公开(公告)号：US20250135670A1

公开(公告)日：2025-05-01

申请号：US18958690

申请日：2024-11-25

Applicant: ACULON, INC.

Inventor： Eric L. Hanson ,  Eric L. Bruner ,  Majid Monji ,  Justin Hardin ,  Edward Hughes ,  Qian He ,  Gloria Zarate

IPC: B26B21/60 ,  C23C22/05

Abstract: Surface-treated cutting blades are provided, comprising: (a) a metal cutting blade body; and (b) a self-assembled monolayer formed from an alkoxysilane and/or organophosphonic acid. The surface-treated cutting blades may further comprise one or more layers formed from chrome, tantalum, titanium, an aqueous solution of a metal salt, and/or an organometallic compound, applied between the cutting blade and the self-assembled monolayer. Also provided is a method of reducing deposition of a contaminant on a surface of metal cutting blade, comprising: (a) contacting the surface either directly or through an intermediate organometallic layer with a fluorinated material in a diluent; (b) forming a film on the surface; and (c) exposing the cutting blade to the contaminant.

公开(公告)号：US20210404594A1

公开(公告)日：2021-12-30

申请号：US17465277

申请日：2021-09-02

Applicant: ACULON, INC.

Inventor： ERIC LEE HANSON ,  Eric L. Bruner ,  Justin Hardin ,  Edward W. Hughes

IPC: F16L58/08 ,  B05D1/18 ,  B82Y40/00 ,  B82Y30/00

Abstract: A surface-treated fluidic channel is provided comprising a dispensing device that comprises a microarray of microchannels. The fluidic channel is made from metal and comprises a surface and a hydrophobic coating layer comprising a self-assembled monolayer of an organophosphorus acid adhered to the surface. A mesh nebulizer comprising a reservoir and a dispensing device comprising a microarray of microchannels is also provided. A metal surface layer is applied to the interior and exterior surfaces of the reservoir and dispensing device, and a hydrophobic coating layer comprising an organo-silicon or a self-assembled monolayer of an organophosphorus acid is adhered to the metal surface layer, usually on the exterior surfaces of the reservoir and dispensing device. A hydrophilic polymeric coating layer may be chemically bonded to and propagated from terminal functional groups on the hydrophobic coating layer on the interior surfaces of the reservoir and dispensing device.

公开(公告)号：US20240189551A1

公开(公告)日：2024-06-13

申请号：US18537706

申请日：2023-12-12

Applicant: ACULON, INC.

Inventor： Eric L. Hanson ,  Justin Hardin ,  Edward Hughes

IPC: A61M25/09 ,  A61L31/02 ,  A61L31/08 ,  A61L31/10

CPC classification number: A61M25/09 ,  A61L31/022 ,  A61L31/082 ,  A61L31/10 ,  A61M2025/09058 ,  A61M2025/09108 ,  A61M2025/09133 ,  A61M2205/0216 ,  A61M2205/0238

Abstract: Coated medical guidewires are provided comprising: (a) a guidewire substrate comprising stainless steel, surgical steel, nitinol, or CoCrMo alloy; and (b) a cured coating layer applied to the guidewire substrate (a). The cured coating layer is prepared from a curable film-forming composition comprising an aqueous solution of sodium silicate. Also provided are methods of forming coated medical guidewires comprising: (a) cleaning a guidewire substrate; (b) contacting the guidewire substrate with a curable film-forming composition comprising an aqueous solution of sodium silicate to form a coating layer on the guidewire; and (c) subjecting the guidewire substrate and film forming composition to a temperature of at least 120° C. for a time sufficient to effect cure and form a coated medical guidewire.

公开(公告)号：US20240142039A1

公开(公告)日：2024-05-02

申请号：US18404578

申请日：2024-01-04

Applicant: ACULON, INC.

