公开(公告)号：US20120107499A1

公开(公告)日：2012-05-03

申请号：US13168715

申请日：2011-06-24

Applicant: Daniel H. Traynor ,  Hao Xu ,  Henry G. Traynor ,  Daniel H. Traynor ,  John Carson ,  Martin S. Flacks ,  Rachel Sullivan

Inventor： Daniel H. Traynor ,  Hao Xu ,  Henry G. Traynor ,  Daniel H. Traynor ,  John Carson ,  Martin S. Flacks ,  Rachel Sullivan

IPC: B29B9/12

CPC classification number: A61K8/11 ,  A61K8/0279 ,  A61K8/585 ,  A61Q19/00

Abstract: This invention relates to a method for forming hollow silica-based particles suitable for containing one or more active ingredients or for containing other smaller particles which may include one or more active ingredients. The method comprises preparing an emulsion including a continuous phase that is polar or non-polar and a dispersed phase comprising droplets including (i) a polar active ingredient when the continuous phase is non-polar or (ii) a non-polar active ingredient when the continuous phase is polar; and adding a silica precursor to the emulsion such that the silica precursor can be emulsion templated on the droplets to form hollow silica-based particles. The silica precursor has the general formula (I): R1x—Si—(OR2)y, wherein R1 is selected from substituted and unsubstituted alkyl, substituted and unsubstituted aryl, alcohols, amines, amides, aldehydes, acids, esters, and functional groups having an unsaturated carbon-carbon bond, R2 is an alkyl group, x+y=4, and y=1, 2 or 3. The —OR2 group is a hydrolyzable organic group that exhibits an ability to form a silicon-oxygen bond chain as a result of hydrolysis and condensation.

Abstract translation: 本发明涉及一种形成中空二氧化硅基颗粒的方法，该方法适于含有一种或多种活性成分或含有其它可包含一种或多种活性成分的较小颗粒。 该方法包括制备包含极性或非极性的连续相的乳液和包含液滴的分散相，包括（i）连续相为非极性时的极性活性成分或（ii）非极性活性成分， 连续相为极性; 并将二氧化硅前体添加到乳液中，使得二氧化硅前体可以在液滴上乳液模板化以形成中空二氧化硅基颗粒。 二氧化硅前体具有通式（I）：R1x-Si-（OR2）y，其中R1选自取代和未取代的烷基，取代和未取代的芳基，醇，胺，酰胺，醛，酸，酯和官能团 具有不饱和碳 - 碳键，R2是烷基，x + y = 4，y = 1,2或3. -OR2基团是表现出形成硅 - 氧键键的能力的可水解的有机基团 作为水解和缩合的结果。

公开(公告)号：US20060135522A1

公开(公告)日：2006-06-22

申请号：US11314300

申请日：2005-12-21

Applicant: John Carson ,  Scott Dax ,  Bart DeCorte ,  Li Liu ,  Mark McDonnell ,  James McNally

Inventor： John Carson ,  Scott Dax ,  Bart DeCorte ,  Li Liu ,  Mark McDonnell ,  James McNally

IPC: A61K31/53 ,  A61K31/506 ,  A61K31/452 ,  C07D409/14 ,  C07D405/14

CPC classification number: C07D405/14 ,  C07D405/04 ,  C07D409/14 ,  C07D413/14

Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

公开(公告)号：US20060127344A1

公开(公告)日：2006-06-15

申请号：US11302667

申请日：2005-12-14

Applicant: Albert Zofchak ,  Paul Slavashevich ,  John Carson

Inventor： Albert Zofchak ,  Paul Slavashevich ,  John Carson

IPC: A61K8/42

CPC classification number: A61K8/062 ,  A61K8/06 ,  A61K8/39 ,  A61K8/42 ,  A61K8/86 ,  A61Q5/00 ,  A61Q5/06 ,  A61Q19/00

Abstract: The use of novel nonionic polymeric thickeners that produce cosmetically useful emulsions of an oil phase and a water phase is described. The thickeners of choice are the urethane dimers of ethoxylated fatty alcohols. These materials were not anticipated to have emulsifying properties. Also, it has been found that the esters of ethoxylated polyols show similar emulsifying behavior, although their uses are limited by their inherent susceptibility towards hydrolysis. Further, many of the emulsions produced with these emulsifiers have a dilatant or shear thickening rheology that is unusual and has unique cosmetic applications. In addition, it is possible to produce high internal phase oil-in-water emulsions, with oil phase concentrations greater than 70%, using these emulsifiers. Finally, many of the emulsions, especially the high internal phase ones, have a characteristic “ring” or vibration that is apparent when their container is tapped. This is a characteristic of so called “microemulsions” that has not been observed in conventional appearing, white (albeit dilatant) emulsions.

