公开(公告)号：US20170327803A1

公开(公告)日：2017-11-16

申请号：US15662173

申请日：2017-07-27

Applicant: Abbott Laboratories

Inventor： A. Scott Muerhoff ,  Christopher Marohnic ,  Larry Birkenmeyer ,  John Prostko ,  M. Felicia Bogdan ,  Robin Gutierrez

IPC: C12N9/14 ,  G01N33/576 ,  C07K14/005

CPC classification number: C12N9/14 ,  C07K14/005 ,  C07K2319/20 ,  C07K2319/21 ,  C12N2770/24222 ,  C12N2800/22 ,  G01N33/5767 ,  G01N2469/20

Abstract: The present disclosure relates to polypeptides, including fusions thereof, nucleic acids, vectors, host cells, immunodiagnostic reagents, kits, and immunoassays for use detecting the presence of HCV antibodies. More specifically, the present invention describes specific NS3 antigens that can be used for the detection of anti-HCV antibodies.

公开(公告)号：US20200256843A1

公开(公告)日：2020-08-13

申请号：US16864672

申请日：2020-05-01

Applicant: ABBOTT LABORATORIES

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew S. Schapals ,  Anthony S. Muerhoff ,  M. Felicia Bogdan ,  Thomas Leary ,  Shelley R. Holets-McCormack ,  Sophie Laurenson ,  Andrew T. Fischer ,  Richard Haack ,  Stefan Hershberger ,  Dustin House ,  Lei Qiao ,  M. Shawn Murphy ,  Mark R. Pope ,  Edna M. Prieto-Ballengee ,  QiaoQiao Ruan ,  Pathik Soni ,  Sergey Tetin ,  Lyle Yarnell

IPC: G01N33/487 ,  G01N33/53 ,  B01L3/00 ,  G01N33/543

Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.

公开(公告)号：US09841427B2

公开(公告)日：2017-12-12

申请号：US14851471

申请日：2015-09-11

Applicant: Abbott Laboratories

Inventor： George J. Dawson ,  Suresh M. Desai ,  Robin A. Gutierrez ,  A. Scott Muerhoff ,  John Prostko ,  M. Felicia Bogdan ,  Christopher C. Marohnic

IPC: G01N33/53 ,  G01N33/576 ,  G01N33/543 ,  G01N33/569

CPC classification number: G01N33/5767 ,  G01N33/5306 ,  G01N33/54306 ,  G01N33/56983 ,  G01N2333/186 ,  G01N2333/914 ,  G01N2469/10 ,  G01N2469/20

Abstract: The present invention generally relates to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a test sample.

公开(公告)号：US20240377405A1

公开(公告)日：2024-11-14

申请号：US18761492

申请日：2024-07-02

Applicant: Abbott Laboratories

Inventor： Qiaoqiao Ruan ,  Patrick J. Macdonald ,  Kerry M. Swift ,  Sergey Y. Tetin ,  Brenda Calfin ,  Zhen Lin ,  Richard Haack ,  Mark R. Pope ,  John Prostko ,  Xiaoxing Qiu ,  M. Felicia Bogdan

IPC: G01N33/58 ,  G01N15/10 ,  G01N15/14 ,  G01N33/543

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a cross-linked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：US12061200B2

公开(公告)日：2024-08-13

申请号：US16729067

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： Qiaoqiao Ruan ,  Patrick J. Macdonald ,  Kerry M. Swift ,  Sergey Y. Tetin ,  Brenda Calfin ,  Zhen Lin ,  Richard Haack ,  Mark R. Pope ,  John Prostko ,  Xiaoxing Qiu ,  M. Felicia Bogdan

IPC: G01N33/53 ,  G01N15/14 ,  G01N33/543 ,  G01N33/58 ,  G01N15/10

CPC classification number: G01N33/582 ,  G01N15/14 ,  G01N33/54346 ,  G01N33/587 ,  G01N2015/1018

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a cross-linked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：US11022598B2

公开(公告)日：2021-06-01

申请号：US15724213

申请日：2017-10-03

Applicant: ABBOTT LABORATORIES

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew S. Schapals ,  Anthony S. Muerhoff ,  M. Felicia Bogdan ,  Thomas Leary ,  Shelley R. Holets-McCormack ,  Sophie Laurenson ,  Andrew T. Fischer ,  Richard Haack ,  Stefan Hershberger ,  Dustin House ,  Lei Qiao ,  M. Shawn Murphy ,  Mark R. Pope ,  Edna M. Prieto-Ballengee ,  QiaoQiao Ruan ,  Pathik Soni ,  Sergey Tetin ,  Lyle Yarnell

IPC: G01N33/487 ,  G01N33/543 ,  G01N33/53 ,  B01L3/00

Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.

公开(公告)号：US20170003290A9

公开(公告)日：2017-01-05

申请号：US14851471

申请日：2015-09-11

Applicant: Abbott Laboratories

Inventor： GEORGE J. DAWSON ,  Suresh M. Desai ,  Robin A. Gutierrez ,  A. Scott Muerhoff ,  John Prostko ,  M. Felicia Bogdan ,  Christopher C. Marohnic

IPC: G01N33/576

CPC classification number: G01N33/5767 ,  G01N33/5306 ,  G01N33/54306 ,  G01N33/56983 ,  G01N2333/186 ,  G01N2333/914 ,  G01N2469/10 ,  G01N2469/20

Abstract: The present invention generally relates to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a test sample.

Abstract translation: 本发明一般涉及用于在测试样品中同时检测HCV抗原和抗HCV抗体的组合免疫测定，试剂和试剂盒。