to the electromagnetic irradiation and an acoustic signal from the radiation responsive acoustic signal generator that has traveled through the sample area. An acoustic transmission parameter such as a speed of sound or absorption as a function of a position in the sample area is computed from signals due to the radiation responsive acoustic signal generator. The acoustic transmission parameter is used to correct the computation of a thermoacoustic image from detections due to acoustic signals generated in the sampled area.
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2.发明申请COMMON DETECTOR FOR COMBINED RAMAN SPECTROSCOPY-OPTICAL COHERENCE TOMOGRAPHY 有权用于组合拉曼光谱光学相干光谱的通用检测器公开(公告)号：US20120188538A1
公开(公告)日：2012-07-26
申请号：US13012529
申请日：2011-01-24
Applicant: Chetan A. Patil , Anita Mahadevan-Jansen , Antonius Gerardus Johannes Maria van Leeuwen , Jeroen Kalkman
Inventor： Chetan A. Patil , Anita Mahadevan-Jansen , Antonius Gerardus Johannes Maria van Leeuwen , Jeroen Kalkman
CPC classification number: G01B9/02044 , A61B3/102 , A61B5/0066 , A61B5/0075 , A61B5/442 , A61B5/443 , G01B9/0203 , G01B9/02091 , G01J3/44 , G01J3/453 , G01N21/4795 , G01N21/65 , G01N2021/1787
Abstract: In one aspect of the present invention, an apparatus includes a first light source for generating a broadband light, and a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting the received broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, and a sample arm optically coupled to the beamsplitter and the second light source for combining the sample light and the monochromatic light, delivering the combined sample and monochromatic light to the target of interest, collecting a backscattering light and a Raman scattering light that are generated from interaction of the sample light and the monochromatic light with the target of interest, respectively, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path, and a single detector optically coupled to the beamsplitter for collecting the interference signal.
Abstract translation: 在本发明的一个方面中，一种装置包括用于产生宽带光的第一光源和用于产生单色光的第二光源，光学耦合到第一光源的分束器，用于接收宽带光并分离所接收的 将宽带光转换为参考光和采样光，参考臂光耦合到分束器，用于接收参考光并将接收到的参考光返回到分光器中;以及样品臂，光学耦合到分束器和第二光源，用于组合 样品光和单色光，将组合的样品和单色光输送到感兴趣的目标，分别收集从样品光和单色光与感兴趣的目标的相互作用产生的后向散射光和拉曼散射光 ，将后向散射光返回到分束器中以产生 在分束器中返回的后向散射光和返回的参考光之间产生干涉信号，并将拉曼散射光引导到输出光路中，以及单个检测器，其光耦合到分束器以收集干扰信号。
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3.发明授权Common detector for combined raman spectroscopy-optical coherence tomography 有权联合拉曼光谱 - 光学相干断层扫描的共同检测器公开(公告)号：US08553219B2
公开(公告)日：2013-10-08
申请号：US13012529
申请日：2011-01-24
Applicant: Chetan A. Patil , Anita Mahadevan-Jansen , Antonius Gerardus Johannes Maria Van Leeuwen , Jeroen Kalkman
Inventor： Chetan A. Patil , Anita Mahadevan-Jansen , Antonius Gerardus Johannes Maria Van Leeuwen , Jeroen Kalkman
CPC classification number: G01B9/02044 , A61B3/102 , A61B5/0066 , A61B5/0075 , A61B5/442 , A61B5/443 , G01B9/0203 , G01B9/02091 , G01J3/44 , G01J3/453 , G01N21/4795 , G01N21/65 , G01N2021/1787
Abstract: An apparatus includes first and second light sources for respectively generating broadband and monochromatic lights, a beamsplitter optically coupled to the first light source for splitting the broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, a sample arm optically coupled to the beamsplitter and the second light source for combining the sample and monochromatic lights, delivering the combined light to the target of interest, collecting a backscattering light and a Raman scattering light generated from interaction of the combined light with the target of interest, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path.
