公开(公告)号：US20170349612A1

公开(公告)日：2017-12-07

申请号：US15173382

申请日：2016-06-03

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Wu Chen ,  Yingyu Li ,  Ta-Chen Wei ,  Xiaoli Wang

IPC: C07F7/18 ,  B01D15/32 ,  C01B33/12 ,  B01J20/28 ,  B01J20/22 ,  C07F7/08 ,  B01J20/283

CPC classification number: C07F7/1804 ,  B01D15/325 ,  B01J20/22 ,  B01J20/28016 ,  B01J20/283 ,  C01B33/12 ,  C07F7/0838 ,  C07F7/0876 ,  C07F7/1892

Abstract: Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a siloxane-linked hydrophilic group, such as a charged functional group or a polar neutral functional group. The modified silica particles can form the basis of a variety of chromatography support materials. Also provided are methods of preparing the subject particles. Aspects of the methods include contacting silica particles with water, an ionic fluoride and an organosilane reagent comprising a hydrophilic moiety to produce modified silica particles wherein the hydrophilic moiety of the organosilane reagent is incorporated into an outer layer of the silica particles. Chromatography supports and kits including the subject particles and methods of using the same are also provided.

公开(公告)号：US20130102459A1

公开(公告)日：2013-04-25

申请号：US13712597

申请日：2012-12-12

Applicant: Agilent Technologies, Inc.

Inventor： Ta-Chen Wei ,  Wu Chen ,  William E. Barber

IPC: B01J20/283

CPC classification number: B01J20/06 ,  B01J20/00 ,  B01J20/223 ,  B01J20/282 ,  B01J20/283 ,  B01J20/284 ,  B01J20/286 ,  B01J20/3244 ,  B01J20/3257 ,  C01B33/00 ,  C01G23/00 ,  C01G25/02

Abstract: The present invention is a process for making an inorganic/organic hybrid totally porous spherical silica particles by self assembly of surfactants that serve as organic templates via pseudomorphic transformation.

Abstract translation: 本发明是一种通过自组装用于通过假晶型转化作为有机模板的表面活性剂制备无机/有机杂化全多孔球形二氧化硅颗粒的方法。