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公开(公告)号：US11773380B1
公开(公告)日：2023-10-03
申请号：US17894854
申请日：2022-08-24
Applicant: Agilent Technologies, Inc.
Inventor： Michelle Cayouette , Jeffrey Fox , Connie Hansen , Holly Hogrefe , Weidong Wu
IPC: C12N9/12 , C12P19/34 , C12Q1/6869
CPC classification number: C12N9/1252 , C12P19/34 , C12Q1/6869 , C12Y207/07007
Abstract: Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3′-OH unblocked reversible terminators. The mutant polymerases may be used in a variety of applications, such as for polynucleotide sequencing, primer extension reactions, and template-independent enzymatic oligonucleotide synthesis.
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Patent Agency Ranking
公开(公告)号：US20240294886A1
公开(公告)日：2024-09-05
申请号：US18652554
申请日：2024-05-01
Applicant: Agilent Technologies, Inc.
Inventor： Michelle Cayouette , Jeffrey Fox , Connie Hansen , Holly Hogrefe , Weidong Wu
IPC: C12N9/12 , C12P19/34 , C12Q1/6869
CPC classification number: C12N9/1252 , C12P19/34 , C12Q1/6869 , C12Y207/07007
Abstract: Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3′—OH unblocked reversible terminators. The mutant polymerases may be used in a variety of applications, such as for polynucleotide sequencing, primer extension reactions, and template-independent enzymatic oligonucleotide synthesis.
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公开(公告)号：US20240018490A1
公开(公告)日：2024-01-18
申请号：US18464955
申请日：2023-09-11
Applicant: Agilent Technologies, Inc.
Inventor： Michelle Cayouette , Jeffrey Fox , Connie Hansen , Holly Hogrefe , Weidong Wu
IPC: C12N9/12 , C12Q1/6869 , C12P19/34
CPC classification number: C12N9/1252 , C12Y207/07007 , C12Q1/6869 , C12P19/34
Abstract: Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3′-OH unblocked reversible terminators. The mutant polymerases may be used in a variety of applications, such as for polynucleotide sequencing, primer extension reactions, and template-independent enzymatic oligonucleotide synthesis.
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4.发明授权公开(公告)号：US09758773B2
公开(公告)日：2017-09-12
申请号：US14568549
申请日：2014-12-12
Applicant: Agilent Technologies, Inc.
Inventor： Nancy Mckinney , Holly H. Hogrefe , Jeffrey Fox , Connie J. Hansen , Bahram Arezi
CPC classification number: C12N9/1252 , C12Q1/686 , C12Y207/07007
Abstract: The invention provides mutants of DNA polymerases having an enhanced resistance to inhibitors of DNA polymerase activity. The mutant polymerases are well suited for PCR amplification of targets in samples that contain inhibitors of wild-type polymerases.
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5.发明申请Thermostable Type-A DNA Polymerase Mutant with Increased Resistance to Inhibitors in Blood 有权耐热型A型DNA聚合酶突变体与血液中抑制剂抗性增加公开(公告)号：US20150232821A1
公开(公告)日：2015-08-20
申请号：US14568549
申请日：2014-12-12
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Nancy Mckinney , Holly H. Hogrefe , Jeffrey Fox , Connie J. Hansen , Bahram Arezi
CPC classification number: C12N9/1252 , C12Q1/686 , C12Y207/07007
Abstract: The invention provides mutants of DNA polymerases having an enhanced resistance to inhibitors of DNA polymerase activity. The mutant polymerases are well suited for PCR amplification of targets in samples that contain inhibitors of wild-type polymerases.
Abstract translation: 本发明提供对DNA聚合酶活性抑制剂具有增强抗性的DNA聚合酶突变体。 突变型聚合酶非常适用于含有野生型聚合酶抑制剂的样品中靶标的PCR扩增。
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公开(公告)号：US12006519B2
公开(公告)日：2024-06-11
申请号：US18464955
申请日：2023-09-11
Applicant: Agilent Technologies, Inc.
Inventor： Michelle Cayouette , Jeffrey Fox , Connie Hansen , Holly Hogrefe , Weidong Wu
IPC: C12N9/12 , C12P19/34 , C12Q1/6869
CPC classification number: C12N9/1252 , C12P19/34 , C12Q1/6869 , C12Y207/07007
Abstract: Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3′-OH unblocked reversible terminators. The mutant polymerases may be used in a variety of applications, such as for polynucleotide sequencing, primer extension reactions, and template-independent enzymatic oligonucleotide synthesis.
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