Inventor： ERIC LEE HANSON ,  Eric L. Bruner ,  Justin Hardin ,  Edward W. Hughes

IPC: F16L58/08 ,  B05D1/18 ,  B05D7/00 ,  B05D7/22 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: F16L58/08 ,  B05D1/185 ,  B05D7/225 ,  B05D7/544 ,  B82Y30/00 ,  B82Y40/00 ,  B05D7/222 ,  B05D2201/02 ,  B05D2202/00 ,  B05D2254/04

Abstract: A surface-treated fluidic channel is provided comprising a dispensing device that comprises a microarray of microchannels. The fluidic channel is made from metal and comprises a surface and a hydrophobic coating layer comprising a self-assembled monolayer of an organophosphorus acid adhered to the surface. A mesh nebulizer comprising a reservoir and a dispensing device comprising a microarray of microchannels is also provided. A metal surface layer is applied to the interior and exterior surfaces of the reservoir and dispensing device, and a hydrophobic coating layer comprising an organo-silicon or a self-assembled monolayer of an organophosphorus acid is adhered to the metal surface layer, usually on the exterior surfaces of the reservoir and dispensing device. A hydrophilic polymeric coating layer may be chemically bonded to and propagated from terminal functional groups on the hydrophobic coating layer on the interior surfaces of the reservoir and dispensing device.

公开(公告)号：US11867342B2

公开(公告)日：2024-01-09

申请号：US17465277

申请日：2021-09-02

Applicant: ACULON, INC.

Inventor： Eric Lee Hanson ,  Eric L. Bruner ,  Justin Hardin ,  Edward W. Hughes

IPC: F16L58/08 ,  B05D1/18 ,  B82Y40/00 ,  B82Y30/00 ,  B05D7/22 ,  B05D5/08

CPC classification number: F16L58/08 ,  B05D1/185 ,  B05D5/08 ,  B05D7/22 ,  B82Y30/00 ,  B82Y40/00 ,  B05D2202/00 ,  B05D2350/65

Abstract: A surface-treated fluidic channel is provided comprising a dispensing device that comprises a microarray of microchannels. The fluidic channel is made from metal and comprises a surface and a hydrophobic coating layer comprising a self-assembled monolayer of an organophosphorus acid adhered to the surface. A mesh nebulizer comprising a reservoir and a dispensing device comprising a microarray of microchannels is also provided. A metal surface layer is applied to the interior and exterior surfaces of the reservoir and dispensing device, and a hydrophobic coating layer comprising an organo-silicon or a self-assembled monolayer of an organophosphorus acid is adhered to the metal surface layer, usually on the exterior surfaces of the reservoir and dispensing device. A hydrophilic polymeric coating layer may be chemically bonded to and propagated from terminal functional groups on the hydrophobic coating layer on the interior surfaces of the reservoir and dispensing device.

公开(公告)号：US20230226261A1

公开(公告)日：2023-07-20

申请号：US18116606

申请日：2023-03-02

Applicant: ACULON, INC.

Inventor： ERIC LEE HANSON ,  Eric L. Bruner ,  Justin Hardin ,  Edward W. Hughes

IPC: A61L31/08 ,  C23C14/34 ,  C23C14/30 ,  C23C14/58 ,  C23C14/14 ,  A61M11/00 ,  A61L31/10

CPC classification number: A61L31/086 ,  C23C14/34 ,  C23C14/30 ,  C23C14/584 ,  C23C14/5873 ,  C23C14/14 ,  A61M11/003 ,  A61L31/10 ,  A61M2205/0238

Abstract: Methods of altering the surface energy of components of a mesh nebulizer are provided, comprising:



a) depositing a metal surface layer on surfaces of the component;
b) forming a hydrophobic coating layer comprising an organo-silicon or a self-assembled monolayer of an organophosphorus acid directly on the metal surface layer or indirectly on the metal surface layer through an intermediate organometallic coating; and either:
i) removing select areas of the hydrophobic coating layer to expose the metal surface layer; or
ii) forming a polymeric coating layer chemically bonded to and propagated from terminal functional groups on the hydrophobic coating layer that are capable of initiating polymer growth when exposed to a source of polymerizable monomer, on select areas of the components. Mesh nebulizers formed by such methods are also provided.