公开(公告)号：US20220373560A1

公开(公告)日：2022-11-24

申请号：US17767250

申请日：2020-10-08

Applicant: University of Utah Research Foundation

Inventor： Kathryn A. Peterson ,  Gerald J. Gleich ,  Mark D. Yandell ,  Edwin Lin ,  Hedieh Saffari

IPC: G01N33/68

Abstract: Disclosed are methods of diagnosing and treating a subject with active or inactive eosinophilic esophagitis (EoE). The methods may include the steps of detecting whether a level of one or more immunoglobulin antibodies is elevated in an esophageal secretion sample obtained from a subject, diagnosing the subject with active EoE when the level of one or more immunoglobulin antibodies in the sample is elevated above a pre-determined cut-off value and diagnosing the subject with inactive EoE when the level of one or more immunoglobulin antibodies level in the sample is below a pre-determined cut-off value; and treating the subject diagnosed with active EoE.

公开(公告)号：US20250069700A1

公开(公告)日：2025-02-27

申请号：US18949394

申请日：2024-11-15

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Carson Hinton Holt ,  Mark D. Yandell

IPC: G16B30/10 ,  G06F16/176 ,  G16B50/50

Abstract: A method for facilitating rapid genome sequence analysis includes accessing an output stream of an alignment process that includes aligned reads of a biological sequence that are aligned to a reference genome. The method also includes distributing the aligned reads to a plurality of computing nodes based on genomic position. Each of the plurality of computing nodes is assigned to a separate data bin of a plurality of data bins associated with genomic position. The method also includes, for at least one aligned read determined to overlap separate data bins of the plurality of data bins, duplicating the at least one aligned read and distributing the at least one aligned read to separate computing nodes of the plurality of computing nodes that are assigned to the separate data bins.