公开(公告)号：US20180038863A1

公开(公告)日：2018-02-08

申请号：US15553707

申请日：2016-02-25

Applicant: BIOMAGNETIC SOLUTIONS LLC

Inventor： Paul A. Liberti ,  Todor R. Khristov

IPC: G01N33/569 ,  G01N33/543 ,  C12N5/0783

CPC classification number: G01N33/56972 ,  C12N5/0636 ,  C12N2501/998 ,  G01N33/54326 ,  G01N33/54346 ,  G01N2333/7051 ,  G01N2333/70521

Abstract: Methods are provided for the rapid and efficient separation of target bioentities.

公开(公告)号：US20150153259A1

公开(公告)日：2015-06-04

申请号：US14559109

申请日：2014-12-03

Applicant: BioMagnetic Solutions, LLC

Inventor： Paul A. Liberti ,  Jason R. Stephens ,  Todor R. Khristov ,  Theodore L. Liberti

IPC: G01N1/44 ,  G01N1/04

CPC classification number: G01N1/04 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/286 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/0439

Abstract: Disclosed is a high gradient magnetic separation apparatus for recovering magnetic ally labeled target entities from viscous and/or complex test media. The target entities are captured on a ferromagnetic element in which a magnetic field gradient is induced by a magnetic field source. The apparatus is designed to perform various operations on captured target entities. Methods of using the apparatus are also disclosed, e.g., for isolation of circulating tumor cells.

Abstract translation: 公开了一种用于从粘性和/或复杂测试介质中回收磁性标记目标实体的高梯度磁选机。 目标实体被捕获在其中由磁场源引起磁场梯度的铁磁元件上。 该设备被设计为对捕获的目标实体执行各种操作。 还公开了使用该装置的方法，例如用于分离循环肿瘤细胞。

公开(公告)号：US12012591B2

公开(公告)日：2024-06-18

申请号：US17316054

申请日：2021-05-10

Applicant: Joseph Francis Liberti ,  BIOMAGNETIC SOLUTIONS LLC.

Inventor： Paul A. Liberti ,  Todor R. Khristov ,  Dustin W. Ritter

IPC: C12N13/00 ,  A61M1/36 ,  B01D15/38 ,  B01F31/23 ,  B01F33/452 ,  B03C1/01 ,  B03C1/033 ,  B03C1/034 ,  B03C1/28 ,  G01N33/543

CPC classification number: C12N13/00 ,  A61M1/3618 ,  B01D15/3885 ,  B01F31/23 ,  B01F33/452 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/034 ,  B03C1/288 ,  G01N33/54326 ,  B03C2201/18 ,  B03C2201/22 ,  B03C2201/26

Abstract: An apparatus and methods are provided for the magnetic separation of target bioentities. The apparatus includes a fluid chamber and a magnetic element for drawing target bioentities toward a collection surface of the fluid chamber. The apparatus may include a positioning assembly operable to variable change the position and orientation f the fluid chamber relative to the magnetic element.