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    DEVICES AND METHODS FOR ONE-STEP STATIC OR CONTINUOUS MAGNETIC SEPARATION
    1.
    发明申请
    DEVICES AND METHODS FOR ONE-STEP STATIC OR CONTINUOUS MAGNETIC SEPARATION 审中-公开

    公开(公告)号：US20200171509A1

    公开(公告)日：2020-06-04

    申请号：US16614501

    申请日：2018-04-02

    Applicant: BIOMAGNETIC SOLUTIONS LLC

    Inventor： Paul A. Liberti

    IPC: B03C1/01 ,  G01N33/543

    Abstract: This invention relates to the static or continuous magnetic separation of specific entities from mixtures where the separation of target entities is clone in a one-step process. It is universally applicable to the harvest or removal of such entities for processing of biological molecules, cells of all types, virus particles, and the like, and for small- to large-scale separations of the same. By manipulation of the scientific principles that underlie this invention, specific targets can be conveniently captured for analysis, harvested or subjected to further processing on a collection surface free of bystander components. The principles employed and the methods disclosed completely obviate the need for washing of targeted entities such as cycles of resuspension and magnetic separation for removal of contaminating substances in the case of static separation or complex cycles of sample introduction and harvest to perform continuous processing.

    RECOVERY AND PURITY OF MAGNETICALLY TARGETED CELLS
    2.
    发明申请
    RECOVERY AND PURITY OF MAGNETICALLY TARGETED CELLS 审中-公开
    磁性靶向细胞的恢复和纯度

    公开(公告)号：US20160168531A1

    公开(公告)日：2016-06-16

    申请号：US14937855

    申请日：2015-11-10

    Applicant: BIOMAGNETIC SOLUTIONS LLC

    Inventor： Paul A. Liberti

    IPC: C12M1/00

    CPC classification number: C12M47/04

    Abstract: Methods and apparatus for separation of rare cells of interest from a biological sample are provided. The present methods and apparatus effectively reduce fragile rare cell exposure to manipulations that adversely impact cell integrity and collection.

    Abstract translation: 提供了从生物样品中分离目的稀有细胞的方法和装置。 本发明的方法和装置有效地减少易受伤害的罕见细胞暴露于不利地影响细胞完整性和收集的操作。

    Rigid chamber for cell separation from a flexible disposable bag
    4.
    发明授权
    Rigid chamber for cell separation from a flexible disposable bag 有权

    公开(公告)号：US11413378B2

    公开(公告)日：2022-08-16

    申请号：US17052717

    申请日：2018-05-08

    Applicant: BIOMAGNETIC SOLUTIONS LLC ,  Joseph Francis Liberti

    Inventor： Paul A Liberti ,  Dustin W Ritter

    IPC: A61M1/02 ,  A61M1/36 ,  A61J1/16 ,  G01N33/58

    Abstract: Method consists of placing a flexible container within a rigid frame and expanding the container by pneumatic or hydraulic pressure such that the walls of the container conform to the inside walls of the rigid frame thus forming a well-defined chamber. The system has the capability of reducing the volume of the chamber by adjusting the distance between the walls of the rigid container. The methods and systems so described are applicable to closed sterile systems that employ immunomagnetic isolation or purging of components from blood products. By providing a fixed volume and at least one surface upon which targeted entities can be magnetically deposited, target cells in the case of positive isolations can be magnetically held, flushed with wash buffers over them to remove entrapped cells and finally the recovery of product of very high purifies and at high yields.

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