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1.发明公开公开(公告)号：US20230270151A1
公开(公告)日：2023-08-31
申请号：US18056768
申请日：2022-11-18
Applicant: Abbott Laboratories
Inventor： Paul Johns , Mustafa Vurma , Daniel Albrecht , Stephen DeMichele , Gary Katz , Todime Reddy
IPC: A23L33/115 , A23L33/00 , A23L33/15 , A23C9/152 , A23L33/17 , A23L33/155 , A23L33/19
CPC classification number: A23L33/115 , A23L33/40 , A23L33/15 , A23C9/1528 , A23L33/17 , A23L33/155 , A23L33/19 , A23C9/1526 , A23V2002/00
Abstract: Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.
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公开(公告)号：US09693577B2
公开(公告)日：2017-07-04
申请号：US14043470
申请日：2013-10-01
Applicant: Abbott Laboratories
Inventor： Charles Helmke , Paul Johns , Ann Kensler
CPC classification number: A23L33/10 , A23L3/46 , A23L33/165 , A23L33/40 , A23V2002/00
Abstract: Spray dried nutritional powders include soluble calcium, protein, and at least one of a soluble citrate, a soluble phosphate, and combinations thereof as at least one chelating agent. At least a portion of the soluble calcium is calcium HMB. At least a portion of the protein is soluble protein. The spray dried nutritional powders have a weight ratio of soluble calcium binding capacity to total soluble calcium of from about 2.3:1 to about 12:1. The calcium HMB, the at least one chelating agent, and the protein are spray dried together.
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公开(公告)号：US10058113B2
公开(公告)日：2018-08-28
申请号：US15588950
申请日：2017-05-08
Applicant: ABBOTT LABORATORIES
Inventor： Guarav Patel , Paul Johns , Normanella Dewille , Suzette Pereira
CPC classification number: A23L2/52 , A23L2/46 , A23L2/66 , A23L33/105 , A23L33/17 , A23L33/40 , A23V2002/00 , A23V2200/00 , A61K36/82 , A23V2250/214 , A23V2250/5424 , A23V2250/54244
Abstract: Disclosed herein are shelf-stable, clear liquid nutritional compositions having a pH ranging from 2.5 to 4.6 and comprising water; at least one source of EGCg in an amount sufficient to provide 200-1700 mg/L of EGCg; and at least one source of protein in an amount sufficient to provide 25-45 g/L of total protein. The shelf-stable, clear liquid nutritional compositions lose no more than 20% by weight solids of the EGCg content present in the initial formulation of the compositions to epimerization, degradation, or both epimerization and degradation during heat sterilization. In certain embodiments, the loss of EGCg is exhibited by the amount of epimerization product GCg present in the shelf-stable, clear liquid nutritional composition following heat sterilization. Methods for preparing the shelf-stable, clear liquid nutritional compositions are also disclosed herein.
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公开(公告)号：US20170295836A1
公开(公告)日：2017-10-19
申请号：US15638487
申请日：2017-06-30
Applicant: Abbott Laboratories
Inventor： Charles Helmke , Paul Johns , Ann Kensler
IPC: A23L33/10 , A23L33/165 , A23L33/40 , A23L3/46
CPC classification number: A23L33/10 , A23L3/46 , A23L33/165 , A23L33/40 , A23V2002/00
Abstract: Spray dried nutritional powders include soluble calcium, protein, and at least one of a soluble citrate, a soluble phosphate, and combinations thereof as at least one chelating agent. At least a portion of the soluble calcium is calcium HMB. At least a portion of the protein is soluble protein. The spray dried nutritional powders have a weight ratio of soluble calcium binding capacity to total soluble calcium of from about 2.3:1 to about 12:1. The calcium HMB, the at least one chelating agent, and the protein are spray dried together.