Abstract translation: 一种装置包括用于分别产生宽带和单色光的第一和第二光源，光耦合到第一光源的分束器，用于将宽带光分成参考光和采样光;参考臂，光耦合到分束器，用于接收 参考光并将接收到的参考光返回到分光器中，样品臂光耦合到分束器和第二光源，用于组合样品和单色光，将组合的光输送到感兴趣的目标，收集后向散射光和拉曼 由组合光与感兴趣的目标的相互作用产生的散射光，将后向散射光返回到分光器中，以便在分光器中产生返回的后向散射光与返回的参考光之间的干涉信号，并将拉曼散射光引导到 输出光路。
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公开(公告)号：US20100041987A1
公开(公告)日：2010-02-18
申请号：US12519659
申请日：2007-12-21
CPC classification number: A61B8/08 , A61B5/0095 , A61B8/4281 , G01N29/0672 , G01N29/228 , G01N29/2418 , G01N2291/011 , G01N2291/015 , G01N2291/0237
Abstract: A thermoacoustic imaging apparatus comprises an electromagnetic radiation source configured to irradiate a sample area and an acoustic signal detection probe arrangement for detecting acoustic signals. A radiation responsive acoustic signal generator is added outside the sample area. The detection probe arrangement detects both signals generated in a sample area in response to the irradiation and an acoustic signal from the radiation responsive acoustic signal generator that has traveled through the sample area. A computing system distinguishes first acoustic signal detections attributed to the acoustic signal generated by the radiation responsive acoustic signal generator and second acoustic signal detections attributed to the acoustic signals generated by the sample area. The computing system performs a tomographic computation of an acoustic transmission parameter as a function of a position in the sample area from the first acoustic signal detections. The acoustic transmission parameter may be a speed of sound or absorption. The acoustic transmission parameter may be used to correct the computation of a thermoacoustic image.
Abstract translation: 热声成像装置包括被配置为照射样本区域的电磁辐射源和用于检测声信号的声信号检测探头装置。 辐射响应声信号发生器被添加到样本区域外部。 检测探针装置响应于照射而检测在样本区域中产生的信号和来自已经穿过样本区域的辐射响应声信号发生器的声信号。 计算系统区分归因于由辐射响应声信号发生器产生的声信号的第一声信号检测和归因于由样本区产生的声信号的第二声信号检测。 计算系统根据第一声信号检测，根据样本区域中的位置进行声传输参数的断层计算。 声学传播参数可以是声音或吸收的速度。 声传播参数可用于校正热声图像的计算。
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5.发明申请METHOD OF DETERMINING A PARAMETER REPRESENTING AN ACOUSTIC PROPERTY OF A MATERIAL 审中-公开确定代表材料声学性质的参数的方法公开(公告)号：US20090227870A1
公开(公告)日：2009-09-10
申请号：US11574477
申请日：2004-08-31
Applicant: Roy Gerardus Maria Kolkman , Antonius Gerardus Johannes Maria van Leeuwen , Wiendelt Steenbergen
Inventor： Roy Gerardus Maria Kolkman , Antonius Gerardus Johannes Maria van Leeuwen , Wiendelt Steenbergen
CPC classification number: G01N29/06 , A61B5/0095 , A61B5/14532 , G01N29/50 , G01N2291/02475 , G01N2291/103
Abstract: The invention relates to a method and system for determining a parameter representing an acoustic property of a material. The method comprises: generating an acoustic pressure wave in said material originating from a localized position; placing a plurality of acoustic receivers (6, 7) at mutually differing distances from the acoustic source (3); transforming a plurality of measured acoustic signals to represent field values in a common computational point; computing a signal representing a measure of overlap between said transformed plurality of acoustic signals as a function of said numerical estimates of said acoustic property parameter and deriving said acoustic property parameter from said overlap signal. Since the invention uses acoustic sources that are well localized in the material, the velocity calculations are simple and the geometry of the acoustic receivers in relation to the acoustic source can be exactly taken into account.
Abstract translation: 本发明涉及一种用于确定表示材料的声学特性的参数的方法和系统。 该方法包括：在源自局部位置的所述材料中产生声压波; 将多个声学接收器（6,7）放置在与声源（3）相距不同的距离处; 将多个测量的声信号变换为在公共计算点中的场值; 计算表示所述经变换的多个声信号之间重叠的度量的信号，作为所述声学属性参数的所述数值估计的函数，并从所述重叠信号导出所述声学特性参数。 由于本发明使用在材料中良好定位的声源，所以速度计算是简单的，并且可以将与声源相关的声接收器的几何形状精确地考虑在内。
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