公开(公告)号：US3855203A

公开(公告)日：1974-12-17

申请号：US35698773

申请日：1973-05-03

Applicant: ABBOTT LAB

Inventor： HALLAS R ,  TADANIER J ,  VON ESCH A

IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: Covers 4''''-O-sulfonyl erythromycin-9-O-oxime derivatives falling within the following structural formula: WHERE R is selected from the group consisting of loweralkyl, loweralkenyl, aryl, substituted aryl, benzyl and substituted benzyl, R1 is hydrogen or methyl, R2 is hydrogen or loweralkanoyl, R3 is hydrogen or hydroxyl, and R4 is selected from the group consisting of loweralkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, benzyl and substituted benzyl. These 9-O-oxime derivative compounds are useful as antibiotics.

Abstract translation: 涵盖落在以下结构式中的4“-O-磺酰基红霉素-9-O-肟衍生物：

公开(公告)号：US3818103A

公开(公告)日：1974-06-18

申请号：US29635472

申请日：1972-10-10

Applicant: ABBOTT LAB

Inventor： VON ESCH A ,  GEISZLER A

IPC: A61K31/19 ,  A61K27/00

CPC classification number: A61K31/19 ,  Y10S514/934

Abstract: A method of treating herpes simplex infections in animals by administering sulfonoacetic acid or its salts. Although herpes simplex is a very common though minor disease, the only basic treatment presently available is the application of idoxuridine.

Abstract translation: 一种通过给予磺酰醋酸或其盐治疗动物单纯疱疹感染的方法。

公开(公告)号：US3725424A

公开(公告)日：1973-04-03

申请号：US3725424D

申请日：1970-10-30

Applicant: ABBOTT LAB

Inventor： VON ESCH A ,  CROVETTI A

IPC: C07D413/04 ,  C07D417/14 ,  C07D487/18 ,  C07D31/42

CPC classification number: C07D413/04 ,  C07D417/14

Abstract: New antimicrobial agents of the formula

WHERE R1 includes halophenyl, loweralkyl, phenyl, nitrophenyl, dinitrophenyl, nitrofuryl, and nitrothienyl; R2 includes hydrogen and loweralkyl; and Nhet includes a heterocyclic moiety bonded through a nitrogen thereof which is sufficiently basic to form quaternary ammonium salts.