公开(公告)号：US20110170095A1

公开(公告)日：2011-07-14

申请号：US12953550

申请日：2010-11-24

Applicant: Kevin Peter Menard ,  Enrique Lozano Diz ,  Richard Spragg

Inventor： Kevin Peter Menard ,  Enrique Lozano Diz ,  Richard Spragg

IPC: G01J3/44

CPC classification number: G01N25/4866 ,  G01N21/65 ,  G01N25/4833

Abstract: A combination DSC testing and Raman spectroscopy system is provided for running investigations on a single sample in the same experiment. A DSC instrument includes a set of optics, which allows an associated Raman unit to emit a pulsed laser that intermittently directs a laser signal to the sample and to collect the Raman signal while simultaneously running a DSC experiment on the same sample. The DSC has a vessel adapted to contain the sample, a thermal analysis environment is adapted to hold the vessel. An associated temperature control apparatus changes the temperature of the analysis environment between temperature endpoints to observe the sample at various transitions. The Raman spectroscopy unit is configured to generate laser pulses which stimulate emission of Raman spectra to provide further information about the sample without introducing excessive noise in the DSC aspect of the investigation.

Abstract translation: 提供了组合DSC测试和拉曼光谱系统，用于在同一实验中对单个样品进行调查。 DSC仪器包括一组光学元件，其允许相关联的拉曼单元发射脉冲激光，其间歇地将激光信号引导到样品并收集拉曼信号，同时在相同样品上进行DSC实验。 DSC具有适于容纳样品的容器，热分析环境适于容纳容器。 相关的温度控制装置在温度端点之间改变分析环境的温度，以在各种转变处观察样品。 拉曼光谱单元被配置为产生激光脉冲，其激发拉曼光谱的发射以提供关于样品的进一步信息，而不在调查的DSC方面引入过多的噪声。

公开(公告)号：US5308982A

公开(公告)日：1994-05-03

申请号：US956519

申请日：1992-10-05

Applicant: Juan Ivaldi ,  David H. Tracy ,  Robert Hoult ,  Richard Spragg

Inventor： Juan Ivaldi ,  David H. Tracy ,  Robert Hoult ,  Richard Spragg

IPC: G01N21/27 ,  G01J3/28 ,  G01J3/433 ,  G01N21/73 ,  G01N21/25

CPC classification number: G01J3/433 ,  G01J3/28

Abstract: A method for determining concentration of an analyte in a sample includes generating a spectrum of a selected analyte and interferents, generating a spectrum of an unknown sample, computing first and second derivatives of the sample spectrum, deriving a matrix model that includes the analyte spectrum and the derivatives, and applying the matrix model to the sample spectrum so as to yield a parameter representing concentration of the selected analyte in the unknown sample. Multiple linear least squares regression is utilized to fit the model and calculate the parameter.

Abstract translation: 用于确定样品中分析物浓度的方法包括产生所选分析物和干扰物的光谱，产生未知样品的光谱，计算样品光谱的第一和第二导数，导出包括分析物光谱的矩阵模型，以及 衍生物，并将矩阵模型应用于样本光谱，以产生表示未知样品中所选分析物浓度的参数。 利用多元线性最小二乘回归拟合模型并计算参数。