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公开(公告)号：US20240241095A1
公开(公告)日：2024-07-18
申请号：US18503722
申请日：2023-11-07
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： David Long , Chenchen He , Sandeep Kondaveeti , Ta-Chen Wei , Amanda Mcquay
CPC classification number: G01N30/88 , B01D15/10 , B01J20/28004 , B01J20/28083 , B01J20/286 , B01J20/3092 , G01N30/6052 , G01N2030/884 , G01N2030/8872
Abstract: A chromatographic separation column for characterizing surfactant purity is disclosed. The column includes a separation medium having a particulate porous substrate with monofunctional silane with diisopropyl side chain groups and a pendant cyano functional group held within a column. The porous substrate has a pore size of about 50 Å to about 500 Å and an average particle size of about 1.0 μm to about 100 μm. The column has an inner diameter of about 1.0 to 100 mm, e.g., 4.6 mm and a length from about 10 mm to about 250 mm. Methods of facilitating characterization of polysorbate 80 by providing a sample containing polysorbate 80 and one or more reaction products of polysorbate 80 and a chromatographic separation column are disclosed. Methods of characterizing polysorbate 80 by separating polysorbate 80 and one or more reaction products of polysorbate 80 are also disclosed.
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公开(公告)号：US20170349612A1
公开(公告)日：2017-12-07
申请号：US15173382
申请日：2016-06-03
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Wu Chen , Yingyu Li , Ta-Chen Wei , Xiaoli Wang
CPC classification number: C07F7/1804 , B01D15/325 , B01J20/22 , B01J20/28016 , B01J20/283 , C01B33/12 , C07F7/0838 , C07F7/0876 , C07F7/1892
Abstract: Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a siloxane-linked hydrophilic group, such as a charged functional group or a polar neutral functional group. The modified silica particles can form the basis of a variety of chromatography support materials. Also provided are methods of preparing the subject particles. Aspects of the methods include contacting silica particles with water, an ionic fluoride and an organosilane reagent comprising a hydrophilic moiety to produce modified silica particles wherein the hydrophilic moiety of the organosilane reagent is incorporated into an outer layer of the silica particles. Chromatography supports and kits including the subject particles and methods of using the same are also provided.
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公开(公告)号：US10434496B2
公开(公告)日：2019-10-08
申请号：US15084194
申请日：2016-03-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Ta-Chen Wei , Xiaoli Wang
IPC: B01J20/283 , B01J20/28 , B01D15/20
Abstract: Superficially porous particles are provided. Aspects of the superficially porous particles include a non-porous inner core and a porous outer shell that includes inner and outer porous regions. The inner porous region can include ordered cylindrical pores substantially perpendicular to the non-porous inner core. The outer porous region can include conical pores which extend to the surface of the particles and which are in fluid communication with the cylindrical pores of the inner porous region. Also provided are methods of making the subject superficially porous particles. Aspects of the methods include subjecting substantially solid inorganic oxide particles to agitation in an aqueous solution in the presence of a first cationic surfactant and a second anionic surfactant, which together form micelles, to pseudomorphically transform the particles.
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4.发明申请Superficially Porous Hybrid Monoliths with Ordered Pores and Methods of Making and using same 审中-公开具有有序孔的表面多孔混合单晶及其制造和使用方法公开(公告)号：US20150306587A1
公开(公告)日：2015-10-29
申请号：US14442988
申请日：2013-09-27
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Ta-Chen Wei , William E. Barber , Kunqiang Jiang
CPC classification number: B01J31/0201 , B01J20/103 , B01J20/22 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28083 , B01J20/28085 , B01J20/28088 , B01J20/283 , B01J20/3078 , B01J35/1009 , B01J35/1014 , B01J35/1019 , B01J35/1061 , B01J35/108 , B01J37/08 , C01B37/005 , C01B37/02 , C04B35/14 , C04B38/00 , C04B2111/0081 , C04B2235/483 , C04B38/0645
Abstract: The invention provides superficially porous metal oxide or hybrid metal oxide monoliths with ordered pore structures. The superficially porous hybrid silica monoliths of the invention provide several major advantages over existing silica monoliths. When used in chromatography, the superficially porous hybrid silica monoliths of the invention deliver fast separation at very low back pressure and possess superb pH stability and much improved mechanical strength.
