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1.发明申请Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis 有权用于治疗与血管发生相关的超增殖性疾病和疾病的取代的4-氨基 - 吡咯并嗪衍生物公开(公告)号：US20100063038A1
公开(公告)日：2010-03-11
申请号：US12085880
申请日：2006-12-01
Applicant: Julie Dixon , Barton Phillips , Furahi Achebe , Harold Kluender , Jason Newcom , Kyle Parcella , Stephen J. O'Connor , Steven Magnuson , Zhenqui Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler
Inventor： Julie Dixon , Barton Phillips , Furahi Achebe , Harold Kluender , Jason Newcom , Kyle Parcella , Stephen J. O'Connor , Steven Magnuson , Zhenqui Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler
IPC: A61K31/53 , C07D487/04 , A61K31/5377 , A61K31/541 , C12N5/00 , A61P35/00
CPC classification number: C07D487/04
Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
Abstract translation: 本发明涉及新颖的吡咯并三嗪化合物，含有这些化合物的药物组合物，以及用作治疗高增殖和/或血管生成障碍的那些化合物或组合物作为唯一试剂或与其它活性成分组合的用途。
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2.发明申请SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权取代的4-氨基吡咯烷酮衍生物有助于治疗与增殖性疾病有关的高血压病和疾病公开(公告)号：US20100179125A1
公开(公告)日：2010-07-15
申请号：US12552923
申请日：2009-09-02
Applicant: Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
Inventor： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
IPC: A61K31/53 , C07D487/04 , A61K31/5377 , A61K31/541 , A61K31/553 , A61P35/00 , C12N5/00
CPC classification number: C07D487/04
Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
Abstract translation: 本发明涉及新颖的吡咯并三嗪化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。
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![Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases](/abs-image/US/2013/04/30/US08431695B2/abs.jpg.150x150.jpg)
3.发明授权Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases 失效吡咯并[2,1-f] [1,2,4]三嗪-4-基胺治疗癌症和其他过度增生性疾病的IGF-1R激酶抑制剂公开(公告)号：US08431695B2
公开(公告)日：2013-04-30
申请号：US12084411
申请日：2006-11-02
Applicant: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
Inventor： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC: C07D487/04 , C07D413/02 , C07D417/02 , A61K31/53 , A61P35/00
CPC classification number: C07D487/04
Abstract: This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
Abstract translation: 本发明涉及新的式（I）化合物。 式（I）其中可变基团如说明书和权利要求中所定义，含有它们的药物组合物，以及使用它们治疗癌症的方法。
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Patent Agency Ranking
公开(公告)号：US06960601B2
公开(公告)日：2005-11-01
申请号：US10255049
申请日：2002-09-24
Applicant: Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
Inventor： Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
IPC: A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P25/30 , A61P35/00 , C07D233/90 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/08 , C07D417/14 , A61K31/445
CPC classification number: C07D401/06 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14
Abstract: This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
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公开(公告)号：US08143393B2
公开(公告)日：2012-03-27
申请号：US12085880
申请日：2006-12-01
Applicant: Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
Inventor： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
IPC: C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61P35/00
CPC classification number: C07D487/04
Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
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6.发明授权Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权用于治疗高增殖性疾病和与血管发生相关的疾病的取代的4-氨基吡咯并三嗪衍生物公开(公告)号：US08129379B2
公开(公告)日：2012-03-06
申请号：US12552923
申请日：2009-09-02
Applicant: Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
Inventor： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
IPC: A61K31/53 , A61P35/00 , C07D487/04 , C07D417/02 , C07D413/02
CPC classification number: C07D487/04
Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
Abstract translation: 本发明涉及新颖的吡咯并三嗪化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。
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![Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases](/abs-image/US/2011/12/01/US20110294776A1/abs.jpg.150x150.jpg)
7.发明申请Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases 失效吡咯并[2,1-F] [1,2,4]三嗪-4-基胺IGF-1R激酶抑制剂治疗癌症和其他过度增生性疾病公开(公告)号：US20110294776A1
公开(公告)日：2011-12-01
申请号：US12084411
申请日：2006-11-02
Applicant: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
Inventor： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC: A61K31/53 , C07D498/04 , A61P35/00 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D487/04 , A61K31/5377
CPC classification number: C07D487/04
Abstract: This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
Abstract translation: 本发明涉及新的式（I）化合物。 式（I）其中可变基团如说明书和权利要求中所定义，含有它们的药物组合物，以及使用它们治疗癌症的方法。
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公开(公告)号：US20050256167A1
公开(公告)日：2005-11-17
申请号：US11133751
申请日：2005-05-20
Applicant: Roger Smith , Stephen O'Connor , Stephan-Nicholas Wirtz , Wai Wong , Soongyu Choi , Harold Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
Inventor： Roger Smith , Stephen O'Connor , Stephan-Nicholas Wirtz , Wai Wong , Soongyu Choi , Harold Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
IPC: A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P25/30 , A61P35/00 , C07D233/90 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/08 , C07D417/14 , A61K31/4172 , C07D43/02
CPC classification number: C07D401/06 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14
Abstract: This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
Abstract translation: 本发明涉及已被发现抑制食欲并引起体重减轻的取代的咪唑衍生物。 本发明还提供了合成化合物的方法，包含该化合物的药物组合物，以及使用这些组合物诱导体重减轻和治疗肥胖症和肥胖相关疾病的方法。
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