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5.发明申请SHELF-STABLE, CLEAR LIQUID NUTRITIONAL COMPOSITIONS COMPRISING EPIGALLOCATECHIN GALLATE (EGCG) AND METHODS FOR PREPARING THE SAME 有权包含EPIGOCOCCHIN GALLATE（EGCG）的清晰液体营养组合物及其制备方法公开(公告)号：US20150250221A1
公开(公告)日：2015-09-10
申请号：US14432015
申请日：2013-10-04
Applicant: ABBOTT LABORATORIES
Inventor： Gaurav Patel , Paul Johns , Normanella Dewille , Suzette Pereira
CPC classification number: A23L2/52 , A23L2/46 , A23L2/66 , A23L33/105 , A23L33/17 , A23L33/40 , A23V2002/00 , A23V2200/00 , A61K36/82 , A23V2250/214 , A23V2250/5424 , A23V2250/54244
Abstract: Disclosed herein are shelf-stable, clear liquid nutritional compositions having a pH ranging from 2.5 to 4.6 and comprising water; at least one source of EGCg in an amount sufficient to provide 200-1700 mg/L of EGCg; and at least one source of protein in an amount sufficient to provide 25-45 g/L of total protein. The shelf-stable, clear liquid nutritional compositions lose no more than 20% by weight solids of the EGCg content present in the initial formulation of the compositions to epimerization, degradation, or both epimerization and degradation during heat sterilization. In certain embodiments, the loss of EGCg is exhibited by the amount of epimerization product GCg present in the shelf-stable, clear liquid nutritional composition following heat sterilization. Methods for preparing the shelf-stable, clear liquid nutritional compositions are also disclosed herein.
Abstract translation: 本文公开了具有pH范围为2.5至4.6并且包含水的储存稳定的透明液体营养组合物; 至少一种EGCg来源，其量足以提供200-1700mg / L的EGCg; 和至少一种蛋白质来源，其量足以提供25-45g / L的总蛋白质。 货架稳定，透明的液体营养组合物在组合物的初始配方中不超过20重量％固体的EGCg含量，在加热灭菌期间差向异构化，降解或差向异构化和降解均失去。 在某些实施方案中，EGCg的损失由加热灭菌后储存稳定的透明液体营养组合物中存在的差向异构化产物GCg的量显示。 制备储存稳定的透明液体营养组合物的方法也在本文中公开。
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Patent Agency Ranking
公开(公告)号：US10772889B2
公开(公告)日：2020-09-15
申请号：US16061522
申请日：2016-12-19
Applicant: Abbott Laboratories
Inventor： Paul Johns , Jeffrey Baxter , Megan Terp , Normanella Dewille , Youngsuk Heo
IPC: A61K31/519 , A23L33/19 , A23L33/175 , A23L33/115 , A23L33/16 , A23L33/125 , A23L33/15 , A23L33/185 , A23L33/00 , A61K47/44
Abstract: A liquid nutritional composition including 5-methyltetrahydrofolic acid (5-MTHF) is provided. The liquid nutritional composition also includes ascorbic acid and a protein system containing methionine to inhibit or reduce oxidation of the 5-MTHF and provide an active folate level of the liquid nutritional composition that remains stable over the shelf life of the liquid nutritional composition.
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公开(公告)号：US20160037817A1
公开(公告)日：2016-02-11
申请号：US14774526
申请日：2014-02-28
Applicant: ABBOTT LABORATORIES
Inventor： Paul Johns , Steven Dimler , Mustafa Vurma
CPC classification number: A23L33/40 , A23L33/16 , A23L33/17 , A23V2002/00 , A23V2200/244 , A23V2250/1578 , A23V2250/1618 , A23V2250/54
Abstract: A nutritional composition comprising at least one protein, at least one macronutrient other than the at least one protein, and micronized calcium phosphate. The micronized calcium phosphate has a median particle size from about 0.20 to about 1.20 micrometers and may modify the viscosity of the nutritional composition. The micronization of the calcium phosphate may provide for increased bioavailability of calcium and phosphate and protein stability in the nutritional composition.