Abstract translation: 本发明提供具有有序孔结构的表面多孔金属氧化物或混合金属氧化物整料。 本发明的表面多孔的混合二极石整体提供了优于现有二氧化硅整料的几个主要优点。 当用于色谱法时，本发明的表面多孔混合二氧化硅整体在非常低的背压下提供快速分离并且具有极好的pH稳定性和大大提高的机械强度。
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Patent Agency Ranking
公开(公告)号：US11964874B2
公开(公告)日：2024-04-23
申请号：US17234352
申请日：2021-04-19
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Ta-Chen Wei
CPC classification number: C01B33/18 , B01J20/28016 , B01J20/28021 , C09C1/3045 , C09C1/3072 , C09C1/309 , C01P2004/61 , C01P2004/62 , C01P2006/12 , C01P2006/14
Abstract: There is disclosed a method of producing etched non-porous particles. The method includes, in some examples, coating a non-porous particle with a hydrophilic polymer and treating the coated particle with acid or base. Also provided is etched non-porous particles capable of separating a variety of analytes, including biomolecules.
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6.发明申请Superficially Porous Particles with Precisely Controlled Particle Density, and Methods of Preparation and Use Thereof 审中-公开具有精确控制粒子密度的表面多孔粒子及其制备和使用方法公开(公告)号：US20160136542A1
公开(公告)日：2016-05-19
申请号：US14898013
申请日：2014-06-01
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Ta-Chen Wei
IPC: B01D15/20
CPC classification number: B01D15/20 , B01D15/206 , B01J20/103 , B01J20/28004 , B01J20/28011 , B01J20/28016 , B01J20/28019 , B01J20/28021 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28069 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/2808 , B01J20/28083 , B01J20/28085 , B01J20/283 , B01J20/284 , B01J20/3057 , B01J20/3078
Abstract: The invention provides superficially porous metal oxide particles with precisely controlled particle density and to methods for their preparation and use, as well as to separation devices (e.g., high pressure liquid chromatography) having superficially porous particles.
Abstract translation: 本发明提供具有精确控制的颗粒密度的表面多孔金属氧化物颗粒及其制备和使用方法，以及具有表面多孔颗粒的分离装置（例如，高压液相色谱）。
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公开(公告)号：US10507408B2
公开(公告)日：2019-12-17
申请号：US14898013
申请日：2014-06-01
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Ta-Chen Wei
IPC: B01D15/20 , B01J20/10 , B01J20/28 , B01J20/283 , B01J20/284 , B01J20/30
Abstract: The invention provides superficially porous metal oxide particles with precisely controlled particle density and to methods for their preparation and use, as well as to separation devices (e.g., high pressure liquid chromatography) having superficially porous particles.
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8.发明申请公开(公告)号：US20170282155A1
公开(公告)日：2017-10-05
申请号：US15084194
申请日：2016-03-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Ta-Chen Wei , Xiaoli Wang
IPC: B01J20/283 , B01J20/28 , B01D15/20
CPC classification number: B01J20/283 , B01D15/206 , B01J20/2808 , B01J20/28083 , B01J20/28085
Abstract: Superficially porous particles are provided. Aspects of the superficially porous particles include a non-porous inner core and a porous outer shell that includes inner and outer porous regions. The inner porous region can include ordered cylindrical pores substantially perpendicular to the non-porous inner core. The outer porous region can include conical pores which extend to the surface of the particles and which are in fluid communication with the cylindrical pores of the inner porous region. Also provided are methods of making the subject superficially porous particles. Aspects of the methods include subjecting substantially solid inorganic oxide particles to agitation in an aqueous solution in the presence of a first cationic surfactant and a second anionic surfactant, which together form micelles, to pseudomorphically transform the particles.
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9.发明申请Inorganic/Organic Hybrid Totally Porous Metal Oxide Particles, Methods For Making Them And Separation Devices Using Them 有权无机/有机混合全多孔金属氧化物颗粒，使用它们的分离装置的方法公开(公告)号：US20130102459A1
公开(公告)日：2013-04-25
申请号：US13712597
申请日：2012-12-12
Applicant: Agilent Technologies, Inc.
Inventor： Ta-Chen Wei , Wu Chen , William E. Barber
IPC: B01J20/283
CPC classification number: B01J20/06 , B01J20/00 , B01J20/223 , B01J20/282 , B01J20/283 , B01J20/284 , B01J20/286 , B01J20/3244 , B01J20/3257 , C01B33/00 , C01G23/00 , C01G25/02
Abstract: The present invention is a process for making an inorganic/organic hybrid totally porous spherical silica particles by self assembly of surfactants that serve as organic templates via pseudomorphic transformation.
Abstract translation: 本发明是一种通过自组装用于通过假晶型转化作为有机模板的表面活性剂制备无机/有机杂化全多孔球形二氧化硅颗粒的方法。
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