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1.发明申请公开(公告)号：US20160347718A1
公开(公告)日：2016-12-01
申请号：US15116861
申请日：2015-02-06
Applicant: API CORPORATION
Inventor： Naoyuki WATANABE , Yasumasa DEKISHIMA , Masaki NAGAHAMA , Tomoko MAEDA , Takashi OHTANI , Kosuke ITO , Hiroshi KAWABATA
IPC: C07D239/42 , C12P17/12
CPC classification number: C07D239/42 , C12N9/0006 , C12P17/12
Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
Abstract translation: 本发明的目的是提供能够高效，低成本且高纯度地生产瑞舒伐他汀钙及其中间体的新方法。 本发明提供了在不使用极低温反应或特殊的不对称催化剂的情况下，有效地生产工业规模的高纯度的瑞舒伐他汀钙及其中间体的方法。
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Patent Agency Ranking
公开(公告)号：US20190315696A1
公开(公告)日：2019-10-17
申请号：US16442770
申请日：2019-06-17
Applicant: API CORPORATION
Inventor： Naoyuki WATANABE , Tomoko MAEDA , Yasumasa DEKISHIMA , Hiroshi KAWABATA , Masaki NAGAHAMA
IPC: C07D239/42 , C12N9/04 , C12P17/12
Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
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公开(公告)号：US20230025343A1
公开(公告)日：2023-01-26
申请号：US17778712
申请日：2020-11-20
Applicant: API CORPORATION
Inventor： Takanobu IURA , Yasumasa DEKISHIMA , Takeshi SAKAMOTO , Mari HARA , Hirotoshi HIRAOKA , Harald GRÖGER , Jieun CHOI
Abstract: The present invention provides a carbonyl reductase having the activity of reducing a carbonyl group-containing compound to convert the compound into an optically active compound, and a production method of an optically active compound using the enzyme. Specifically, a carbonyl reductase having one or more mutations in which the 54th aspartic acid, the 157th methionine, the 170th alanine, the 211th isoleucine, the 214th methionine, and the 249th methionine are each substituted by other specific amino acid in the amino acid sequence shown in SEQ ID NO: 1 or a homologue of the amino acid sequence, and a production method of an optically active compound using the same are provided.
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公开(公告)号：US20240360086A1
公开(公告)日：2024-10-31
申请号：US18750537
申请日：2024-06-21
Applicant: API CORPORATION
Inventor： Tomoko MAEDA , Yasumasa DEKISHIMA , Hiroshi KAWABATA , Masaki NAGAHAMA , Naoyuki WATANABE , Kosuke ITO
IPC: C07D239/42 , C12N9/04 , C12P17/12
CPC classification number: C07D239/42 , C12N9/0006 , C12P17/12 , C12Y101/01184
Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
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公开(公告)号：US20170306367A1
公开(公告)日：2017-10-26
申请号：US15526031
申请日：2015-11-02
Applicant: API CORPORATION
Inventor： Ryoma MIYAKE , Yasumasa DEKISHIMA
CPC classification number: C12P17/12 , C12N9/0071 , C12N15/09 , C12Y114/11
Abstract: A method for producing cis-5-hydroxy-L-pipecolic acid, the method comprising allowing a 2-oxoglutarate-dependent L-pipecolic acid hydroxylase to act on L-pipecolic acid to generate cis-5-hydroxy-L-pipecolic acid, wherein the 2-oxoglutarate-dependent L-pipecolic acid hydroxylase comprises the polypeptide (A), (B) or (C) below: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 4 or 11; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 4 or 11 except that one or several amino acids are deleted, substituted, and/or added, which polypeptide has 2-oxoglutarate-dependentL-pipecolic acid hydroxylase activity; or (C) a polypeptide comprising an amino acid sequence with an identity of not less than 60% to the amino acid sequence represented by SEQ ID NO: 4 or 11, which polypeptide has 2-oxoglutarate-dependent L-pipecolic acid hydroxylase activity.
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公开(公告)号：US20170305867A1
公开(公告)日：2017-10-26
申请号：US15600196
申请日：2017-05-19
Applicant: API CORPORATION
Inventor： Naoyuki WATANABE , Tomoko MAEDA , Yasumasa DEKISHIMA , Hiroshi KAWABATA , Masaki NAGAHAMA , Kosuke ITO
IPC: C07D239/42 , C12P17/12 , C12N9/04
CPC classification number: C07D239/42 , C12N9/0006 , C12P17/12 , C12Y101/01184
Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
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