公开(公告)号：US11478796B2

公开(公告)日：2022-10-25

申请号：US16336832

申请日：2017-10-09

Applicant: ACOUSORT AB ,  INSTRUMENTATION LABORATORY COMPANY

Inventor： Per Augustsson ,  Pelle Daniel Ohlsson ,  Ola Jakobsson ,  Klara Andersson ,  Gert Blankenstein ,  Josef Kerimo ,  Ethan Schonbrun

IPC: B01L3/00 ,  G01N1/40 ,  G01N33/49 ,  G01N29/22

Abstract: The invention relates to a method of performing an optical or electrical measurement in a sample of a disperse fluid, the sample comprising particles and a fluid. The method comprises the steps of: a) positioning the sample in a microfluidic cavity having a resonance frequency, b) subjecting the sample, in the cavity, to an acoustic standing wave configured for causing the particles to congregate in at least one first region of the cavity, thereby causing the fluid to occupy at least one second region of the cavity, wherein the frequency of the acoustic standing wave is varied between a frequency below the resonance frequency and a frequency above the resonance frequency, and c) performing an optical or electrical measurement in the fluid in at least one of the at least one second region of the cavity. Varying the frequency ensures reproducible results. The invention also relates to a system therefore and a method and system for measuring hematocrit.

公开(公告)号：US20240226894A1

公开(公告)日：2024-07-11

申请号：US18561921

申请日：2022-05-25

Applicant: ACOUSORT AB

Inventor： Johan Nilsson ,  Klara Andersson

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/50273 ,  B01L2300/0645 ,  B01L2400/0439

Abstract: A method of performing an acoustofluidic operation, comprising the steps of: a. providing (1) an acoustofluidic device (10) comprising:—a substrate (12) in which a microfluidic cavity (30) is positioned, and—at least a first (50a) and a second (50b) ultrasound transducer (50), each provided in acoustic contact with the substrate (12) for transferring ultrasonic vibrations to the substrate and causing the substrate to vibrate, wherein the first and the second ultrasound transducers each comprise a first electrode (52) and a second electrode (56a, 56b) in contact with a piezoelectric or electrostrictive material (54), and wherein the first electrodes are in electric contact with each other, b. providing a fluid, such as a liquid (2) or liquid suspension in the microfluidic cavity (30), c. applying (56a, 56b) of the first and second ultrasound transducers (50a, 50b), wherein the drive signal has a frequency f that corresponds to an acoustic resonance peak of one or more of the substrate, the microfluidic cavity filled with a fluid, and the transducers (50a, 50b), and d. letting the electrical potential of the first electrodes (52) float.