公开(公告)号：US3878223A

公开(公告)日：1975-04-15

申请号：US34062273

申请日：1973-03-12

Applicant: ABBOTT LAB

Inventor： GARMAISE DAVID LYON ,  PARIS GERARD YVON

IPC: C07D231/40 ,  C07D261/14 ,  C07D49/20

CPC classification number: C07D231/40 ,  C07D261/14 ,  Y10S514/87

Abstract: Acrylamides of N-containing heterocyclic moieties that optionally carry a further hetero atom adjacent to the said N and/or methyl substituent(s) on said hetero ring and at least one chlorine atom adjacent to the double bond of the acrylic moiety have been found to have anti-inflammatory properties at reasonably low dosage levels.

Abstract translation: 已经发现，含氮杂环部分的丙烯酰胺任选地在所述杂环上邻近所述N和/或甲基取代基和与丙烯酸部分的双键相邻的至少一个氯原子携带另外的杂原子， 在相当低的剂量水平下具有抗炎性质。

公开(公告)号：US3705902A

公开(公告)日：1972-12-12

申请号：US3705902D

申请日：1971-05-03

Applicant: ABBOTT LAB

Inventor： GARMAISE DAVID LYON ,  PARIS GERARD YVON ,  PLOTNIKOFF NICHOLAS PETER

IPC: C07D471/04 ,  C07D31/44

CPC classification number: C07D471/04

Abstract: 2-ARALKYL-8-FLUORO-1,2,3,4-TETRAHYDRO-5-PROPIONYLPYRIDO(4,3-B)INDOLES HAVE BEEN FOUND TO BE POWERFUL ANTIDEPRESSANTS WHEN ADMINISTERED TO WARM-BLOODED ANIMALS.

公开(公告)号：US3867402A

公开(公告)日：1975-02-18

申请号：US34144473

申请日：1973-03-15

Applicant: ABBOTT LAB

Inventor： PARIS GERARD YVON ,  SWETT LEO RALPH

IPC: C07D231/38 ,  C07D57/02

CPC classification number: C07D231/38 ,  Y10S514/825

Abstract: 1-Methyl-4,5-di(p-methoxyphenyl)-6H-pyrrolo (2,3-c)pyrazole, which is useful as an anti-inflammatory agent, as well as methods for preparing the compound.

Abstract translation: 可用作抗炎剂的1-甲基-4,5-二（对甲氧基苯基）-6H-吡咯并[2,3-c]吡唑，以及制备该化合物的方法。

公开(公告)号：US3701785A

公开(公告)日：1972-10-31

申请号：US3701785D

申请日：1971-02-04

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  PARIS GERARD YVON

IPC: C07D231/38 ,  C07D57/02

CPC classification number: C07D231/38 ,  Y10S514/916

Abstract: 1,3-DIMETHYL-4,6-DI(P-SUBSTITUTED PHENYL)-6H-PYRROLO(2,3-C)PYRAZOLES AND NOVEL INTERMEDIATES USEFUL IN THEIR SYNTHESIS. THE COMPOUNDS ARE USEFUL AS ANTI-INFLAMMATORY AND ANTI-PYRETIC AGENTS.