公开(公告)号：US3894061A

公开(公告)日：1975-07-08

申请号：US37830573

申请日：1973-07-11

Applicant: ABBOTT LAB

Inventor： CHU DANIEL TIM-WO ,  GARMAISE DAVID LYON

IPC: C07C251/24 ,  C07C67/00 ,  C07C233/00 ,  C07C241/00 ,  C07D413/10 ,  D07B3/04 ,  C07C143/82

CPC classification number: C07D413/10 ,  C07C233/00

Abstract: A number of specific anilino derivatives of chelocardin having high antibiotic activity are described. These new derivatives show unusually low toxicity and consequently a very high therapeutic index as chemotherapeutic agents against gramnegative organisms.

公开(公告)号：US3878223A

公开(公告)日：1975-04-15

申请号：US34062273

申请日：1973-03-12

Applicant: ABBOTT LAB

Inventor： GARMAISE DAVID LYON ,  PARIS GERARD YVON

IPC: C07D231/40 ,  C07D261/14 ,  C07D49/20

CPC classification number: C07D231/40 ,  C07D261/14 ,  Y10S514/87

Abstract: Acrylamides of N-containing heterocyclic moieties that optionally carry a further hetero atom adjacent to the said N and/or methyl substituent(s) on said hetero ring and at least one chlorine atom adjacent to the double bond of the acrylic moiety have been found to have anti-inflammatory properties at reasonably low dosage levels.

Abstract translation: 已经发现，含氮杂环部分的丙烯酰胺任选地在所述杂环上邻近所述N和/或甲基取代基和与丙烯酸部分的双键相邻的至少一个氯原子携带另外的杂原子， 在相当低的剂量水平下具有抗炎性质。

公开(公告)号：US3907889A

公开(公告)日：1975-09-23

申请号：US37110373

申请日：1973-06-18

Applicant: ABBOTT LAB

Inventor： INABA MAKOTO ,  BERNSTEIN EDITH ,  GARMAISE DAVID LYON

IPC: C07C233/00 ,  C07C103/19

CPC classification number: C07C251/72

Abstract: A number of specific hydrazone derivatives of chelocardin having high antibiotic activity are described. These new derivatives show unusually low toxicity and consequently, a very high therapeutic index as chemotherapeutic agents against gramnegative organisms.

Abstract translation: 描述了具有高抗生素活性的许多具有特异性的hydraz ard醛腙衍生物。 这些新衍生物显示异常低的毒性，因此作为抗革兰氏阴性生物体的化学治疗剂具有非常高的治疗指数。

公开(公告)号：US3705902A

公开(公告)日：1972-12-12

申请号：US3705902D

申请日：1971-05-03

Applicant: ABBOTT LAB

Inventor： GARMAISE DAVID LYON ,  PARIS GERARD YVON ,  PLOTNIKOFF NICHOLAS PETER

IPC: C07D471/04 ,  C07D31/44

CPC classification number: C07D471/04

Abstract: 2-ARALKYL-8-FLUORO-1,2,3,4-TETRAHYDRO-5-PROPIONYLPYRIDO(4,3-B)INDOLES HAVE BEEN FOUND TO BE POWERFUL ANTIDEPRESSANTS WHEN ADMINISTERED TO WARM-BLOODED ANIMALS.

公开(公告)号：US3910906A

公开(公告)日：1975-10-07

申请号：US37110473

申请日：1973-06-18

Applicant: ABBOTT LAB

Inventor： BERNSTEIN EDITH ,  INABA MAKOTO ,  GARMAISE DAVID LYON

IPC: C07D295/22

CPC classification number: C07D295/22

Abstract: A number of specific hydrazone derivatives of chelocardin having high antibiotic activity are described. These new derivatives show unusually low toxicity and consequently, a very high therapeutic index as chemotherapeutic agents against gramnegative organisms.

公开(公告)号：US3687961A

公开(公告)日：1972-08-29

申请号：US3687961D

申请日：1971-05-03

Applicant: ABBOTT LAB

Inventor： BERNSTEIN EDITH ,  GARMAISE DAVID LYON ,  PLOTNIKOFF NICHOLAS PETER

IPC: C07D471/04 ,  C07D31/42

CPC classification number: C07D471/04

Abstract: 8-Fluoro-2-(3-(4-fluorophenylanilino)propyl)-1,2,3,4,tetrahydro-5H -pyrido(4,3-b)indole has been found to be a very useful tranquilizer at low dosages when administered to warmblooded animals. The new compound and its non-toxic acid addition salts have an oral ED50 of about 20 mg./kg. and an oral LD50 of 700 mg./kg.

Abstract translation: 8-氟-2- [3-（4-氟苯基苯胺基）丙基] -1,2,3,4-四氢-5H-吡啶并[4,3-b]吲哚已被发现是非常有用的镇定剂 施用于温血动物时的低剂量。 新化合物及其无毒酸加成盐具有约20mg./kg的口服ED 50。 口服LD50为700mg./kg。

公开(公告)号：US3687960A

公开(公告)日：1972-08-29

申请号：US3687960D

申请日：1971-04-21

Applicant: ABBOTT LAB

Inventor： BERNSTEIN EDITH ,  GARMAISE DAVID LYON ,  PLOTNIKOFF NICHOLAS PETER

IPC: C07D471/04 ,  C07D31/42

CPC classification number: C07D471/04

Abstract: 2-(3-Hydroxypropyl)-8-fluoro-1,2,3,4-tetrahydro-5H-pyrido(4,3b)indole has been found to be a powerful anti-depressant when administered to warm-blooded animals.

Abstract translation: 已经发现2-（3-羟基丙基）-8-氟-1,2,3,4-四氢-5H-吡啶并[4,3-b]吲哚在施用于温血动物时是强大的抗抑郁剂 。