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公开(公告)号：US11478796B2
公开(公告)日：2022-10-25
申请号：US16336832
申请日：2017-10-09
Applicant: ACOUSORT AB , INSTRUMENTATION LABORATORY COMPANY
Inventor： Per Augustsson , Pelle Daniel Ohlsson , Ola Jakobsson , Klara Andersson , Gert Blankenstein , Josef Kerimo , Ethan Schonbrun
Abstract: The invention relates to a method of performing an optical or electrical measurement in a sample of a disperse fluid, the sample comprising particles and a fluid. The method comprises the steps of: a) positioning the sample in a microfluidic cavity having a resonance frequency, b) subjecting the sample, in the cavity, to an acoustic standing wave configured for causing the particles to congregate in at least one first region of the cavity, thereby causing the fluid to occupy at least one second region of the cavity, wherein the frequency of the acoustic standing wave is varied between a frequency below the resonance frequency and a frequency above the resonance frequency, and c) performing an optical or electrical measurement in the fluid in at least one of the at least one second region of the cavity. Varying the frequency ensures reproducible results. The invention also relates to a system therefore and a method and system for measuring hematocrit.
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公开(公告)号：US11079325B2
公开(公告)日：2021-08-03
申请号：US14696756
申请日：2015-04-27
Applicant: Instrumentation Laboratory Company
Inventor： Josef Kerimo , Hansong Zeng , Ron Scharlack , Gert Blankenstein
Abstract: This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.
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公开(公告)号：US10648907B2
公开(公告)日：2020-05-12
申请号：US16403180
申请日：2019-05-03
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Lara Adib , Gert Blankenstein
Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.
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4.发明申请公开(公告)号：US20200047183A1
公开(公告)日：2020-02-13
申请号：US16660546
申请日：2019-10-22
Applicant: Instrumentation Laboratory Company
Inventor： Gert Blankenstein , Hansong Zeng
Abstract: Described is an automated reagent dispensing cap and methods of use in an automated clinical analyzer for introducing one or more reagent components housed in the reagent dispensing cap into a container enclosing another reagent component with which it is combined to achieve a reagent useful for diagnostic testing.
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公开(公告)号：US10302559B2
公开(公告)日：2019-05-28
申请号：US16211581
申请日：2018-12-06
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Lara Adib , Gert Blankenstein
Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.
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Patent Agency Ranking
6.发明申请Spatial Separation of Particles in a Particle Containing Solution for Biomedical Sensing and Detection 审中-公开用于生物医学感测和检测的含有颗粒的颗粒的空间分离公开(公告)号：US20160202237A1
公开(公告)日：2016-07-14
申请号：US14992284
申请日：2016-01-11
Applicant: Instrumentation Laboratory Company
Inventor： Hansong Zeng , Gert Blankenstein
CPC classification number: G01N33/49 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/06 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2400/0436 , B01L2400/0439 , G01N1/4077
Abstract: A device and method for analyte detection and analytes in a particulate bearing fluid such as whole blood having an instrument for partitioning the particles from the fluid that is integrated with a detector for analyses of one or more particulate bearing fluid analytes while the particles in the particulate bearing fluid are partitioned.
Abstract translation: 一种用于分析物检测和分析物的装置和方法，其包括诸如全血的颗粒状载体流体，其具有用于将颗粒与流体分隔的仪器，所述仪器与用于分析一种或多种颗粒状载体流体分析物的检测器结合，同时颗粒中的颗粒 轴承流体被分隔。
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公开(公告)号：US20220113293A1
公开(公告)日：2022-04-14
申请号：US17560828
申请日：2021-12-23
Applicant: Instrumentation Laboratory Company
Inventor： Hansong Zeng , Gert Blankenstein
Abstract: A device and method for analyte detection and analytes in a particulate bearing fluid such as whole blood having an instrument for partitioning the panicles from the fluid that is integrated with a detector for analyses of one or more particulate bearing fluid analytes while the particles in the particulate bearing fluid are partitioned.
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8.发明授权公开(公告)号：US10456787B2
公开(公告)日：2019-10-29
申请号：US15234111
申请日：2016-08-11
Applicant: Instrumentation Laboratory Company
Inventor： Gert Blankenstein , Hansong Zeng
Abstract: Described is an automated reagent dispensing cap and methods of use in an automated clinical analyzer for introducing one or more reagent components housed in the reagent dispensing cap into a container enclosing another reagent component with which it is combined to achieve a reagent useful for diagnostic testing.
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9.发明申请公开(公告)号：US20180043363A1
公开(公告)日：2018-02-15
申请号：US15234111
申请日：2016-08-11
Applicant: Instrumentation Laboratory Company
Inventor： Gert Blankenstein , Hansong Zeng
Abstract: Described is an automated reagent dispensing cap and methods of use in an automated clinical analyzer for introducing one or more reagent components housed in the reagent dispensing cap into a container enclosing another reagent component with which it is combined to achieve a reagent useful for diagnostic testing.
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公开(公告)号：US20170336385A1
公开(公告)日：2017-11-23
申请号：US15594827
申请日：2017-05-15
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Gert Blankenstein , Josef Kerimo , Hansong Zeng
CPC classification number: G01N33/49 , B01L3/502 , B01L2300/0654 , B01L2300/168 , G01N21/0303 , G01N21/05 , G01N21/25 , G01N21/552 , G01N2201/0612
Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.
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