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    ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF
    4.
    发明申请
    ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF 有权
    ROSUVASTATIN钙及其生产中间体的方法

    公开(公告)号：US20160347718A1

    公开(公告)日：2016-12-01

    申请号：US15116861

    申请日：2015-02-06

    Applicant: API CORPORATION

    Inventor： Naoyuki WATANABE ,  Yasumasa DEKISHIMA ,  Masaki NAGAHAMA ,  Tomoko MAEDA ,  Takashi OHTANI ,  Kosuke ITO ,  Hiroshi KAWABATA

    IPC: C07D239/42 ,  C12P17/12

    CPC classification number: C07D239/42 ,  C12N9/0006 ,  C12P17/12

    Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.

    Abstract translation: 本发明的目的是提供能够高效，低成本且高纯度地生产瑞舒伐他汀钙及其中间体的新方法。 本发明提供了在不使用极低温反应或特殊的不对称催化剂的情况下，有效地生产工业规模的高纯度的瑞舒伐他汀钙及其中间体的方法。

    METHOD FOR PRODUCING HYDROXY-L-PIPECOLIC ACID
    5.
    发明申请
    METHOD FOR PRODUCING HYDROXY-L-PIPECOLIC ACID 有权

    公开(公告)号：US20210180097A1

    公开(公告)日：2021-06-17

    申请号：US17177823

    申请日：2021-02-17

    Applicant: API CORPORATION

    Inventor： Ryoma MIYAKE ,  Hiroshi KAWABATA

    IPC: C12P17/12 ,  C12N9/10 ,  C12N9/06 ,  C12N9/02

    Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.

    METHOD FOR PRODUCING HYDROXY-L-PIPECOLIC ACID
    6.
    发明申请
    METHOD FOR PRODUCING HYDROXY-L-PIPECOLIC ACID 审中-公开

    公开(公告)号：US20180273993A1

    公开(公告)日：2018-09-27

    申请号：US15765148

    申请日：2016-09-30

    Applicant: API CORPORATION

    Inventor： Ryoma MIYAKE ,  Hiroshi KAWABATA

    IPC: C12P17/12

    CPC classification number: C12P17/12 ,  C12N9/0016 ,  C12N9/0022 ,  C12N9/0071 ,  C12N9/1096 ,  C12N15/09 ,  C12Y114/11028

    Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.

    PIPECOLINIC ACID 4-HYDROXYLASE AND METHOD FOR PRODUCING 4-HYDROXY AMINO ACID USING SAME
    7.
    发明申请
    PIPECOLINIC ACID 4-HYDROXYLASE AND METHOD FOR PRODUCING 4-HYDROXY AMINO ACID USING SAME 有权
    邻苯二甲酸4-羟基酯及使用其生产4-羟基氨基酸的方法

    公开(公告)号：US20160348081A1

    公开(公告)日：2016-12-01

    申请号：US15115028

    申请日：2015-01-27

    Applicant: API CORPORATION

    Inventor： Makoto HIBI ,  Jun OGAWA ,  Ryoma MIYAKE ,  Hiroshi KAWABATA

    IPC: C12N9/02 ,  C12P17/10 ,  C12P17/12

    CPC classification number: C12N9/0071 ,  C12P13/04 ,  C12P17/10 ,  C12P17/12 ,  C12Y114/00 ,  C12Y114/11006

    Abstract: The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with α-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18, and having pipecolic acid 4-hydroxylase activity.

    PRODUCTION METHOD FOR L-CYCLIC AMINO ACIDS
    9.
    发明申请
    PRODUCTION METHOD FOR L-CYCLIC AMINO ACIDS 有权

    公开(公告)号：US20220275410A1

    公开(公告)日：2022-09-01

    申请号：US17606123

    申请日：2020-05-15

    Applicant: API CORPORATION

    Inventor： Masaharu MIZUTANI ,  Ryoma MIYAKE ,  Hiroshi KAWABATA

    IPC: C12P13/04 ,  C12N15/70 ,  C12P41/00 ,  C12N9/10

    Abstract: An object of the present invention is to provide a method of industrially producing a high-purity L-cyclic amino acid more inexpensively and with a high efficiency, from a cyclic amino acid having a double bond at the 1-position. The present invention provides a method in which an L-cyclic amino acid is produced by allowing a cyclic amino acid having a double bond at the 1-position to react with a specific enzyme having a catalytic ability to reduce a cyclic amino acid having a double bond at the 1-position to produce an L-cyclic amino acid.

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