Patent search ap:("ABBOTT LABORATORIES") AND inv:"Bryan C. Tieman" Page 1

1.

发明授权
Anti-T. cruzi antibodies and methods of use 有权

公开(公告)号：US09482667B2

公开(公告)日：2016-11-01

申请号：US14686351

申请日：2015-04-14

Applicant: Abbott Laboratories

Inventor： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann

IPC: G01N33/53 , C07K16/20 , G01N33/569

CPC classification number: G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00

Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

2.

发明授权
Anti-GP73 monoclonal antibodies and methods of obtaining the same 有权

公开(公告)号：US10308709B2

公开(公告)日：2019-06-04

申请号：US15290762

申请日：2016-10-11

Applicant: ABBOTT LABORATORIES

Inventor： Bailin Tu , Robert N. Ziemann , Bryan C. Tieman , Philip M. Hemken , Carol S. Ramsay , Carolyn J. Strobel , David J. Hawksworth , Larry G. Birkenmeyer , Cheng Zhao , Susan E. Brophy , Barry L. Dowell , Anthony S. Muerhoff

IPC: G01N33/53 , C07K16/18 , G01N33/574 , G01N33/68

Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.

3.

发明申请
ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE 审中-公开

公开(公告)号：US20190162726A1

公开(公告)日：2019-05-30

申请号：US16237106

申请日：2018-12-31

Applicant: Abbott Laboratories

Inventor： David J. Hawksworth , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Susan E. Brophy , Dinesh O. Shah , Joan D. Tyner , Robert N. Ziemann

IPC: G01N33/569 , C07K16/20

Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

4.

发明授权
Anti-GP73 monoclonal antibodies and methods of obtaining the same 有权
Title translation: 抗GP73单克隆抗体和获得相同的方法

公开(公告)号：US09469686B2

公开(公告)日：2016-10-18

申请号：US13836229

申请日：2013-03-15

Applicant: Abbott Laboratories

Inventor： Bailin Tu , Robert N. Ziemann , Bryan C. Tieman , Philip M. Hemken , Carol S. Ramsay , Carolyn J. Strobel , David J. Hawksworth , Larry G. Birkenmeyer , Cheng Zhao , Susan E. Brophy , Barry L. Dowell , Anthony S. Muerhoff

IPC: C07K16/00 , A61K39/395 , C07K16/18 , G01N33/574 , G01N33/68

CPC classification number: C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , G01N33/57438 , G01N33/6893 , G01N2333/47 , G01N2800/085 , G01N2800/50

Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.

Abstract translation: 本文公开了使用所述抗体检测样品中的高尔基体蛋白73（GP73）和岩藻糖基化GP73的抗体和方法。

5.

发明申请
SOLUBLE FMS-LIKE TYROSINE KINASE-1 (sFLT-1) ANTIBODY AND RELATED COMPOSITION, KIT, METHODS OF USING, AND MATERIALS AND METHOD FOR MAKING 审中-公开
Title translation: 可溶性FMS-样酪氨酸激酶-1（sFLT-1）抗体及相关组合物，试剂盒，使用方法，材料和制备方法

公开(公告)号：US20130040407A1

公开(公告)日：2013-02-14

申请号：US13652402

申请日：2012-10-15

Applicant: Abbott Laboratories

Inventor： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan D. Tyner , Zhiguang Yu

IPC: G01N33/577 , G01N33/566

CPC classification number: C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/92

Abstract: An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.

Abstract translation: 特异性结合sFlt-1或其片段的分离的抗体，其具有（i）包含SEQ ID NO：2的氨基酸序列的可变重结构域，（ii）包含SEQ ID NO：2的氨基酸序列的可变轻区域区域 SEQ ID NO：4，或（iii）（i）和（ii）两者，药物组合物和包含这种抗体的试剂盒，制备这种抗体的方法，确定sFlt- 1或其片段，治疗或预防性地需要sFlt-1拮抗剂的方法，分离的核酸，其包含编码（i）SEQ ID NO：1的氨基酸序列的核苷酸序列， 2，（ii）SEQ ID NO：4或（iii）（i）和（ii），任选地作为载体的一部分，以及包含并表达这种核酸的宿主细胞。

6.

发明授权
Anti-T. cruzi antibodies and methods of use 有权

公开(公告)号：US10215754B2

公开(公告)日：2019-02-26

申请号：US15287605

申请日：2016-10-06

Applicant: Abbott Laboratories

Inventor： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann

IPC: C07K16/20 , G01N33/569

Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

7.

发明申请
ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE 有权
Title translation: ANTI-T。 CRUZI抗体和使用方法

公开(公告)号：US20150212083A1

公开(公告)日：2015-07-30

申请号：US14686351

申请日：2015-04-14

Applicant: Abbott Laboratories

Inventor： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann

IPC: G01N33/569 , C07K16/20

CPC classification number: G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00

Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

Abstract translation: 本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。