Abstract translation: 包含至少一种蛋白质，至少一种除了至少一种蛋白质以外的大量营养素和微粉化磷酸钙的营养组合物。 微粉化磷酸钙具有约0.20至约1.20微米的中值粒度，并可改变营养组合物的粘度。 磷酸钙的微粉化可提供营养组合物中钙和磷酸盐的增加的生物利用度和蛋白质的稳定性。
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8.发明申请公开(公告)号：US20230114071A1
公开(公告)日：2023-04-13
申请号：US17964609
申请日：2022-10-12
Applicant: Abbott Laboratories
Inventor： Paul Johns , Mustafa Vurma , Daniel Albrecht , Stephen DeMichele , Gary Katz , Todime Reddy
IPC: A23L33/115 , A23L33/00 , A23L33/15 , A23C9/152 , A23L33/17 , A23L33/155 , A23L33/19
Abstract: Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.
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公开(公告)号：US09675097B2
公开(公告)日：2017-06-13
申请号：US14432015
申请日：2013-10-04
Applicant: ABBOTT LABORATORIES
Inventor： Gaurav Patel , Paul Johns , Normanella Dewille , Suzette Pereira
CPC classification number: A23L2/52 , A23L2/46 , A23L2/66 , A23L33/105 , A23L33/17 , A23L33/40 , A23V2002/00 , A23V2200/00 , A61K36/82 , A23V2250/214 , A23V2250/5424 , A23V2250/54244
Abstract: Disclosed herein are shelf-stable, clear liquid nutritional compositions having a pH ranging from 2.5 to 4.6 and comprising water; at least one source of EGCg in an amount sufficient to provide 200-1700 mg/L of EGCg; and at least one source of protein in an amount sufficient to provide 25-45 g/L of total protein. The shelf-stable, clear liquid nutritional compositions lose no more than 20% by weight solids of the EGCg content present in the initial formulation of the compositions to epimerization, degradation, or both epimerization and degradation during heat sterilization. In certain embodiments, the loss of EGCg is exhibited by the amount of epimerization product GCg present in the shelf-stable, clear liquid nutritional composition following heat sterilization. Methods for preparing the shelf-stable, clear liquid nutritional compositions are also disclosed herein.
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10.发明申请STERILIZED LIQUID PROTEIN SUPPLEMENT INCLUDING A SOLUBILITY ENHANCING NUTRITIONAL PROTEIN 审中-公开无菌液体蛋白质补充剂，包括可溶性增强营养蛋白公开(公告)号：US20150110919A1
公开(公告)日：2015-04-23
申请号：US14402614
申请日：2013-05-23
Applicant: ABBOTT LABORATORIES
Inventor： Paul Johns , Steven Luebbers , Kandice Tucker
CPC classification number: A23L33/40 , A23C2240/15 , A23L2/66 , A23L3/3526 , A23L33/18 , A23L33/19 , A23V2002/00 , A23V2200/316 , A23V2250/54246 , A23V2250/54252 , A23V2250/5488
Abstract: Disclosed are substantially stable sterilized liquid protein supplements including a highly soluble protein source for use with human milk and other infant or adult feeding formulas. The sterilized liquid protein supplements have a more neutral pH, thereby inhibiting protein denaturation and reducing microbial growth. In one aspect, the sterilized liquid protein supplement comprises at least 250 mg of protein per 1 ml, the protein has a degree of hydrolysis of 25% to 45%, a molecular weight median of less than 800 Daltons, and a dipeptide and tripeptide concentration of no more than 40% by weight total protein, wherein the sterilized liquid protein supplement has a pH of 3 to 8.
Abstract translation: 公开了基本上稳定的灭菌液体蛋白质补充剂，包括用于人乳和其他婴儿或成人饲料配方的高度可溶性蛋白质来源。 无菌液体蛋白质补充剂具有更中性的pH值，从而抑制蛋白质变性和减少微生物生长。 一方面，无菌液体蛋白质补充剂每1ml含有至少250mg的蛋白质，蛋白质的水解度为25％至45％，分子量中值小于800道尔顿，二肽和三肽浓度 不超过40重量％的总蛋白质，其中无菌液体蛋白质补充剂的pH为3至8。
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