Abstract translation: 描述了使用产生油相和水相的化妆品有用的乳液的新型非离子聚合物增稠剂。 所选择的增稠剂是乙氧基化脂肪醇的聚氨酯二聚体。 这些材料预计不会具有乳化性能。 此外，已经发现，乙氧基化多元醇的酯显示出类似的乳化行为，尽管它们的用途受其对水解的固有敏感性的限制。 此外，用这些乳化剂生产的许多乳液具有不常见的膨胀或剪切增稠流变学，并且具有独特的化妆品应用。 此外，使用这些乳化剂可以生产油相浓度大于70％的高内相水包油乳液。 最后，许多乳液，特别是高内相的乳液，具有特征性的“环”或振动，当它们的容器被攻丝时是明显的。 这是所谓的“微乳液”的特征，在常规出现的白色（虽然是膨胀的）乳液中没有观察到。

公开(公告)号：US20050123287A1

公开(公告)日：2005-06-09

申请号：US10726487

申请日：2003-12-04

Applicant: Ramgopal Vissa ,  Venkata Burada ,  John Carson

Inventor： Ramgopal Vissa ,  Venkata Burada ,  John Carson

IPC: F26B3/30

CPC classification number: F26B3/30 ,  B21K29/00

Abstract: A novel flexible infrared device is provided for heating surfaces in a uniform manner not available previously. The heater is designed in a manner so as to allow “hugging” of the surface by attaching the heater module to at least two swivel points located above the heating plane. In this manner the common problems encountered with heating dies by IR heaters is overcome.

Abstract translation: 提供了一种新颖的柔性红外线装置，用于以前所未有的均匀方式加热表面。 加热器的设计方式是通过将加热器模块附接到位于加热平面上方的至少两个旋转点来允许表面“拥抱”。 以这种方式克服了通过IR加热器对加热模具遇到的常见问题。

公开(公告)号：US20050084510A1

公开(公告)日：2005-04-21

申请号：US10690327

申请日：2003-10-20

Applicant: John Carson

Inventor： John Carson

IPC: A61K8/04 ,  A61K8/25 ,  A61K8/26 ,  A61K8/58 ,  A61K8/92 ,  A61Q15/00 ,  A61Q19/00 ,  A61K7/00

CPC classification number: A61K8/044 ,  A61K8/064 ,  A61K8/25 ,  A61K8/26 ,  A61K8/585 ,  A61K8/922 ,  A61Q15/00 ,  A61Q19/00

Abstract: A stable suspension formed of a plurality of water particles each of which is encapsulated with an amorphous silica-based material, where that plurality of encapsulated water particles is dispersed in a continuous phase formed of one or more carbon-containing materials, where the stable suspension does not include added emulsifiers. A method to prepare such stable suspensions. Personal care products comprising Applicant's stable suspensions, including skin protectants, sunscreens, moisturizers, vehicles for medicaments, antiperspirants, deodorants, pressurized products such as aerosol products, vehicles for skin treatment products and vehicles for makeup, area of the eye, lip products, mascara and color cosmetic products.

Abstract translation: 由多个水颗粒形成的稳定的悬浮液，每个水颗粒用无定形二氧化硅基材料包封，其中多个包封的水颗粒分散在由一种或多种含碳材料形成的连续相中，其中稳定的悬浮液 不包括添加的乳化剂。 制备这种稳定悬浮液的方法。 个人护理产品包括申请人的稳定悬浮液，包括皮肤保护剂，防晒剂，保湿剂，药物载体，止汗剂，除臭剂，加压产品如气溶胶产品，皮肤治疗产品的车辆和化妆车辆，眼睛区域，唇部产品，睫毛膏 和彩色化妆品。

公开(公告)号：US20050009860A1

公开(公告)日：2005-01-13

申请号：US10873527

申请日：2004-06-22

Applicant: John Carson ,  Ellen Codd ,  Christine Razler ,  Andrea Works ,  Mark McDonnell ,  James McNally

Inventor： John Carson ,  Ellen Codd ,  Christine Razler ,  Andrea Works ,  Mark McDonnell ,  James McNally

IPC: C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D471/08 ,  A61K31/473

CPC classification number: C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D471/08

Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

Abstract translation: 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。

公开(公告)号：US06708141B1

公开(公告)日：2004-03-16

申请号：US09407383

申请日：1999-09-28

Applicant: James C. Schaff ,  John Carson ,  Leslie Loew

Inventor： James C. Schaff ,  John Carson ,  Leslie Loew

IPC: G06G760

CPC classification number: G16H50/50 ,  G06F19/00

Abstract: A method and apparatus for modeling cellular structure is disclosed. The system incorporates a theoretical hypotheses of cellular physiology into a simulation framework that allows direct comparison of simulation results with experimental data. The description of the biological model is kept independent of the solution by the use of an integrated anatomical and physiological modeling language. This framework allows complex heterogeneous intracellular chemical simulations to be built with little or no knowledge of the underlying numerical methods. Because the simulation results are easily compared to the experimental results, the user can more easily confirm the hypothesis.

