公开(公告)号：US12036214B2

公开(公告)日：2024-07-16

申请号：US17253193

申请日：2019-06-14

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

Inventor： Sonali Sandip Bharate ,  Vikas Kumar ,  Mubashir Javed Mintoo ,  Dilip Manikrao Mondhe ,  Sandip Bibishan Bharate ,  Ram Vishwakarma

IPC: A61K31/453 ,  A61K9/10 ,  A61K9/20 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61K47/40 ,  A61P35/00 ,  C07D405/04

CPC classification number: A61K31/453 ,  A61K9/10 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61K47/40 ,  A61P35/00

Abstract: The present invention is related to the novel solid dispersion formulations of an anticancer compound of formula A and a process for preparing the same wherein the anticancer compound is formulated with hydrophilic polymer. The said formulation showed enhanced dissolution of the anticancer compound and improved in-vivo anticancer activity. The said formulations are useful for the treatment of various types of cancer.

公开(公告)号：US10696688B2

公开(公告)日：2020-06-30

申请号：US15774520

申请日：2016-11-21

Applicant: Council of Scientific and Industrial Research

Inventor： Sandip Bibishan Bharate ,  Shashi Bhushan ,  Shabber Mohammed ,  Santosh Kumar Guru ,  Sonali Sandip Bharate ,  Vikas Kumar ,  Girish Mahajan ,  Mubashir Javed Mintoo ,  Dilip Manikrao Mondhe ,  Ram Vishwakarma

IPC: C07D493/04 ,  C07D495/04 ,  C07D471/14

Abstract: The present invention relates to fused pyrimidines of formulae I and II wherein, R1, R2 are as herein described. The present invention particularly relates to isoform selective PI3Kα inhibition and their medicinal use as anticancer agents.