公开(公告)号：US20160376344A1

公开(公告)日：2016-12-29

申请号：US15163561

申请日：2016-05-24

Applicant: Amunix Operating Inc.

Inventor： Volker SCHELLENBERGER ,  Pei-Yun CHANG ,  Fatbardha VARFAJ ,  John KULMAN ,  Tongyao LIU ,  Garabet G. TOBY ,  Haiyan JIANG ,  Robert PETERS ,  Deping WANG ,  Baisong MEI ,  Joshua SILVERMAN ,  Chia-Wei WANG ,  Benjamin SPINK ,  Nathan GEETHING

IPC: C07K14/755 ,  C07K14/00

CPC classification number: C07K14/755 ,  A61K38/00 ,  C07K14/001 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/31 ,  C07K2319/41 ,  C07K2319/50 ,  C07K2319/95

Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.