Abstract translation: 公开了一种用于建模细胞结构的方法和装置。 该系统将细胞生理学的理论假设纳入到模拟框架中，可以将模拟结果与实验数据进行直接比较。 通过使用综合的解剖和生理建模语言，生物学模型的描述与解决方案无关。 这个框架允许复杂的异种细胞内化学模拟被建立，很少或根本没有知识的基础数值方法。 由于仿真结果与实验结果相比较，用户可以更容易地确认假设。

公开(公告)号：US06148587A

公开(公告)日：2000-11-21

申请号：US116629

申请日：1998-07-16

Applicant: Gregory E. McDonald ,  Andrew W. Moehlenbrock ,  John Carson

Inventor： Gregory E. McDonald ,  Andrew W. Moehlenbrock ,  John Carson

IPC: B31B1/14 ,  B31B23/00 ,  B65B43/28 ,  B65D33/00 ,  B65B1/04

CPC classification number: B65B43/123 ,  B31B1/00 ,  B31B23/00 ,  B65B43/28 ,  B65D33/007 ,  B31B2219/14 ,  B31B2219/28 ,  B31B2219/922 ,  B31B2237/10 ,  B31B2237/60

Abstract: A bag includes a first panel with at least one access hole in it, and a second panel without a hole corresponding to the at least one hole of the first panel. Preferably, two holes are present, preferably near the bag mouth. The panels are substantially equal in length. The bag can be easily opened by described bag opening means, without the need for vacuum or air to open the bag. The bag can be used in conjuction with otherwise conventional taped bag systems. A metod of making the bag, a bag opening system, a method of opening the bag, and a packaging system are also disclosed.

Abstract translation: 袋包括其中具有至少一个进入孔的第一面板和不具有与第一面板的至少一个孔对应的孔的第二面板。 优选地，存在两个孔，优选在袋口附近。 面板的长度基本相等。 该袋可以通过所述袋打开装置容易地打开，而不需要真空或空气来打开袋子。 该袋可以与传统的胶带袋系统结合使用。 还公开了制造该袋，袋打开系统，打开袋的方法和包装系统的组合。

公开(公告)号：US1882317A

公开(公告)日：1932-10-11

申请号：US40036529

申请日：1929-10-17

Applicant: JOHN CARSON CORNELL

Inventor： CORNELL FRED A

IPC: B65B25/04

CPC classification number: B65B25/046

公开(公告)号：US09192548B2

公开(公告)日：2015-11-24

申请号：US13168715

申请日：2011-06-24

Applicant: Daniel H. Traynor ,  Hao Xu ,  Henry G. Traynor ,  Daniel H. Traynor ,  John Carson ,  Martin S. Flacks ,  Rachel Sullivan

Inventor： Daniel H. Traynor ,  Hao Xu ,  Henry G. Traynor ,  John Carson ,  Martin S. Flacks ,  Rachel Sullivan

IPC: B01J13/22 ,  A61K8/11 ,  A61K8/58 ,  A61Q19/00 ,  A61K8/02

CPC classification number: A61K8/11 ,  A61K8/0279 ,  A61K8/585 ,  A61Q19/00

Abstract: This invention relates to a method for forming hollow silica-based particles suitable for containing one or more active ingredients or for containing other smaller particles which may include one or more active ingredients. The method comprises preparing an emulsion including a continuous phase that is polar or non-polar and a dispersed phase comprising droplets including (i) a polar active ingredient when the continuous phase is non-polar or (ii) a non-polar active ingredient when the continuous phase is polar; and adding a silica precursor to the emulsion such that the silica precursor can be emulsion templated on the droplets to form hollow silica-based particles. The silica precursor has the general formula (I): R1x—Si—(OR2)y, wherein R1 is selected from substituted and unsubstituted alkyl, substituted and unsubstituted aryl, alcohols, amines, amides, aldehydes, acids, esters, and functional groups having an unsaturated carbon-carbon bond, R2 is an alkyl group, x+y=4, and y=1, 2 or 3. The —OR2 group is a hydrolyzable organic group that exhibits an ability to form a silicon-oxygen bond chain as a result of hydrolysis and condensation.

Abstract translation: 本发明涉及一种形成中空二氧化硅基颗粒的方法，该方法适于含有一种或多种活性成分或含有其它可包含一种或多种活性成分的较小颗粒。 该方法包括制备包含极性或非极性的连续相的乳液和包含液滴的分散相，包括（i）连续相为非极性时的极性活性成分或（ii）非极性活性成分， 连续相为极性; 并将二氧化硅前体添加到乳液中，使得二氧化硅前体可以在液滴上乳液模板化以形成中空二氧化硅基颗粒。 二氧化硅前体具有通式（I）：R1x-Si-（OR2）y，其中R1选自取代和未取代的烷基，取代和未取代的芳基，醇，胺，酰胺，醛，酸，酯和官能团 具有不饱和碳 - 碳键，R2是烷基，x + y = 4，y = 1,2或3. -OR2基团是表现出形成硅 - 氧键键的能力的可水解的有机基团 作为水解和缩合的结果。