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公开(公告)号：US11478796B2
公开(公告)日：2022-10-25
申请号：US16336832
申请日：2017-10-09
Applicant: ACOUSORT AB , INSTRUMENTATION LABORATORY COMPANY
Inventor： Per Augustsson , Pelle Daniel Ohlsson , Ola Jakobsson , Klara Andersson , Gert Blankenstein , Josef Kerimo , Ethan Schonbrun
Abstract: The invention relates to a method of performing an optical or electrical measurement in a sample of a disperse fluid, the sample comprising particles and a fluid. The method comprises the steps of: a) positioning the sample in a microfluidic cavity having a resonance frequency, b) subjecting the sample, in the cavity, to an acoustic standing wave configured for causing the particles to congregate in at least one first region of the cavity, thereby causing the fluid to occupy at least one second region of the cavity, wherein the frequency of the acoustic standing wave is varied between a frequency below the resonance frequency and a frequency above the resonance frequency, and c) performing an optical or electrical measurement in the fluid in at least one of the at least one second region of the cavity. Varying the frequency ensures reproducible results. The invention also relates to a system therefore and a method and system for measuring hematocrit.
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公开(公告)号：US11331668B2
公开(公告)日：2022-05-17
申请号：US16641421
申请日：2018-08-31
Applicant: ACOUSORT AB
Inventor： Henrik Bruus , Rayisa Moiseyenko , Torsten Freltoft , Pelle Ohlsson , Ola Jakobsson
IPC: B01L3/00
Abstract: The invention relates to a method of performing an acoustophoretic operation, comprising the steps of: a. providing an acoustophoretic chip comprising a polymer substrate in which a microfluidic flow channel is positioned, b. providing at least one ultrasound transducer in acoustic contact with one surface of the substrate, c. actuating the at least one ultrasound transducer at a frequency f that corresponds to an acoustic resonance peak of the substrate including the microfluidic flow channel filled with a liquid suspension, and d. providing the liquid suspension in the flow channel to perform the acoustophoretic operation on the liquid suspension. The invention further relates to an acoustophoretic device, a method of producing an acoustophoretic device, and a microfluidic system comprising the acoustophoretic device.
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公开(公告)号：US20200238280A1
公开(公告)日：2020-07-30
申请号：US16641421
申请日：2018-08-31
Applicant: ACOUSORT AB
Inventor： Henrik Bruus , Rayisa Moiseyenko , Torsten Freltoft , Pelle Ohlsson , Ola Jakobsson
IPC: B01L3/00
Abstract: The invention relates to a method of performing an acoustophoretic operation, comprising the steps of: a. providing an acoustophoretic chip comprising a polymer substrate in which a microfluidic flow channel is positioned, b. providing at least one ultrasound transducer in acoustic contact with one surface of the substrate, c. actuating the at least one ultrasound transducer at a frequency f that corresponds to an acoustic resonance peak of the substrate including the microfluidic flow channel filled with a liquid suspension, and d. providing the liquid suspension in the flow channel to perform the acoustophoretic operation on the liquid suspension. The invention further relates to an acoustophoretic device, a method of producing an acoustophoretic device, and a microfluidic system comprising the acoustophoretic device.
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