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公开(公告)号：US20220189632A1
公开(公告)日：2022-06-16
申请号：US17436743
申请日：2019-10-03
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Brian E. Brooks , Gilles J. Benoit , Peter O. Olson , Tyler W. Olson , Himanshu Nayar , Frederick J. Arsenault , Nicholas A. Johnson , Susan L. Woulfe , Mark A. Tomai
IPC: G16H50/20 , G16H50/50 , G16H20/10 , A61B5/00 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/145 , A61M16/00
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for selecting settings for a treatment of a patient. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of input settings for providing a treatment to a patient based on a causal model that measures current causal relationships between input settings and effects of treatments on the patient; ii) receiving a measure of an effect of the treatment on the patient; and iii) adjusting, based on the measure of the effect of the treatment on the patient, the causal model.
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公开(公告)号：US20150044279A1
公开(公告)日：2015-02-12
申请号：US14507139
申请日：2014-10-06
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Richard L. Miller , Mark A. Tomai , Ross M. Kedl , Isidro Angelo Eleazar Zarraga , Ronnie Ortiz , James D. Stoesz , Paul D. Wightman
CPC classification number: A61K47/6911 , A61K31/44 , A61K39/00 , A61K39/39 , A61K47/543 , Y02A50/41 , Y02A50/488 , Y02A50/489
Abstract: Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.
Abstract translation: 通过在局部组织区域内沉积IRM贮库制剂来提供IRM化合物的免疫应答的方法和组合物，其提供活性IRM在局部组织区域内延长的停留时间。
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公开(公告)号：US20230346954A1
公开(公告)日：2023-11-02
申请号：US18002122
申请日：2021-06-10
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： George W. Griesgraber , Mark A. Tomai , Hannah C. Cohen , Devon Hunerdosse
IPC: A61K47/55 , C07D471/04
CPC classification number: A61K47/55 , C07D471/04
Abstract: Imidazoquinoline compounds, salts thereof, conjugates thereof, pharmaceutical compositions containing the compounds and conjugates, and methods of use of such compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals.
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公开(公告)号：US20220180979A1
公开(公告)日：2022-06-09
申请号：US17436840
申请日：2019-10-28
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Brian E. Brooks , Gilles J. Benoit , Peter O. Olson , Tyler W. Olson , Himanshu Nayar , Frederick J. Arsenault , Nicholas A. Johnson , Susan L. Woulfe , Mark A. Tomai
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for designing a clinical trial. In one aspect, the method comprises repeatedly performing the following: i) selecting, from a population of patients, patients for being treated with the treatment using a configuration of input settings, wherein the configuration is selected based on a causal model that measures current causal relationships between input settings and a measure of success of the clinical trial; ii) determining the measure of success of the clinical trial for which patients were selected using the certain configuration of input settings; and iii) adjusting, based on the measure of success of the clinical trial, the causal model.
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Patent Agency Ranking
公开(公告)号：US09801947B2
公开(公告)日：2017-10-31
申请号：US14507139
申请日：2014-10-06
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Richard L. Miller , Mark A. Tomai , Ross M. Kedl , Isidro Angelo Eleazar Zarraga , Ronnie Ortiz , James D. Stoesz , Paul D. Wightman
CPC classification number: A61K47/6911 , A61K31/44 , A61K39/00 , A61K39/39 , A61K47/543 , Y02A50/41 , Y02A50/488 , Y02A50/489
Abstract: Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.
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公开(公告)号：US20230406855A1
公开(公告)日：2023-12-21
申请号：US18251578
申请日：2021-10-15
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： George W. Griesgraber , Mark A. Tomai , Hannah C. Cohen , Devon M. Hunerdosse
IPC: C07D471/04 , A61K47/54
CPC classification number: C07D471/04 , A61K47/545
Abstract: Imidazoquinoline compounds, salts thereof, conjugates thereof, pharmaceutical compositions containing the compounds and conjugates, and methods of use of such compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals.
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公开(公告)号：US20220178899A1
公开(公告)日：2022-06-09
申请号：US17436770
申请日：2019-10-03
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Brian E. Brooks , Gilles J. Benoit , Peter O. Olson , Tyler W. Olson , Himanshu Nayar , Frederick J. Arsenault , Nicholas A. Johnson , Susan L. Woulfe , Mark A. Tomai
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for optimizing a process of manufacturing a biologic pharmaceutical. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of input settings for manufacturing a batch of a biologic pharmaceutical based on a causal model that measures current causal relationships between input settings and a measure of a quality of batches of the biological pharmaceutical; ii) determining a measure of the quality of a batch of the biological pharmaceutical manufactured using the configuration of input settings; and iii) adjusting, based on the measure of the quality of the batch of the biological pharmaceutical, the causal model.
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公开(公告)号：US20220172830A1
公开(公告)日：2022-06-02
申请号：US17436797
申请日：2019-10-03
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Brian E. Brooks , Gilles J. Benoit , Peter O. Olson , Tyler W. Olson , Himanshu Nayar , Frederick J. Arsenault , Nicholas A. Johnson , Susan L. Woulfe , Mark A. Tomai
IPC: G16H40/20
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for controlling operations of one or more healthcare facilities. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of input settings for controlling operations of the healthcare facilities based on a causal model that measures current causal relationships between input settings and a measure of success of operations at the healthcare facilities; ii) receiving a measure of success of the operation of the healthcare facilities while controlled using the configuration of input settings; and iii) adjusting, based on the measure of success of the operation of the healthcare facilities while controlled using the configuration of input settings, the causal model.
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公开(公告)号：US20150110784A1
公开(公告)日：2015-04-23
申请号：US14580369
申请日：2014-12-23
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Mark A. Tomai , Gary W. Gullikson , David M. Hammerbeck , Elaine A. Egging , Michael J. Reiter , Christopher D. Gram , John P. Vasilakos
IPC: A61K31/4745 , A61K39/395 , A61K31/573
CPC classification number: A61K31/4745 , A61K31/00 , A61K31/573 , A61K39/3955 , A61K39/39566 , A61K45/06 , A61K2039/505 , A61K2300/00
Abstract: The present invention provides therapeutic combinations that include an immune response modifier (IRM) component and an anti-inflammatory component. The inventions further provide methods of treating a condition by administering to one having the condition a therapeutic combination that includes an IRM component and an anti-inflammatory component.
Abstract translation: 本发明提供包括免疫应答调节剂（IRM）组分和抗炎组分的治疗组合。 本发明还提供了通过给予具有包括IRM组分和抗炎组分的治疗组合的患者的治疗病症的方法。
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