公开(公告)号：US20160347718A1

公开(公告)日：2016-12-01

申请号：US15116861

申请日：2015-02-06

Applicant: API CORPORATION

Inventor： Naoyuki WATANABE ,  Yasumasa DEKISHIMA ,  Masaki NAGAHAMA ,  Tomoko MAEDA ,  Takashi OHTANI ,  Kosuke ITO ,  Hiroshi KAWABATA

IPC: C07D239/42 ,  C12P17/12

CPC classification number: C07D239/42 ,  C12N9/0006 ,  C12P17/12

Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.

Abstract translation: 本发明的目的是提供能够高效，低成本且高纯度地生产瑞舒伐他汀钙及其中间体的新方法。 本发明提供了在不使用极低温反应或特殊的不对称催化剂的情况下，有效地生产工业规模的高纯度的瑞舒伐他汀钙及其中间体的方法。

公开(公告)号：US20240360086A1

公开(公告)日：2024-10-31

申请号：US18750537

申请日：2024-06-21

Applicant: API CORPORATION

Inventor： Tomoko MAEDA ,  Yasumasa DEKISHIMA ,  Hiroshi KAWABATA ,  Masaki NAGAHAMA ,  Naoyuki WATANABE ,  Kosuke ITO

IPC: C07D239/42 ,  C12N9/04 ,  C12P17/12

CPC classification number: C07D239/42 ,  C12N9/0006 ,  C12P17/12 ,  C12Y101/01184

Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.

公开(公告)号：US20170305867A1

公开(公告)日：2017-10-26

申请号：US15600196

申请日：2017-05-19

Applicant: API CORPORATION

Inventor： Naoyuki WATANABE ,  Tomoko MAEDA ,  Yasumasa DEKISHIMA ,  Hiroshi KAWABATA ,  Masaki NAGAHAMA ,  Kosuke ITO

IPC: C07D239/42 ,  C12P17/12 ,  C12N9/04

CPC classification number: C07D239/42 ,  C12N9/0006 ,  C12P17/12 ,  C12Y101/01184

Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.